Decavanadate interactions with the elements of the SARS-CoV-2 spike protein highlight the potential role of electrostatics in disrupting the infectivity cycleSARS-CoV-2 스파이크 단백질 요소와의 Decavanadate 상호 작용은 감염 주기를 방해하는 정전기의 잠재적 역할을 강조합니다Article Published on 2022-09-012022-09-11 Journal: Journal of inorganic biochemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral agent approach association binding biological properties biological property carried collected data coronavirus COVID-19 cytotoxicity decrease disrupt disrupting drug design effective Effectiveness effort electrostatic force electrostatic forces element ENhance Evidence furin furin cleavage site highlight Host host cell host cell membrane identify In vitro studies in vitro study infected cells Interaction interactions less mass spectrometry molecular Native Novel coronavirus Polyanion polybasic Polyoxidometalate Protein Protein binding Proteolytic processing provide receptor Receptor-binding domain robust robustness Safe SARS-CoV-2 entry SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-CoV-2 spike protein shown Spike protein the receptor-binding domain the SARS-CoV-2 the spike protein therapeutic therapeutic agent therapeutic agents Therapeutics utility Vanadium variety Viral mutations while [DOI] 10.1016/j.jinorgbio.2022.111899 PMC 바로가기 [Article Type] Article
Protective role of zinc in the pathogenesis of respiratory diseases Reviews Published on 2022-08-182022-10-05 Journal: European journal of clinical nutrition [Category] 치료제, [키워드] Analysis Anti-inflammatory antioxidant Antiviral Apoptosis cancer cell disease Effect highlight immune In vitro studies Inflammation inhibit lipid metabolism Lung diseases Lungs morbidity and mortality oxidative stress Pathogenesis Perspective Protective effects protective mechanism provide regulate Regulation Research respiratory Respiratory disease respiratory diseases subjects therapy variety [DOI] 10.1038/s41430-022-01191-6 [Article Type] Reviews
Ozone treatment effectively eliminates SARS-CoV-2 from infected face masks오존 처리는 감염된 안면 마스크에서 SARS-CoV-2를 효과적으로 제거합니다.Article Published on 2022-07-222022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] B.1.1.7 Chain Reaction collected Concentration COVID-19 pandemic COVID-19 patient COVID-19 patients demonstrated described dosage Effect Efficiency Emergency evaluate face Face mask Face masks Health hospitalized patient hospitalized patients In vitro studies inactivated inactivation infected with SARS-CoV-2 Mask Masks outbreak Ozone Personal protective equipment polymerase chain polymerase chain reaction PPE PPM problem Quantitative RT-qPCR SARS-CoV-2 SARS-CoV-2 strain Social problems treated Treatment Viral RNA virus inactivation Volume [DOI] 10.1371/journal.pone.0271826 PMC 바로가기 [Article Type] Article
Imaging Techniques: Essential Tools for the Study of SARS-CoV-2 Infection영상 기술: SARS-CoV-2 감염 연구를 위한 필수 도구Review Published on 2022-07-222022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] COVID-19 COVID-19 pandemic death diagnostic Essential fluorescence microscopy functional functional studies high content screening high resolution Host imaging In vitro studies in vitro study Interaction Microscopy models new virus observation patients power reagent reagents RT-PCR SARS-CoV-2 SARS-CoV-2 detection Super-resolution Viral protein Viral proteins Virology virus [DOI] 10.3389/fcimb.2022.794264 PMC 바로가기 [Article Type] Review
Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strainsSARS-CoV-2 Omicron 계통 균주에 의한 감염에 대한 S309 및 AZD7442 단일클론 항체 치료의 회복력Article Published on 2022-07-022022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acting Antibody neutralization AstraZeneca Cell culture changes in Combination correlation analyses Correlation analysis Effect Efficacy Express FcγR hACE2 human ACE2 humans in vitro In vitro studies in vitro study in vivo Infection Interaction K18-hACE2 Lineage Lung infection mAb mechanism mice monoclonal antibody monoclonal antibody therapies monoclonal antibody treatment monotherapy neutralization neutralization potency Neutralizing activity omicron Omicron variant Omicron variants Prevent Prophylactic Protective reduced reductions reductions in Resilience retained S309 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 isolates SARS-CoV-2 variant Spike protein strain suggested susceptible the spike protein therapeutic therapy transgenic mice treat Treatment variant variants Viral viral burden [DOI] 10.1038/s41467-022-31615-7 PMC 바로가기 [Article Type] Article
