Can We Exploit Inflammasomes for Host-Directed Therapy in the Fight against Mycobacterium tuberculosis Infection?Review Published on 2024-07-272024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] gene editing host response host-directed therapy inflammasomes Inflammation M. tuberculosis medicinal plants [DOI] 10.3390/ijms25158196 PMC 바로가기 [Article Type] Review
Differential effects of acute and chronic hydrocortisone treatment on pyroptosisResearch Article Published on 2024-05-112024-09-05 Journal: Heliyon [Category] update2024, [키워드] Hydrocortisone IL-1β inflammasomes macrophages pyroptosis [DOI] 10.1016/j.heliyon.2024.e31156 PMC 바로가기 [Article Type] Research Article
The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspasesIL-18과 IL-1β의 테트라펩타이드 서열은 염증성 카스파제에 의한 이들의 모집과 활성화를 조절한다.Article Published on 2023-12-262024-08-21 Journal: Cell Reports [Category] 살모넬라증, [키워드] caspase-1 caspase-11 Caspase-4 Caspase-5 CP: Immunology Cytokines IL-18 IL-1β inflammasomes pyroptosis
Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infectionArticle Published on 2022-09-162022-11-16 Journal: Science Advances [Category] SARS, 신약개발, [키워드] acute respiratory syndrome AIM2 Asymptomatic COVID-19 autophagy coronavirus COVID-19 develop disease FDA-approved drug human monocyte identification immunomodulatory drug immunomodulatory function impair implicated in vitro in vivo independent induce Inflammasome inflammasome activation inflammasomes inflammatory process information inhibit inhibited inhibitors Mild NIC NLRP3 NLRP3 inflammasome Patient patients with COVID-19 PBMC performed provide SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication treat Treatment [DOI] 10.1126/sciadv.abo5400 PMC 바로가기
Defining resistance and tolerance traits in Covid-19: towards a stratified medicine approachCovid-19의 내성 및 내성 특성 정의: 계층화된 의학 접근 방식Article Published on 2022-08-132022-09-11 Journal: QJM: An International Journal of Medicine [Category] SARS, 변종, [키워드] activated anti-Spike IgG approach Auto-antibodies CCR2 component coronavirus disease Coronavirus disease 2019 COVID-19 pathogenesis Deleterious failure Genetic Genetic variant genotypic GM-CSF heterogeneity highlight Highlights Host Host-directed therapies Human IFN-I IFN-α IFNA10 IFNAR2 IL-6 infection with SARS-CoV-2 Infectious disease inflammasomes inflammatory lung injury integration Inter-individual variation life-threatening coronavirus disease lung Lung injury M-CSF macrophages MCP-1 Monocyte-derived macrophages Monocytes neutralizing auto-antibodies neutralizing auto-antibody NLRP1 pathogen Pathogenesis periphery PLSCR1 pro-inflammatory pro-inflammatory response progression recruited reduce regulate response responses resulting reticuloendothelial system SARS-COV-2 infection stratified the disease therapeutic tissue damage Tolerance treatable TYK2 type 1 interferon virus-independent immunopathology [DOI] 10.1093/qjmed/hcac143 PMC 바로가기 [Article Type] Article
Spontaneous NLRP3 inflammasome-driven IL-1-β secretion is induced in severe COVID-19 patients and responds to anakinra treatmentResearch article Published on 2022-07-012022-10-05 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] Activation acute respiratory syndrome Analysis analyzed Anti-inflammatory therapy apoptotic ASC Blood cDNA cell line circulating monocyte circulating monocytes coding confocal microscopy coronavirus COVID-19 Critically ill cytokine cytokine secretion Cytokine storm syndrome disease dissect driving effective Efficacy Evidence Frame IL-1 receptor antagonist IL-1β in vitro Infection Inflammasome inflammasomes Inflammation Inflammatory inflammatory parameters manifestation maturation mechanism NLRP3 NLRP3 inflammasome objective ORF3a pathway Patient patients with COVID-19 Phenotypes Plasma cytokine receptor protein reducing mortality regulated respond Result RNA sequencing SARS-CoV-2 SARS-CoV-2 protein secrete secretion severe coronavirus disease severe COVID-19 patient severe pneumonia shown Spontaneous transfection Treatment Trigger with COVID-19 [DOI] 10.1016/j.jaci.2022.05.029 [Article Type] Research article
