Deciphering the role of alternative splicing in neoplastic diseases for immune-oncological therapiesImmunology Review Published on 2024-04-262024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] alternative splicing Antibody therapy CTLA-4 HLA-G Immune checkpoints PD-1 PD-L1 [DOI] 10.3389/fimmu.2024.1386993 PMC 바로가기 [Article Type] Immunology Review
Effect of SARS-CoV-2 infection in pregnancy on CD147, ACE2 and HLA-G expressionArticle Published on 2023-01-052024-09-05 Journal: Placenta [Category] update2024, [키워드] ACE-2, Angiotensin Converting Enzyme 2 ACE2 CD147 COVID-19, Coronavirus disease 2019 HLA-G HLA, human leukocyte antigen ILT, Ig-like transcript KIR, Killer-cell immunoglobulin-like receptor NK, natural killer Placental infection SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 TMPRRS2, Transmembrane serine protease 2 [DOI] 10.1016/j.placenta.2023.01.004 PMC 바로가기 [Article Type] Article
Induction of pulmonary HLA-G expression by SARS-CoV-2 infectionArticle Published on 2022-11-052022-11-15 Journal: Cellular and Molecular Life Sciences [Category] SARS, 치료기술, 치료제, [키워드] accompanied Antigen Autopsy biopsies CD8 Cell changes in correlated distribution epithelial cell Evidence expressed expression expression level Frequency heart muscle HLA-G Hyperactivation Immune cell Immune cell infiltration immune cells Immune escape immune response induction information kidney leukocyte lung lung alveolar lung epithelia lung epithelial cell lung tissue Macrophage marker microRNA miRNA miRNA expression modulating organs other organ patients protein expression SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2- SARS-CoV-2-infected patient specimen Spike protein surgical T cell responses T cells therapeutic target tissue tissues Treatment Tumor virus-infected cells while [DOI] 10.1007/s00018-022-04592-9 PMC 바로가기
HLA-G 14-bp insertion/deletion polymorphism and risk of coronavirus disease 2019 (COVID-19) among Iraqi patients이라크 환자의 HLA-G 14bp 삽입/삭제 다형성 및 코로나바이러스 질병 2019(COVID-19)의 위험Article Published on 2022-06-012022-09-11 Journal: Human immunology [Category] 변종, [키워드] 14-bp insertion/deletion polymorphism 3′UTR 95% confidence interval allele Antigen case-control study conducted Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical disease Del disease severity Frequency Gender Genotype genotypes higher risk HLA-G Human human leukocyte antigen insertion insertion/deletion leukocyte median no significant difference no significant differences Odds ratio Patient patients with COVID-19 patients with moderate polymorphism Probability Result risk risk of COVID-19 SARS-CoV-2 serum significantly significantly higher stratified suggested susceptibility up-regulated with COVID-19 [DOI] 10.1016/j.humimm.2022.03.005 PMC 바로가기 [Article Type] Article
The Different Immune Responses by Age Are due to the Ability of the Fetal Immune System to Secrete Primal Immunoglobulins Responding to Unexperienced Antigens연령에 따른 다른 면역 반응은 미숙한 항원에 반응하는 원시 면역글로불린을 분비하는 태아 면역 체계의 능력 때문입니다Research Paper Published on 2022-01-012022-09-10 Journal: International Journal of Biological Sciences [Category] SARS, 유전자 메커니즘, [키워드] Ability acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity age aging analyzed antibody Antigen Antiviral antiviral proteins Birth cells complement component components condition conditions coronavirus Coronavirus 2019 COVID-19 Critical Culture decrease demonstrated early pregnancy environmental factor EVs extracellular vesicle Extracellular vesicles Factor fetal fetal immune system form FSC HLA-G human leukocyte antigen Hypothesis IgG3 IgM immune reaction immune system immune systems immune tolerance Immunoglobulin immunoglobulin M immunoglobulins independent Infection Infectious disease Infectious diseases leukocyte mechanism mortality rate mutations NAbs natural antibody Pregnancy produced Protein Proteins respiratory Responding response responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus stem cell stem cells susceptible System [DOI] 10.7150/ijbs.67203 PMC 바로가기 [Article Type] Research Paper
Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling PathwaysCOVID-19에서 차별적으로 발현되는 유전자의 식별 및 신호 전달 경로의 통합 생물정보학 분석Research Article Published on 2021-12-242022-09-10 Journal: Genetics Research [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis analyzed annotation bioinformatics cause CD69 cellular response chromosome complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cutoff CXCR4 cytokine cytokine production DAVID DEGs Diabetic diabetic complications Diagnosis Differentially expressed genes downregulated enrichment FN1 FoxO FOXP3 gene expression profile Gene ontology GO terms group GSEA help HLA-G hub genes identification IL-17 immune response involved ISG15 KEGG Kyoto leukocyte lung tissue mechanism MMP9 myeloid leukocyte necrotic necrotic cell death nuclear other disease pathway Pathways Pneumonia positive potential mechanisms potential molecular PPI protein-protein interaction RAGE Regulation Research screened selected signaling pathway target Treatment type I interferon upregulated Visualization [DOI] 10.1155/2021/2728757 PMC 바로가기 [Article Type] Research Article
Perspective of HLA-G Induced Immunosuppression in SARS-CoV-2 InfectionImmunology Published on 2021-12-062022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome antibody production antiviral immune response Apoptosis B cell caused CD8 Cell Cellular immune response coronavirus COVID-19 COVID-19 disease dendritic cell disease disease severity expression HLA-G Host Human identify immune attack Immune cell immune inhibitory Immune receptor immune responses Immune suppression immunopathological induce induced inhibit inhibitory receptor Interaction KIR knowledge leukocyte Ligand macrophages maturation natural killer NK cell outcomes patients with COVID-19 progression provoke public health receptors regulatory cell SARS-CoV-2 SARS-COV-2 infection T cell the disease transcript upregulated viral clearance viral infections [DOI] 10.3389/fimmu.2021.788769 PMC 바로가기 [Article Type] Immunology
B Cells Control Mucosal-Associated Invariant T Cell Responses to Salmonella enterica Serovar Typhi Infection Through the CD85j HLA-G ReceptorB 세포는 CD85j HLA-G 수용체를 통해 Salmonella enterica Serovar Typhi 감염에 대한 점막 관련 불변 T 세포 반응을 조절한다.Original Research Published on 2021-10-012024-07-29 Journal: Frontiers in immunology [Category] 살모넬라증, [키워드] HLA-G Human intestine MAIT cells S. Typhi [DOI] 10.3389/fimmu.2021.728685 PMC 바로가기 [Article Type] Original Research
Increased sHLA-G Is Associated with Improved COVID-19 Outcome and Reduced Neutrophil Adhesion증가 된 SHLA-G는 개선 된 COVID-19 결과 및 호중구 접착 감소와 관련이 있습니다.Article Published on 2021-09-172022-08-31 Journal: Viruses [Category] SARS, 바이오마커, [키워드] activated Activation adhesion Admission Analysis Biomarker Blood CD160 changes in clinical condition clinical evolution Clinical improvement control patients controls COVID-19 COVID-19 patient COVID-19 patients E-selectin ELISA assay endothelial Endothelial cell endothelial cells Endothelium evaluated expression FGF2 HLA HLA-G hospitalized COVID-19 patient hospitalized COVID-19 patients human leukocyte antigen ICAM-1 Improved in vitro Increased infective Inflammatory Interaction inverse correlation involved leukocyte molecules neutrophil plasma Plasma levels plasma samples quantified Respiratory failure responses selectin serum significantly higher [DOI] 10.3390/v13091855 PMC 바로가기 [Article Type] Article
Puzzling out the COVID-19: Therapy targeting HLA-G and HLA-ECOVID-19에 대한 수수께끼: HLA-G 및 HLA-E를 표적으로 하는 치료Review Published on 2020-12-012022-09-11 Journal: Human immunology [Category] SARS, 치료제, [키워드] antibody approved argument classical Combination complex core COVID-19 COVID-19 complications COVID-19 patient critical cases Dosing FDA form function healthcare Healthcare system Healthcare systems help HLA class I HLA class I molecules HLA-E HLA-G Immune cell immune cells immune tolerance immunological mechanism NKG2A plasma receptor respiratory respiratory complication Respiratory complications SARS-CoV2 SARS-CoV2 infection therapy treat virus [DOI] 10.1016/j.humimm.2020.10.001 PMC 바로가기 [Article Type] Review