Angiotensin-converting enzyme 1 and voltage-gated potassium channel-interacting protein 4 gene polymorphisms in COVID-19 patients from east of IranArticle Published on 2022-11-012022-11-15 Journal: Clinica chimica acta; international journal of cli [Category] 진단, [키워드] ACE1 acute respiratory syndrome affecting Angiotensin-converting enzyme Angiotensin-converting enzyme 1 Care case-control study caused coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 susceptibility death disease enzyme Ethnic groups Factor Frequency Genetic Genotype genotyped Health healthy controls I/D polymorphism Infection Iran KCNIP4 material outcome pandemic pathogen PCR polymorphism Polymorphisms populations Potassium Prognostic factor Protein Region Research Respiratory disease severe acute respiratory syndrome coronavirus 2 severity statistically significant supported survival Variation Voltage-gated potassium (Kv) channel-interacting protein 4. [DOI] 10.1016/j.cca.2022.09.006 PMC 바로가기
Are angiotensin converting enzyme (ACE1/ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A single-center cohort study안지오텐신 전환 효소(ACE1/ACE2) 유전자 변이가 COVID-19 폐렴의 임상 중증도와 관련이 있습니까? 단일 센터 코호트 연구Article Published on 2022-02-012022-09-11 Journal: Anatolian journal of cardiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] abnormality ACE ACE gene ACE1 ACE1 gene ACE1/ACE2 ACE2 ACE2 gene Admission age allele Analysis angiotensin angiotensin converting enzyme automated Bioinformatics analysis Clinical characteristics Clinical severity Cohort cohort study coronavirus disease Coronavirus disease 2019 COVID-19 determine disease severity DNA domain DSP enzyme exon 1 frequencies Frequency functional Genetic Genomic DNA Genotype group I/D polymorphism ICU independent predictor independent predictors intensive care intensive care unit investigated knowledge no effect non-ICU Older age other variant pandemic Patient patients hospitalized Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia polymorphism Polymorphisms purified radiologic recent Sanger sequencing Science Sequencing analysis severe disease single-center statistical analysis Statistical Package variant was performed was used [DOI] 10.5152/AnatolJCardiol.2021.502 PMC 바로가기 [Article Type] Article
Assessment of ACE1 variants and ACE1/ACE2 expression in COVID-19 patientsCOVID-19 환자에서 ACE1 변이체 및 ACE1/ACE2 발현 평가Article Published on 2022-02-012022-09-11 Journal: Vascular pharmacology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE ACE1 ACE1 gene ACE1/ACE2 ACE2 ACE2 expression Affect allele angiotensinogen assessment association carrier carriers circulation Complication Control controls COVID-19 COVID-19 patient distribution ether examined expression expression level expression levels Expression. Frequency Genotype genotyped genotypes groups healthy controls I/D polymorphism ICU patient ICU Patients mRNA level non-ICU non-ICU patient non-ICU patients not different not significantly different p value Patient patients polymorphism Renin risk of COVID-19 significantly higher study groups total population transcripts two group two groups variant while [DOI] 10.1016/j.vph.2021.106934 PMC 바로가기 [Article Type] Article
The Role of Angiotensin Converting Enzyme 1 Insertion/Deletion Genetic Polymorphism in the Risk and Severity of COVID-19 InfectionMedicine Published on 2021-12-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE1 ACE1 ACE1 gene addition agarose gel age allele Analysis angiotensin association Blood carrier center clinical collected common allele Comorbidity Control COVID COVID-19 COVID-19 disease COVID-19 infection COVID-19 virus described determine disease disease severity DNA driving explain Factor Frequency Gender genetic differences Genetic polymorphism genetics Genotype genotyping greater Hospitalization I/D I/D polymorphism incidence increase in increased risk individual Infection Isolation management medical records outcome PCR PCR testing performed peripheral polymorphism positive predict Prognosis questionnaire recruited risk risk factor role severe symptom severity severity of COVID-19 Sex significantly higher significantly increased study population subjects susceptibility Symptom the disease university withdrawn [DOI] 10.3389/fmed.2021.798571 PMC 바로가기 [Article Type] Medicine
Strong Association of Angiotensin Converting Enzyme-2 Gene Insertion/Deletion Polymorphism with Susceptibility to SARS-CoV-2, Hypertension, Coronary Artery Disease and COVID-19 Disease MortalityArticle Published on 2021-10-272022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] 95% CI ACE ACE gene ACE1-angiotensin-converting enzyme 1 ACE2 ACE2-angiotensin-converting enzyme 2 addition advanced age age allele allelic amplification Analysis angiotensin angiotensin-converting enzyme 2 Artery association bind Control controls Coronary Coronary artery disease correlation COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients COVID-19 severity diabete distribution facilitate Frequency functional Gender gene polymorphism Genotype genotyping group Health healthy control host cell hypertension I/D I/D polymorphism indicated Infection insertion/deletion International ischemic heart disease Mortality Mutation outbreak P -value Pathogenesis pathogenesis of COVID-19 PCR protective factor public health receptor reported Result rs4240157 SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity significant difference Spike protein Strong susceptibility to SARS-CoV-2 susceptible T2D targeted intervention virus entry with COVID-19 [DOI] 10.3390/jpm11111098 PMC 바로가기 [Article Type] Article
