Recent Advances in Immunomodulatory Therapy in Sepsis: A Comprehensive ReviewAnesthesiology Published on 2024-03-312024-09-05 Journal: Cureus [Category] update2024, [키워드] clinical trials immune dysregulation immunomodulatory therapy Inflammation Sepsis Treatment [DOI] 10.7759/cureus.57309 PMC 바로가기 [Article Type] Anesthesiology
Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus—A Case Report and Literature ReviewReview Published on 2023-12-122024-09-05 Journal: Microorganisms [Category] update2024, [키워드] acute respiratory distress syndrome chemokine profile hantavirus Hantavirus Pulmonary Syndrome immunomodulatory therapy Puumala orthohantavirus [DOI] 10.3390/microorganisms11122963 PMC 바로가기 [Article Type] Review
Friend or foe: RIG- I like receptors and diseasesArticle Published on 2022-10-012022-11-15 Journal: Autoimmunity reviews [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Activation anti-tumor immunity antibody Antiviral antiviral immune response Autoimmune diseases autoinflammatory disease Autoinflammatory diseases Bacterial infections cascade disease Diseases Friend genes encoding Guidance Host IFNs immunomodulatory therapy include involved malaria MDA5 mechanism mechanisms microRNA miRNAs Mutation polymorphism post-translational modification proinflammatory cytokines Proteins recent finding receptor Regulatory RIG-I RLR RLRs RLRs. RNA virus SARS-CoV-2 Signaling single-nucleotide SNPs transcriptional type I interferon [DOI] 10.1016/j.autrev.2022.103161 PMC 바로가기
Tocilizumab therapy in SARS-CoV-2 pneumonia: A matched retrospective cohort analysisSARS-CoV-2 폐렴에서 토실리주맙 요법: 일치된 후향적 코호트 분석Case Reports Published on 2022-06-242022-09-12 Journal: Medicina clínica [Category] COVID19(2023년), SARS, 진단, [키워드] age all-cause mortality Analysis baseline benefit C-reactive protein Clinical improvement Clinical practice Cohort cohort analysis Comorbidities consecutive patient coronavirus disease COVID-19 death decrease English Estudio de cohortes pareadas Evolución group hospital discharge immunomodulatory therapy intravenous tocilizumab Invasive mechanical ventilation Matched Matched cohort study no significant difference outcome Patient rapid normalization receiving retrospective retrospective cohort SARS-CoV-2 severe COVID-19 Severe COVID-19 pneumonia SOC Spanish Standard of care symptoms onset TCZ therapy Tocilizumab Tratamiento inmunomodulador. treated [DOI] 10.1016/j.medcli.2021.06.014 PMC 바로가기 [Article Type] Case Reports
Differential antibody response to COVID-19 vaccines across immunomodulatory therapies for multiple sclerosis다발성 경화증에 대한 면역 조절 요법 전반에 걸친 COVID-19 백신에 대한 차별적인 항체 반응Article Published on 2022-06-012022-09-12 Journal: Multiple sclerosis and related disorders [Category] MERS, 진단, [키워드] 95% CI Acetate Analysis analyzed anti-CD20 anti-CD20 therapy anti-spike antibody antibodies antibody Antibody Response Antibody test Antibody testing B-cell benefit booster vaccinations cells cellular clinical Cohort COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines determine evaluate Final fumarate higher odd humoral identify immunomodulatory effects immunomodulatory therapy Immunosuppressed individual interferons Johnson & Johnson lymphopenia median mediated immunity Moderna mRNA Multiple multiple sclerosis multivariable logistic regression multivariate one patient Patient patients Pfizer phosphate populations positive positive antibody response Post-vaccine predicted predictor reduced SAS significantly Studio Therapies therapy Vaccine vaccine dose Viral vector were used [DOI] 10.1016/j.msard.2022.103737 PMC 바로가기 [Article Type] Article
