Understanding COVID-19 Pathogenesis: A Drug-Repurposing Effort to Disrupt Nsp-1 Binding to Export Machinery Receptor ComplexArticle Published on 2021-12-172022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Antiviral beta coronavirus binding complex conformation COVID-19 COVID-19 infection crystal structure docking docking score drug drug antagonists drugs targeting export FDA-approved drug form Ganirelix Gene Expression GNRHR gonadotrophs hormone receptor Host include induce interact interfere knowledge Messenger RNA mRNA mRNA export adaptor nonstructural protein 1 nsp1 nuclear nuclear export NXF1 NXT1 offer Pituitary Protein recent receptor complex Repurposed drug RNA SARS-CoV-2 virus secretion shown Structural analysis structural docking structural modeling Transport understanding unlikely virulence [DOI] 10.3390/pathogens10121634 PMC 바로가기 [Article Type] Article
Effectiveness of a Short Duration of Neoadjuvant Endocrine Therapy in Patients with HR+ Breast Cancer-An NCDB Analysis (2004-2016)HR+ 유방암 환자에서 단기간 신보조제 내분비 요법의 효과 - NCDB 분석(2004-2016)Article Published on 2021-12-012022-09-11 Journal: Annals of Surgical Oncology [Category] SARS, 바이오마커, [키워드] analysis of variance ANOVA Breast Breast cancer category Characteristics clinical Clinical characteristics Clinical outcome Cohort Comorbidity Complete coronavirus disease Coronavirus disease 2019 COVID-19 determine diagnosed Duration Effect Endocrine Endocrine Therapy evaluate evaluated Factor female patient Female patients Future Government histology hormone receptor Interaction invasive lobular Logistic regression moderate multivariable logistic regression NET objective Older age organization pandemic pathologic Patient patients positive response rate study cohort therapy was used [DOI] 10.1245/s10434-021-10287-5 PMC 바로가기 [Article Type] Article
Roles of steroid receptors in the lung and COVID-19Endocrinology Published on 2021-11-262022-10-31 Journal: Essays in Biochemistry [Category] COVID-19, SARS, [키워드] ACE2 androgen angiotensin-converting enzyme 2 caused clinical trial coronavirus COVID-19 COVID-19 symptom disease Effect Estrogens expression facilitate glucocorticoid hormone receptor host cell immune system Infection knowledge Ligand lung lung epithelia Lungs Mortality Nuclear receptors progesterone Protein provide receptor respiratory role SARS-CoV-2 Steroids TMPRSS2 transmembrane serine protease treat [DOI] 10.1042/EBC20210005 PMC 바로가기 [Article Type] Endocrinology
Deep learning‐based survival analysis for brain metastasis patients with the national cancer databaseRadiation Oncology Physics Published on 2020-08-132022-10-30 Journal: Journal of Applied Clinical Medical Physics [Category] Coronavirus, MERS, SARS, [키워드] age Analysis assessment Brain brain metastasis breast cancer patient Cancer classical clinical setting clinically Concordance covariate Cox proportional hazard CPU database deep deep learning hormone receptor information machine learning Metastasis National Patient patient survival physician Predictive previous study Prognosis prognostic indicator provided random Result risk RPA shown statistically significant difference stereotactic radiosurgery survival Test the mean treatment regimen was used were used [DOI] 10.1002/acm2.12995 PMC 바로가기 [Article Type] Radiation Oncology Physics
Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulationOriginal Article Published on 2020-06-192022-10-28 Journal: Aging Cell [Category] COVID-19, SARS, [키워드] ACE2 ACE2 binding ACE2 expression acute respiratory syndrome age all ethnic groups Asian binding site cardiovascular diseases contributing to coronavirus COVID‐19 COVID‐19 Data analysis decrease diabetic patient East Asians enzyme eQTLs Ethnic groups expression expression levels fatality female females Gene Expression Genes hormone receptor host cell receptor Human individual variation individuals Inflammatory cytokine loci majority male mice molecular negative correlation Older pathogen pathway Patient population level Quantitative receptor ACE2 reduced regions Regulation Regulatory SARS‐CoV‐2 SARS‐COV2 Sex sex hormone shown significant decrease significantly higher T2D tissue transcription factor Treatment treatment strategy upregulated upregulation viral infection virus infection [DOI] 10.1111/acel.13168 PMC 바로가기 [Article Type] Original Article
Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice감수 분열 게이트 키퍼 STRA8은 생쥐의 정자 형성 동안 Nr1d1 발현을 억제하여자가 포식을 억제합니다Research Article Published on 2019-05-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition autophagy bind Cell cell cycles cells cellular chromosomal cohesion Critical demonstrated DNA double strand double strand break DSBs ectopic expression Effect expression Fertility function Genes Genetic genomic germ cells haploid gamete homolog hormone receptor inhibit male maturation meiosis meiotic mice mitotic molecular Nr1d1 nuclear organelle promoter Protein Recombination required retinoic acid sexual reproduction spermatogenesis STRA8 suppresse suppressor synapsis target gene Target genes Transcription transcriptional transition turn Ulk1 upregulated upregulation Vertebrate vertebrates [DOI] 10.1371/journal.pgen.1008084 PMC 바로가기 [Article Type] Research Article
The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C . elegans핵 호르몬 수용체 NHR-86은 C에서 항병원체 반응을 조절한다. 엘레강스Research Article Published on 2019-01-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation adaptive Analysis Author bacterial pathogen baseline bind biological function canonical characterized chromatin chromatin immunoprecipitation Control determine Drosophila effector elegan elegans exogenous ligands experiments family function Genetic genetic screen Genome homolog hormone receptor hormone receptors host response Human immune immune activation immunostimulatory induce Infection innate immune activation majority MAPK modulate nuclear pathogen pathway PMK-1 positioned promoter promoters Protective Protein provide Pseudomonas aeruginosa Recognition Regulation required response small molecule target Transcription transcription factor transcription factors transcriptional transcriptional regulator transcriptional response Transcriptome [DOI] 10.1371/journal.pgen.1007935 PMC 바로가기 [Article Type] Research Article
Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor초파리의 기능성 남성 액세서리 땀샘과 생식력에는 새로운 엑디손 수용체가 필요합니다Research Article Published on 2017-05-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Nuclear Receptors) analyzed Behavior Biodiversity carried cause cell death cells Critical Depletion dominant negative downstream Drosophila Drosophila melanogaster dying cells Ecdysone examined females Fertility forms Health hormone hormone receptor hormone receptors include independent insect Insects isoform male male fertility male reproductive system males management mechanism of action molecular Nuclear receptors pest control Physiology Protein protein synthesis Proteins receptor receptors regulated Regulation reproduction reproductive reproductive system secretory tissue Seminal fluid sterility tissue transcription factor transcription factors transfer [DOI] 10.1371/journal.pgen.1006788 PMC 바로가기 [Article Type] Research Article