Angiotensin–Converting Enzyme (ACE) 1 Gene Polymorphism and Phenotypic Expression of COVID-19 Symptoms안지오텐신-전환 효소(ACE) 1 유전자 다형성 및 COVID-19 증상의 표현형 발현Review Published on 2021-10-012022-09-10 Journal: Genes [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] ACE1 I/D polymorphism ACE ACE1 ACE1 gene ACE2 Affect aldosterone Alu angiotensin appear article Asia association biochemical candidate Candidates Clinical outcome Comorbidities component concert conducted country COVID-19 COVID-19 symptoms diagnosis of SARS-CoV-2 East evaluate Evidence explain expression Frequency Genes Genotype group homolog Hypothesis I/D polymorphism Infection infections influence insertion Interaction involved mechanisms Medline database Mortality MOST numbers of patient opposite organ Pathogenesis pathogenesis of COVID-19 pathophysiology phenotypic Phenotypic Expression polymorphism Polymorphisms pulmonary disease RAAS reported Research risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections searched selected severity subgroups subgroups of patients Support Treatment West [DOI] 10.3390/genes12101572 PMC 바로가기 [Article Type] Review
Polymorphisms of ACE (I/D) and ACE2 receptor gene (Rs2106809, Rs2285666) are not related to the clinical course of COVID-19: A case studyACE(I/D)와 ACE2 수용체 유전자(Rs2106809, Rs2285666)의 다형성은 코로나19의 임상 경과와 관련이 없음: 사례 연구Article Published on 2021-10-012022-09-11 Journal: Journal of medical virology [Category] SARS, 유전자 메커니즘, [키워드] ACE ACE gene ACE2 ACE2 gene ACE2 receptor gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect allele frequency angiotensin Angiotensin-converting enzyme caused Chain Reaction Clinical course Clinical symptoms coagulation indicators coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathogenesis COVID-19 patient COVID-19 severity Critical Cytokines distribution enzyme Epigenetic Evidence expression Genotype groups human ACE2 receptor I/D I/D polymorphism Infection Infectious disease influence insertion/deletion mechanism Mild moderate outcome pandemic Pathogenesis PCR polymerase chain polymerase chain reaction polymorphism Polymorphisms pro-inflammatory cytokine pro-inflammatory cytokines reason receptor rs2106809 rs2285666 rs2285666. SARS-CoV-2 SARS-CoV-2 susceptibility SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severity severity of COVID-19 statistically significant study population suggested susceptibility the SARS-CoV-2 virus three group three groups Variation variations with COVID-19 [DOI] 10.1002/jmv.27160 PMC 바로가기 [Article Type] Article
Human Ace D/I Polymorphism Could Affect the Clinicobiological Course of COVID-19인간 에이스 D/I 다형성이 COVID-19의 임상생물학적 경과에 영향을 미칠 수 있음Research Article Published on 2021-09-152022-09-10 Journal: Journal of the Renin-Angiotensin-Aldosterone Syste [Category] 변종, [키워드] ACE ACE gene ACE-2 acute respiratory syndrome Affect allele allele frequency angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 caused Clinical course Clinical outcome clinical outcomes conducted control group coronavirus disease Coronavirus disease 2019 COVID-19 defervescence diagnosed with COVID-19 enrolled essential element Genotype groups Hospitalization Human I/D polymorphism insertion mortality rate not different Patient Pneumonia polymorphism Polymorphisms RAS receptor Renin renin-angiotensin system reported respiratory Result SARS-CoV-2 SARS-CoV-2 virus Severe Acute Respiratory Syndrome Corona Virus severe pneumonia Spread statistically significant susceptibility syndrome the patient time to defervescence virus [DOI] 10.1155/2021/5509280 PMC 바로가기 [Article Type] Research Article
ACE I/D polymorphism and epidemiological findings for COVID-19: One year after the pandemic outbreak in EuropeCorrespondence Published on 2021-09-012022-10-05 Journal: The Journal of Infection [Category] SARS, 유전자 메커니즘, [키워드] ACE epidemiological finding Europe I/D polymorphism outbreak pandemic [DOI] 10.1016/j.jinf.2021.06.002 [Article Type] Correspondence
Impact of I/D polymorphism of angiotensin-converting enzyme 1 (ACE1) gene on the severity of COVID-19 patients코로나19 환자의 중증도에 대한 ACE1(지오텐신 전환 효소 1) 유전자의 I/D 다형성의 영향Article Published on 2021-07-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE ACE I/D polymorphism ACE1 ACE2 ACE2 receptor acute respiratory disease acute respiratory syndrome ADRS allele angiotensin angiotensin I Angiotensin II Angiotensin-converting enzyme association Asymptomatic binding cause Chain Reaction China Clinical outcome Corona virus coronavirus COVID-19 COVID-19 patient detect diabete diabetes disease etiology facilitate followed by Frequency Genotype genotyped host cell hypertension I/D I/D polymorphism Imbalance Impact incidence Interaction Lung injury marker Older age Pathogenesis Patient polymerase chain polymerase chain reaction Predictive researcher respiratory risk RT-PCR SARS-CoV-2 SARS-CoV2 Severe acute respiratory syndrome Severe acute respiratory syndrome corona virus-2 severe COVID-19 severe lung injury severity severity of COVID-19 significantly significantly higher SPSS statistical analysis susceptibility syndrome These data Version [DOI] 10.1016/j.meegid.2021.104801 PMC 바로가기 [Article Type] Article