Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline: caution is warrantedArticle Published on 2024-01-162024-09-05 Journal: eBioMedicine [Category] update2024, [키워드] COVID-19 epitope mapping in silico prediction neutralizing antibody SARS-CoV-2 [DOI] 10.1016/j.ebiom.2023.104960 PMC 바로가기 [Article Type] Article
Thrombosis-related circulating miR-16-5p is associated with disease severity in patients hospitalised for COVID-19혈전증 관련 순환 miR-16-5p는 COVID-19로 입원한 환자의 질병 중증도와 관련이 있습니다Article Published on 2022-01-012022-09-11 Journal: RNA Biology [Category] 바이오마커, [키워드] 95% CI ACE2 ACE2 receptor activated acute respiratory syndrome acute respiratory syndrome coronavirus Admission amyloid amyloid beta Analysis angiotensin Angiotensin-converting enzyme app approach Area baseline baseline expression Beta bioinformatic analysis bioinformatics Bioinformatics analysis Biomarker Blood Blood cells body mass CALM1 calmodulin can be used changes in chronic obstructive circulating class Co-expression analysis Coagulation composite endpoint condition Control Coronary artery coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 complications COVID-19 patient cyclin dataset death diabete diabetes Diabetes Mellitus diagnostic disease disease severity EGFR ELAVL1 enzyme expression expression level expression levels expressions family Fibronectin Filamin FLNA FN1 Follow-up Gene Expression Genes growth factor healthy controls healthy volunteer heat Heat shock heat shock protein hospital hospitalised hospitalized COVID-19 patient HSP90AA1 Human hypercoagulable in silico in silico prediction independent predictor independent predictors individual inflammatory reaction intensive care interquartile let-7b-5p Like member microRNA MicroRNAs miR-155 miR-16-5p miRNA miRNAs Multivariate analysis Myocardial nuclear pathway Pathways Patient patients hospitalized patients with COVID-19 performed peripheral Peripheral blood phosphatase play role polymerase chain positive Predictive prognostic biomarker Prognostic biomarkers Protein PTEN qRT-PCR Quantitative receptor Regulatory RNA SARS-CoV-2 selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Severity of infection silico prediction silico predictions Stratification tensin the healthy THROMBOPLASTIN thrombosis thrombotic Toll-like receptor TP53 UBC ubiquitin utility White blood cells [DOI] 10.1080/15476286.2022.2100629 PMC 바로가기 [Article Type] Article
Development of highly stable and de-immunized versions of recombinant alpha interferon: Promising candidates for the treatment of chronic and emerging viral diseasesArticle Published on 2021-12-012023-06-13 Journal: Clinical immunology (Orlando, Fla.) [Category] B형 간염, SARS, [키워드] Alpha interferon antiviral therapy COVID-19 De-immunization in silico prediction T cell epitope [DOI] 10.1016/j.clim.2021.108888 PMC 바로가기
Epitope mapping from Mycobacterium leprae proteins: Convergent data from in silico and in vitro approaches for serodiagnosis of leprosyarticle Published on 2021-10-312024-09-01 Journal: Molecular Immunology [Category] 한센병, [키워드] epitope mapping Immunodiagnosis immunoinformatics in silico prediction leprosy synthetic peptide [Article Type] article
In Vitro Inhibitory Analysis of Rationally Designed siRNAs against MERS-CoV Replication in Huh7 CellsArticle Published on 2021-04-292022-10-30 Journal: Molecules [Category] COVID-19, MERS, [키워드] antiviral efficacy antiviral therapy approach Camel can be used cell line cell lines Combination confirmed case country cytotoxicity death designing develop disease-causing effective evaluate evaluated filtration high accuracy Hospitalized Huh7 HUH7 cells Huh7cells in silico prediction in vitro in vitro study in vivo information Jeddah MERS-CoV ORF1ab gene Patient predict prevalent Replication RNAfold Safe Saudi Arabia secondary structure selected siRNA siRNAs specificity spread to Transmission viral replication virus viruses was performed was used [DOI] 10.3390/molecules26092610 PMC 바로가기 [Article Type] Article
De-immunized and Functional Therapeutic (DeFT) versions of a long lasting recombinant alpha interferon for antiviral therapyArticle Published on 2017-03-012023-06-19 Journal: Clinical immunology (Orlando, Fla.) [Category] B형 간염, [키워드] De-immunization Hepatitis therapy IFN alpha IFN-α immunogenicity in silico prediction T cell epitope T-cell proliferation assay. [DOI] 10.1016/j.clim.2017.01.003