MicrobiomeCensus estimates human population sizes from wastewater samples based on inter-individual variability in gut microbiomesArticle Published on 2022-09-232022-11-16 Journal: PLoS Computational Biology [Category] 변종, [키워드] Algorithm approach comparison COVID-19 pandemic data-driven deviation distribution ecological estimate exhibited fraction Gut Health status Host human disease inter-individual Interpretation likelihood mathematical means metagenome Microbiome New populations Prevalence provide provided public health real time Research Sample size shown Variability variant [DOI] 10.1371/journal.pcbi.1010472 PMC 바로가기
Stem cell-based therapy for human diseases Reviews Published on 2022-08-062022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 임상, 치료제, [키워드] acute respiratory distress adipose Bone marrow Brain burns candidate cardiovascular conditions Cell cell type cellular phenotype clinical setting clinical trial contribute defined disease Diseases disorder disorders downstream human disease human diseases Hypothesis in vitro ISCT lineages mechanism MSC MSCs Neurological disorders Patient pluripotent stem cell progenitor cell provide pulmonary disease recent regenerative reproductive Research Society Spinal cord injury STEM stem cell Support syndrome targeted therapy therapy tissue translational treated Treatment UC-MSC umbilical [DOI] 10.1038/s41392-022-01134-4 [Article Type] Reviews
Identification of genomic determinants contributing to cytokine release in immunotherapies and human diseases면역 요법 및 인간 질병에서 사이토카인 방출에 기여하는 게놈 결정인자의 식별Article Published on 2022-07-282022-09-11 Journal: Journal of Translational Medicine [Category] Coronavirus, 유전자 메커니즘, [키워드] abrogate Analysis Autoimmune diseases CAR CAR T-cell therapy CD22 cells cellular Cohort cohorts collected contribute contributing to CRS cytokine release Cytokine release syndrome dataset determinant develop driving drugs targeting expression Frequency genomic Glycolysis human disease identification immune system Immunotherapy IMPROVE in vivo Infection Influenza influenza infection influenza infections lupus erythematosus management mRNA not increased occur outcomes pathway Patient patients with influenza PFKFB4 PFKFB4. platform Prevent reaction reduce RNA extraction severity SLE syndrome systemic lupus erythematosus T-cell T-cells targeted therapy therapy tissues Treatment Tumor upregulated was used were used while with COVID-19 [DOI] 10.1186/s12967-022-03531-3 PMC 바로가기 [Article Type] Article
Targeting TFH cells in human diseases and vaccination: rationale and practice Reviews Published on 2022-07-112022-10-05 Journal: Nature Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] allergens antibody antibody affinity Antigen approach Autoantigens B cell B cells boost CD4+ T cell Cell cytokine disease disease pathogenesis Efficacy facilitate human disease Humoral immunity Infection knowledge lymphomagenesis maturation mechanisms memory pathogen clearance pathogenic protective antibody response receptor regulate Regulation reservoirs response Support survival T cell targeting TCR therapy Vaccine [DOI] 10.1038/s41590-022-01253-8 [Article Type] Reviews
Cell and Animal Models for SARS-CoV-2 ResearchSARS-CoV-2 연구를 위한 세포 및 동물 모델Review Published on 2022-07-092022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal animal model animal models antiviral drug antiviral drugs approach Cell cell model Compound concerning coronavirus COVID-19 develop drug effective Effectiveness Evolution experimental model experimental models Health human disease information Model pandemic pathophysiology SARS-CoV-2 severe acute respiratory syndrome Coronavirus therapeutic targets Vaccine virus [DOI] 10.3390/v14071507 PMC 바로가기 [Article Type] Review