Efficacy of high-dose intravenous immunoglobulin in severe and critical COVID-19: A retrospective cohort study중증 및 중증 코로나19에서 고용량 정맥 면역글로불린의 효능: 후향적 코호트 연구Article Published on 2022-05-012022-09-12 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 진단, [키워드] 28-day mortality adjusted administration age analyses Analysis analyzed APACHE II score Care chronic respiratory disease COVID-19 COVID-19 disease COVID-19 severity Critical critical COVID-19 patients dysregulated immune response early administration Efficacy evaluate group High-dose hospital ICU ICU admission immunoglobulins immunomodulatory therapy IMPROVE in-hospital mortality initial intensive care Intravenous immunoglobulin invasive ventilation less Linear regression management mechanical ventilation Mortality negativity obesity outcome outcomes Oxygen requirements Patient patient selection performed reduced retrospective cohort study Retrospective study secondary Severe COVID-19 Infection significantly standard treatment supplemental oxygen Ventilation [DOI] 10.1016/j.intimp.2022.108615 PMC 바로가기 [Article Type] Article
Prognostic factors and combined use of tocilizumab and corticosteroids in a Spanish cohort of elderly COVID-19 patients노인 COVID-19 환자의 스페인 코호트에서 예후 인자 및 토실리주맙과 코르티코스테로이드의 병용 사용Observational Study Published on 2022-04-012022-09-12 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] 95% confidence interval addition adjusted Admission age alcohol Analysis analyzed antiplatelet benefit Clinical course Cohort cohort of patient Combined combined use Coronavirus disease 2019 correlated Corticosteroid Corticosteroids COVID-19 COVID-19 disease COVID-19 patient CRP death disease Efficacy efficacy analysis elderly Elderly patient evaluated Factor hazard ratio high-risk patient higher risk hospital identify immunomodulatory therapy Immunosuppressive treatment IMPROVE indicated Infection LASSO Mask Mortality mortality rate multivariate Cox regression Older oxygen support parameter patients older performed Predictive Prognosis Prognostic factor protective factor Regression model shown Spanish standard treatment subsequent survival TCZ Tocilizumab Treatment variable [DOI] 10.1002/jmv.27488 PMC 바로가기 [Article Type] Observational Study
The Fight Against Severe COVID-19: Can Parasitic Worms Contribute?Immunology Published on 2022-02-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Against Can COVID-19 Cytokine storm helminth immunomodulatory therapy SARS-CoV-2 viral sepsis [DOI] 10.3389/fimmu.2022.849465 PMC 바로가기 [Article Type] Immunology
ICU-Associated Costs during the Fourth Wave of the COVID-19 Pandemic in a Tertiary Hospital in a Low-Vaccinated Eastern European CountryArticle Published on 2022-02-042022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Antiviral calculated COVID-19 COVID-19 pandemic Critically ill patient demographic duration of hospitalization dysfunction European Healthcare system healthcare-associated costs hospital ICU identify immunomodulatory therapy increase in intensive care intensive care unit lung involvement management measure medication medication costs non-COVID-19 patient organ dysfunction pandemic Patient patients renal replacement therapy retrospective cohort risk factor Romania SARS-COV-2 infection severity Support Tertiary Treatment Wave were recorded [DOI] 10.3390/ijerph19031781 PMC 바로가기 [Article Type] Article
Therapeutic implications of ongoing alveolar viral replication in COVID-19Review article Published on 2022-02-012022-10-05 Journal: The Lancet Rheumatology [Category] 변종, [키워드] alveolar approach autoimmune responses benefit blunting Corticosteroid COVID-19 Critical disease disease excessive inflammatory response heterogeneity highlight immunomodulatory therapy immunopathology Immunosuppression Immunotherapy immunothrombosis implication individual innate immune response interleukin-6 receptor Lungs Mild moderate-to-severe COVID-19 moderate-to-severe COVID-19 pneumonia Oxygen therapy Patient patients treated SARS-CoV-2 clearance SARS-CoV-2 replication T-cell responses therapeutic therapy thought Ventilation viral replication [DOI] 10.1016/S2665-9913(21)00322-2 [Article Type] Review article