COVID-19 patient with B Cell Lymphoma co-morbidity managed with co-administration of Ayurvedic formulationCase report Published on 2022-07-012022-10-05 Journal: Journal of Ayurveda and Integrative Medicine [Category] 진단, 치료제, [키워드] Achyranthe Ageusia Aloe Anti-viral antipyretics Antiviral approach Ayurveda Cancer chemotherapy cycle chronic co-morbidity condition COVID-19 COVID-19 pandemic COVID-19 patient Diagnosis Eclipta Efficacy Embelia Fever First wave glycyrrhiza home quarantine Host immune response host response Immunocompromised immunocompromised status immunomodulatory In vitro studies infective Intervention Kidney disease lymphoma malaise male modulate oxygen saturation Patient positive regimen remained replicated respiratory complication RT-PCR supported took place treat treated Vitamin was done [DOI] 10.1016/j.jaim.2022.100632 [Article Type] Case report
COVID-19 Infection in Children and Infants: Current Status on Therapies and VaccinesReview Published on 2022-02-122022-10-31 Journal: Children [Category] COVID-19, [키워드] Affect age antibodies approved children clinical clinical trial COVID-19 current dentistry Efficacy Epidemiology Evidence Frame In vitro studies Infant Infection literature review majority mechanism mild symptoms outbreak Pfizer Pregnancy produced required reservoir SARS-CoV-1 SARS-CoV-2 status Support the SARS-CoV-2 therapy Transmission Trial vaccination Vaccine Vaccines Variation vector was performed World Health Organization [DOI] 10.3390/children9020249 PMC 바로가기 [Article Type] Review
Very low levels of remdesivir resistance in SARS-COV-2 genomes after 18 months of massive usage during the COVID19 pandemic: A GISAID exploratory analysisCOVID19 전염병 동안 18개월 동안 대량 사용 후 SARS-COV-2 게놈에서 매우 낮은 수준의 렘데시비르 내성: GISAID 탐색 분석Article Published on 2022-02-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Analysis Antiviral Antiviral compound Antiviral compounds controlled trials COVID-19 COVID19 E802D Efficacy effort Emergency use authorization Exploratory analysis fitness Frequency Genome GISAID GISAID database hospitalized patients In vitro studies in vivo inhibitor massive molnupiravir mutations Nsp12 pandemic Randomized controlled trial Randomized controlled trials RdRP RdRp mutation RdRp mutations Remdesivir resistance reveal RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 sequencing Strains Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1016/j.antiviral.2022.105247 PMC 바로가기 [Article Type] Article
Pharmacoepidemiology, Machine Learning, and COVID-19: An Intent-to-Treat Analysis of Hydroxychloroquine, With or Without Azithromycin, and COVID-19 Outcomes Among Hospitalized US Veterans약물역학, 기계 학습 및 COVID-19: 아지트로마이신 유무에 관계없이 하이드록시클로로퀸의 치료 의도 분석 및 입원한 미국 재향 군인의 COVID-19 결과Article Published on 2021-11-022022-09-11 Journal: American journal of epidemiology [Category] SARS, 임상, [키워드] 95% confidence interval administration Affair Analysis Azithromycin benefit Care cause Combination coronavirus disease Coronavirus disease 2019 COVID-19 Department Effect Effectiveness Electronic health record Evidence evidence of examined gradient boosting hazard ratio HCQ Health Health care Health care system health record Hospitalization Hospitalized Hydroxychloroquine imputation In vitro studies in vitro study in vivo increased risk indicated individual intubation machine learning Missing data National no evidence of observational study patients hospitalized pharmacoepidemiology positive Propensity score randomized clinical trial reduce reported Study design survival survival analysis tested therapy Treatment treatment of COVID-19 Treatment outcome veteran virus was used with COVID-19 [DOI] 10.1093/aje/kwab183 PMC 바로가기 [Article Type] Article
Hydroxychloroquine plus azithromycin early treatment of mild COVID-19 in an outpatient setting: a randomized, double-blinded, placebo-controlled clinical trial evaluating viral clearance외래 환자 환경에서 경증 COVID-19의 하이드록시클로로퀸과 아지스로마이신 조기 치료: 바이러스 제거를 평가하는 무작위, 이중 맹검, 위약 대조 임상 시험Randomized Controlled Trial Published on 2021-11-012022-09-11 Journal: International journal of antimicrobial agents [Category] 임상, 치료법, 치료제, [키워드] 95% CI adverse effects Analysis Azithromycin cardiovascular event Chest computed tomography clearance rate clinical evolution Comorbidities Computed tomography conducted Controlled clinical trial COVID-19 criteria demographic characteristics double-blinded early treatment Efficacy Endpoint enrolled enrolment evaluated Evolution group Hospitalization Hydroxychloroquine hydroxychloroquine plus azithromycin in some in viral In vitro studies inclusion criteria intention-to-treat Mild mild SARS-CoV-2 infection outcome Outpatient outpatients participant Patient per-protocol performed Placebo placebo-controlled clinical trial POCT positive PP analysis primary endpoint randomised Randomized RCT reducing SARS-CoV-2 SARS-COV-2 infection screening test secondary Secondary endpoints Secondary outcomes shown significantly statistical analyses statistically significant Support Swab Symptom Treatment trial participants viral clearance viral clearance rate viral clearance rates Viral load viral load reduction viral loads viral replication [DOI] 10.1016/j.ijantimicag.2021.106428 PMC 바로가기 [Article Type] Randomized Controlled Trial