Heartland Virus Disease—An Underreported Emerging InfectionReview Published on 2024-01-292024-09-05 Journal: Microorganisms [Category] update2024, [키워드] Amblyomma americanum bandavirus Favipiravir Heartland Heartland virus hemophagocytic lymphohistiocytosis HLH HRTV RNA virus tanshinone tickborne disease [DOI] 10.3390/microorganisms12020286 PMC 바로가기 [Article Type] Review
Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis심각한 VZV 감염 및 혈구탐식 림프조직구증을 앓고 있는 환자에서 E3 유비퀴틴 리가제 AMFR의 변이에 의한 STING 활성화 손상Article Published on 2024-01-262024-08-16 Journal: Journal of Clinical Immunology [Category] 대상포진, [키워드] AMFR HLH interferon ISG STING ubiquitin ligase VZV.
An Unusual Case of Hemophagocytic Lymphohistiocytosis Associated with Mycobacterium chimaera or Large-Cell Neuroendocrine CarcinomaCase Report Published on 2023-03-212024-09-05 Journal: Current Oncology [Category] update2024, [키워드] COVID-19 hemophagocytic lymphohistiocytosis HLH Infection M. chimera malignancy Mycobacterium chimaera Neuroendocrine Cell Carcinoma [DOI] 10.3390/curroncol30030268 PMC 바로가기 [Article Type] Case Report
Changing Disease Course of Crimean-Congo Hemorrhagic Fever in Children, TurkeySynopsis Published on 2023-02-012024-09-05 Journal: Emerging Infectious Diseases [Category] update2024, [키워드] CCHF chemokines children Crimean-Congo hemorrhagic fever Cytokines febrile infections hemophagocytic lymphohistiocytosis HLH MIS-C multisystem inflammatory syndrome in children Turkey viral hemorrhagic fevers viruses [DOI] 10.3201/eid2902.220976 PMC 바로가기 [Article Type] Synopsis
Histiocytosis-lymphadenopathy plus syndrome revealed by repeated secondary hemophagocytic lymphohistiocytosisArticle Published on 2022-05-012023-07-09 Journal: Pediatric allergy and immunology : official public [Category] COVID19(2023년), [키워드] H syndrome HLH Intravenous immunoglobulin Multisystem inflammatory syndrome post-viral immune dysregulation. SARS-CoV2 [DOI] 10.1111/pai.13787
Up-regulated serum levels of soluble CD25 and soluble CD163 in pediatric patients with SARS-CoV-2SARS-CoV-2 소아 환자에서 가용성 CD25 및 가용성 CD163의 상향 조절된 혈청 수준Original Article Published on 2022-03-022022-09-11 Journal: European journal of pediatrics [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] age antagonist antagonists CD163 children Control COVID-19 cytokine Cytokine storm diagnostic biomarker Diagnostic biomarkers disease severity ELISA healthy control help hemophagocytic lymphohistiocytosis HLH host response Inflammatory initial Level marker MIS-C monitoring outcome Patient patients with COVID-19 patients with SARS-CoV-2 Pediatric patient presenting pro-inflammatory receptor SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 patients sCD163 sCD25 serum Serum level severity significant decrease significantly higher soluble CD25 syndrome the disease the healthy therapeutic Treatment up-regulated were measured [DOI] 10.1007/s00431-022-04398-8 PMC 바로가기 [Article Type] Original Article
Hemophagocytic lymphohistiocytosis after SARS-CoV-2 vaccinationCase Reports Published on 2022-02-262022-10-29 Journal: Infection [Category] COVID-19, COVID19(2023년), MERS, SARS, 진단, [키워드] addition adverse effect Anakinra approval combination treatment coronavirus disease Corticosteroid COVID-19 COVID-19 vaccine Dexamethasone female ferritin Frequency full recovery HLH Hyperferritinemia hyperinflammation immunization Intravenous immunoglobulin Kineret Lymphadenopathy macrophage activation syndrome majority mechanism mRNA pandemic Patient patients died performed Probability receptor reported Result SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine treated Treatment Trial vaccination Vaccine Viral vector vaccine [DOI] 10.1007/s15010-022-01786-y PMC 바로가기 [Article Type] Case Reports
Is COVID-19-associated cytokine storm distinct from non-COVID-19 secondary hemophagocytic lymphohistiocytosis?COVID-19 관련 사이토카인 폭풍은 비-COVID-19 이차성 혈구포식성 림프조직구증과 구별되는가?Review Published on 2022-02-012022-09-12 Journal: Experimental Biology and Medicine [Category] MERS, 진단, [키워드] acute respiratory distress adaptive ARDS characterized circulating cytokine Clinical diagnosis COVID-19 criteria cytokine Cytokine storm Cytokines Diagnosis elevated hemophagocytic lymphohistiocytosis HLH Hyperactivation immune cells immunobiology immunology/microbiology/virology Inflammation Inflammatory Non-COVID-19 patients Pneumonia syndrome Treatment [DOI] 10.1177/15353702211068840 PMC 바로가기 [Article Type] Review
A Rare STXBP2 Mutation in Severe COVID-19 and Secondary Cytokine Storm SyndromeArticle Published on 2022-01-202022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] accompanied Activation approach Blood caused CD107a CD8 T cell Cell clinical feature Coronavirus disease 2019 COVID-19 cytokine levels Cytokine storm Cytokine storm syndrome cytolysis cytotoxicity death degranulation disease dominant-negative elevated erythroleukemia etiologies Ex vivo expression feature gene mutations genetic defect genetic evaluation genetic mutations genetics hemophagocytic lymphohistiocytosis heterozygous HLH homozygous hyperinflammation hypomorphic Hypothesis immune response immune system implicated implication in vitro infancy Laboratory lentiviral macrophage activation syndrome Missense mutation monoallelic mutant Mutation natural killer natural killer cell NK cell NK cell function resulting secondary Severe case severe COVID-19 sHLH significantly stimulated storm STXBP2 syndrome system failure target cell transduced triggered viral infection were measured while wild-type [DOI] 10.3390/life12020149 PMC 바로가기 [Article Type] Article
COVID-19 and SepsisArticle Published on 2021-12-172022-10-29 Journal: Turkish Journal of Medical Sciences [Category] COVID-19, SARS, [키워드] acute phase reactant acute respiratory distress addition affecting alterations ARDS assist association Autopsy Bacterial sepsis Blood cause caused Cell changes chemokine Clinical deterioration coagulation tests component consolidation contributing to Course COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient COVID-19 sepsis CRP Cytokine storm D-dimer demonstrated Diffuse alveolar damage direct viral infection dominant dysregulated immune response endothelial injury explained Faeces feature ferritin Gallbladder hematological hemorrhage histopathological HLH hospitalized patient Hyperactivation hypercoagulability hypercoagulable hyperinflammation immune immune response IMPROVE indicated infiltration inflammatory cell intrinsic Laboratory laboratory parameter limit liver liver function tests lung tissue Lungs macrophages manifestation modulate multiorgan failure multiple organ organ systems organs outcome overlapping pandemic Pathogenesis pathogenesis of COVID-19 Pathogens Result SARS-CoV-2 Sepsis serum cytokine Severe case severe COVID-19 severe COVID-19 disease Severe COVID-19 Infection severe COVID-19 patients similarity syndrome systemic inflammation tissue Treatment unique Urine Vascular viral disease viral particle virus while [DOI] 10.3906/sag-2108-239 PMC 바로가기 [Article Type] Article