Hamster models of COVID-19 pneumonia reviewed: How human can they be?COVID-19 폐렴의 햄스터 모델 검토: 어떻게 인간이 될 수 있습니까?Review Published on 2022-07-012022-09-11 Journal: Veterinary pathology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age alveolar damage animal model characteristic clinically Coagulopathy condition consequence coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 diagnostic Diffuse alveolar damage examined facilitate feature hamster hamsters Histopathology Human human disease humans immune function immune functions Infection Inference Inflammation information limit manifestation Mesocricetus mice moderate molecular outcome pandemic pathology pathway Patient Phodopus Pneumonia Preclinical research Research respiratory respiratory tract review rodents SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarity Still susceptible susceptible patient the disease therapy Vaccines variants of concern Vascular virus [DOI] 10.1177/03009858211057197 PMC 바로가기 [Article Type] Review
Emerging trends of edible vaccine therapy for combating human diseases especially COVID-19: Pros, cons, and future challenges인간 질병, 특히 COVID-19 퇴치를 위한 식용 백신 요법의 새로운 경향: 찬반 양론 및 미래 과제Review Published on 2022-07-012022-09-11 Journal: Phytotherapy research : PTR [Category] 유전자 메커니즘, [키워드] administration clinical trials combating conventional vaccine conventional vaccines COVID-19 develop drugs edible vaccine effective effort Evidence human disease human diseases immunomodulatory mechanism mechanism of action minimum monoclonal antibodies oral administration oral vaccines Perspective plant plant-extracts plants PROTECT Proteins researcher SARS-CoV-2 Side effect Side effects stages therapy transgenic transgenic plant. Vaccine vaccine candidate Vaccines [DOI] 10.1002/ptr.7475 PMC 바로가기 [Article Type] Review
Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary InflammationZ-RNA 감지, 인플루엔자 바이러스 유발 세포 사멸 및 폐 염증에서 ZBP1의 새로운 역할Review Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Apoptosis Cell cell death coronavirus Critical cytopathic death Defense epithelial epithelial cell functional highly pathogenic Host host cell host defense human disease IAV immune sensing immunopathology in vivo Infection Inflammasome Inflammation Inflammatory response Inflammatory responses Influenza influenza A influenza A virus influenza infections influenza viruses Innate Innate immunity Lung infection mechanism necroptosis nucleic acid outbreak Pandemics pathogenic pathogenicity proinflammatory Proinflammatory response promote pulmonary pyroptosis Respiratory illness Respiratory tract infections responses RIPK3 RNA RNA virus role SARS-CoV-2 Signaling triggering understanding viral infections viral strain virus Z-RNA ZBP1 zoonotic transmission [DOI] 10.1128/mbio.00401-22 PMC 바로가기 [Article Type] Review
Expediting knowledge acquisition by a web framework for Knowledge Graph Exploration and Visualization (KGEV): case studies on COVID-19 and Human Phenotype OntologyKGEV(Knowledge Graph Exploration and Visualization)용 웹 프레임워크를 통한 신속한 지식 습득: COVID-19 및 인간 표현형 온톨로지에 대한 사례 연구Article Published on 2022-06-022022-09-12 Journal: BMC Medical Informatics and Decision Making [Category] MERS, 진단, [키워드] acquisition computational method computational tool COVID-19 COVID-19 pandemic Data visualization database dataset demonstrated downstream eight emerging disease exploration facilitate filtration FIVE generate heterogenous Human human disease hypotheses information Information extraction knowledge Knowledge discovery Knowledge graph Knowledge graph. lack Metadata phenotypic question reliability Research shortest path Support utility Visualization [DOI] 10.1186/s12911-022-01848-z PMC 바로가기 [Article Type] Article
Tuaimenal A, a Meroterpene from the Irish Deep-Sea Soft Coral Duva florida, Displays Inhibition of the SARS-CoV-2 3CLpro Enzyme아일랜드 심해 연성 산호 Duva florida의 메로테르펜인 Tuaimenal A, SARS-CoV-2 3CLpro 효소 억제 표시Review Published on 2022-05-272022-09-11 Journal: Journal of natural products [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro Bioactivity biochemical assay carbon Cold collected Continental margin Coral display docking experiment exploration human disease in silico inhibit inhibition invertebrate margin Meroterpene metabolome protease representing SARS-CoV-2 Soft the SARS-CoV-2 was determined water [DOI] 10.1021/acs.jnatprod.2c00054 PMC 바로가기 [Article Type] Review