How to Restore Oxidative Balance That Was Disrupted by SARS-CoV-2 InfectionSARS-CoV-2 감염으로 교란된 산화 균형을 회복하는 방법Review Published on 2022-06-072022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition angiotensin antioxidant antioxidants Antioxidative balance caused Clinical studies clinical study complex coronavirus coronavirus 2019 disease Course COVID-19 COVID-19 pathogenesis cytokine Cytokine storm demonstrated detrimental disease Disrupted drug dysregulated Effect expression glutathione GSH homeostasis Immunological response Impact induce Inflammasome inflammasomes inhibit mechanism NLRP3 Nrf2 nuclear outcome oxidative oxidative stress oxygen Prevent Protective Protein protein 3 reactive oxygen species reactive oxygen specy Renin renin angiotensin system ROS SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown stimulate the disease variant variety virus [DOI] 10.3390/ijms23126377 PMC 바로가기 [Article Type] Review
SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1SARS-CoV-2 비구조 단백질 6은 ATP6AP1을 표적으로 하여 NLRP3 의존성 발열을 유발합니다Article Published on 2022-06-012022-09-11 Journal: Cell Death and Differentiation [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] abrogated activated Activation acute respiratory syndrome coronavirus Analysis Asymptomatic COVID-19 ATP6AP1 ATPase autophagic flux binding caspase-1 coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated epithelial cells exhibited impair induce Infection Inflammasome inflammasome activation inflammasomes inflammatory cell Inflammatory cell death inhibit inhibited interleukin L37F live SARS-CoV-2 lung epithelial cell Lung epithelial cells lung tissues lysosome acidification maturation metformin Mutation NLRP3 non-structural protein NSP6 overexpression Patient pharmacological Polydatin proton pump pyroptosis receptor signaling reduced respiratory SARS-CoV-2 serological markers severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 suggested Support Transcriptome transcriptome analysis Trigger triggered upstream vacuolar variant viral pathogenicity weakened [DOI] 10.1038/s41418-021-00916-7 PMC 바로가기 [Article Type] Article
Inflammasome activation in infected macrophages drives COVID-19 pathology감염된 대식세포의 인플라마좀 활성화는 COVID-19 병리를 유발합니다Article Published on 2022-06-012022-09-12 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] ACE2 receptors activate Activation antibody attenuate blockade blocking cascade CD16 characterized contributing to COVID-19 COVID-19 pathology Critical disease downstream host infection Human immune system human macrophage humanized hyperinflammatory state IFN IL-1 IL-18 immune in vivo Infection Infectious virus Inflammasome inflammasome activation inflammasomes Inflammatory cytokine inflammatory cytokine production inflammatory macrophages Inflammatory response interferon Lung inflammation Lung pathology Lungs Macrophage macrophages NLRP3 inflammasome overactive pathology pathway Prevent pyroptosis Remdesivir Replication required SARS-CoV-2 SARS-COV-2 infection Stage sustained undergo viral replication Viral RNA [DOI] 10.1038/s41586-022-04802-1 PMC 바로가기 [Article Type] Article
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation Research Published on 2022-04-062022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 바이오마커, 변종, 신약개발, 치료기술, 치료법, 치료제, [키워드] abort activate activated Activation acute respiratory distress AIM2 Autopsy blood monocyte caspase-1 cause Cell contribute COVID-19 pathogenesis Culture death endothelial cells epithelial gasdermin D infected cell infected with SARS-CoV-2 Infection Infectious virus Inflammasome inflammasomes Inflammation Inflammatory Inflammatory cell death invasive lung Macrophage monocyte Monocytes NLRP3 patients with COVID-19 plasma promote pyroptosis receptors recipient replicate SARS-CoV-2 SARS-COV-2 infection severe COVID-19 supernatant systemic inflammation tissue-resident macrophages Trigger undergo Vaccine virus [DOI] 10.1038/s41586-022-04702-4 [Article Type] Research