Isoprinosine as a foot-and-mouth disease vaccine adjuvant elicits robust host defense against viral infection through immunomodulationarticle Published on 2024-03-062024-09-05 Journal: Frontiers in Cellular and Infection Microbiology [Category] update2024, [키워드] adjuvant foot-and-mouth disease host defense innate and adaptive immunity isoprinosine Vaccine [DOI] 10.3389/fcimb.2024.1331779 PMC 바로가기 [Article Type] article
The roles of innate and adaptive immunity in inactivated viral vaccination‐mediated protection against COVID‐19Commentary Published on 2024-01-152024-09-05 Journal: Clinical and Translational Medicine [Category] update2024, [키워드] COVID‐19 inactivated viral vaccination innate and adaptive immunity trained immunity [DOI] 10.1002/ctm2.1530 PMC 바로가기 [Article Type] Commentary
Immunotherapeutic approaches for systemic lupus erythematosus: early overview and future potentialReview Published on 2023-10-102024-09-04 Journal: Medical review [Category] 대상포진, [키워드] Immunotherapy innate and adaptive immunity systemic lupus erythematosus [DOI] 10.1515/mr-2023-0032 PMC 바로가기 [Article Type] Review
Targeting the Complement-Sphingolipid System in COVID-19 and Gaucher Diseases: Evidence for a New Treatment StrategyReview Published on 2022-11-182024-09-02 Journal: International Journal of Molecular Sciences [Category] 대상포진, [키워드] Inflammation innate and adaptive immunity Lipid rare-genetic disease viral infection [DOI] 10.3390/ijms232214340 PMC 바로가기 [Article Type] Review
Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and TherapeuticsCOVID-19의 기계론적 모델: 질병 진행, 백신 및 치료제에 대한 통찰력Review Published on 2022-07-012022-09-11 Journal: International journal of antimicrobial agents [Category] 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] adaptive antiviral therapeutics antiviral therapy COVID-19 COVID-19 pandemic COVID-19 vaccines Critical develop Effectiveness global effort health system health systems Immunity Immunomodulatory agents impacted IMPROVE Infection innate and adaptive immunity insight mechanism Model outcome pandemic provided Quantitative quantitative systems pharmacology SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 variants Significant Therapeutics Transmission Vaccine Vaccines viral dynamics Viral dynamics models. [DOI] 10.1016/j.ijantimicag.2022.106606 PMC 바로가기 [Article Type] Review
Dysregulated Immune Responses in SARS-CoV-2-Infected Patients: A Comprehensive OverviewSARS-CoV-2 감염 환자의 조절되지 않은 면역 반응: 종합 개요Review Published on 2022-05-182022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus adaptive alteration Antigen antigen-presenting cell antiviral immune responses B cell subset Biomarker caused CD8+ CD8+ T cell cellular cellular immunity complications of COVID-19 Comprehensive comprehensive analysis coronavirus country COVID-19 COVID-19 patients disease effective evade follicular follicular Th cell help Host Human humoral Humoral immunity identify immune responses Immunity IMPROVE Infection Inflammatory information innate and adaptive immunity involved knowledge mechanism molecular mechanism monocyte new virus outcomes pathological change pathological changes Phenotypes Post-COVID-19 syndrome predict recognize Research response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity Symptom syndrome T cell Th cell Th cell subsets Th17 the SARS-CoV-2 variety [DOI] 10.3390/v14051082 PMC 바로가기 [Article Type] Review
Antiviral therapy for COVID-19: Derivation of optimal strategy based on past antiviral and favipiravir experiencesReview Published on 2022-02-012023-06-30 Journal: Pharmacology & therapeutics [Category] COVID19(2023년), SARS, [키워드] antiviral therapy COVID-19 Favipiravir innate and adaptive immunity RNA dependent RNA polymerase SARS-CoV-2 [DOI] 10.1016/j.pharmthera.2022.108121 PMC 바로가기 [Article Type] Review
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19단일 세포 다중 오믹스는 진행성 COVID-19에서 선천 면역 체계와 적응 면역 체계의 불일치를 나타냅니다.Article Published on 2022-01-212022-09-12 Journal: Nature Communications [Category] 바이오마커, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] activated adaptive adaptive immune system Analysis approach B cell CD8 Cell cellular cellular immunity classical monocyte classical monocytes clone clones Course COVID-19 Disease progression dysregulated immune response dysregulated immune responses Effect Frequency Gene Expression hallmark hallmarks highlight hospitalized patient hospitalized patients immune immune profiling immune response immune responses immune signature Immunity immunopathology information innate and adaptive immunity Interaction LAG-3 Lineage marker Monocytes mutated pathology patients patients with COVID-19 probe progressive COVID-19 progressive disease Protein reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severe COVID-19 single-cell skewed Systems analysis T cell T cell receptor T cells the SARS-CoV-2 virus Tocilizumab viral infection [DOI] 10.1038/s41467-021-27716-4 PMC 바로가기 [Article Type] Article
SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges소아 집단에 대한 SARS-CoV-2 백신 테스트 및 시험: 생물학적, 윤리적, 연구 및 구현 과제Article Published on 2021-11-012022-09-11 Journal: Pediatric Research [Category] SARS, 임상, [키워드] accelerate adaptive addressed Adolescence Adults Affect affected allocation approach biologic Care changes in childhood children chronic conditions chronic disease clinical trial clinical trials Community conditions COVID-19 COVID-19 disease COVID-19 pandemic developmental developmental disorder developmental disorders Diseases Effect effective Effectiveness enrolled equity ethical concerns Health health inequities health system immune immune system Immunity implementation include innate and adaptive immunity knowledge majority maturation nation other disease other diseases pediatric populations rationale required Research risk SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines symptomatic threshold Trial unique vaccination Vaccinations Vaccine Vaccine hesitancy variety weighed [DOI] 10.1038/s41390-021-01402-z PMC 바로가기 [Article Type] Article
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severityCOVID-19 질병 심각도의 위험 바이오 마커로서 비타민 D- 관련 다형성 및 비타민 D 수준Multicenter Study Published on 2021-10-212022-09-01 Journal: Scientific Reports [Category] MERS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료법, [키워드] activating adaptive Admission AMDHD1 analysed association binding Biomarker characterized Concentration correlation COVID-19 disease severity COVID-19 patients COVID-19 severity CYP24A1 CYP2R1 deficiency DHCR7 disease severity enrolled European population explain genetic background genetic susceptibility genetic variants hospital hospitals Host Immunity Immunogenetics infected with SARS-CoV-2 Infection innate and adaptive immunity outcome Pathways Patient polymorphism Polymorphisms Predictive markers Prevalence Protein Research risk Risk factors SEC23A serum severity survival Trial registration variant variants VDR Viral diseases viral infection Vitamin Vitamin D vitamin D deficiency vitamin D level vitamin D pathway was measured [DOI] 10.1038/s41598-021-99952-z PMC 바로가기 [Article Type] Multicenter Study