Genetic Influences of Proinflammatory Cytokines on Pain Severity in Patients with Temporomandibular DisordersArticle Published on 2024-08-102024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] chronic pain Cytokines Inflammation interleukin-8 Single nucleotide polymorphism temporomandibular disorders [DOI] 10.3390/ijms25168730 PMC 바로가기 [Article Type] Article
Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS)Article Published on 2024-07-182024-09-05 Journal: Vaccines [Category] update2024, [키워드] Cognitive impairment interleukin-6 interleukin-8 malaise/chronic fatigue PACVS peripheral nerve dysfunction Post-acute COVID-19 vaccination syndrome [DOI] 10.3390/vaccines12070790 PMC 바로가기 [Article Type] Article
Interleukin-8 predicts short-term mortality in acute-on-chronic liver failure patients with hepatitis B-related-related cirrhosis backgroundHepatology Published on 2023-12-052024-09-05 Journal: Annals of Medicine [Category] update2024, [키워드] Acute-on-chronic liver failure cirrhosis interleukin-8 predictive models Prognosis [DOI] 10.1080/07853890.2023.2287708 PMC 바로가기 [Article Type] Hepatology
The Role of Interleukin-8 in Lung Inflammation and Injury: Implications for the Management of COVID-19 and Hyperinflammatory Acute Respiratory Distress SyndromePharmacology Published on 2022-01-122022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ARDS Biomarker Complication COVID-19 CXCR1/2 Cytokine storm disease disease pathogenesis effective help highlight Hyperinflammatory IL-8 increase in interleukin Interleukin 8 (IL-8) interleukin-8 lack Lung inflammation modulate modulating NETs neutrophil activation Neutrophils Pathogenesis phenotype pro-inflammatory cytokine Prognostic factor progression respiratory role SARS CoV-2 Spread therapeutic option Therapeutic strategies therapeutic target [DOI] 10.3389/fphar.2021.808797 PMC 바로가기 [Article Type] Pharmacology
Evaluation of minocycline combined with favipiravir therapy in coronavirus disease 2019 patients: A case-series study코로나바이러스 질환 2019 환자에서 파비피라비르 요법과 결합된 미노사이클린의 평가: 사례 시리즈 연구Article Published on 2022-01-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 치료제, [키워드] acute respiratory syndrome adverse event anti-inflammatory activity antibacterial activity Antiviral Chain Reaction changes in chemokine combination therapy Control control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine cytokine and chemokine production Cytokines duration of fever duration of hospitalization Efficacy and safety Endpoint evaluated Favipiravir greater groups hospital Inflammatory cytokines interleukin interleukin-6 interleukin-8 Japan MIN Minocycline monotherapy Negative PCR no difference Patient PCR test polymerase chain polymerase chain reaction reduction reported Retrospective study SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe case severe cases significantly significantly shorter Support therapy Treatment treatment initiation [DOI] 10.1016/j.jiac.2021.09.016 PMC 바로가기 [Article Type] Article
Extracellular Vesicle Associated miRNAs Regulate Signaling Pathways Involved in COVID-19 Pneumonia and the Progression to Severe Acute Respiratory Corona Virus-2 Syndrome세포 외 소포 관련 miRNA는 COVID-19 폐렴에 관여하는 신호 전달 경로를 조절하고 심한 급성 호흡기 코로나 바이러스 -2 증후군으로의 진행Immunology Published on 2021-12-092022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] ACE2 expression activated adjusted alveolar cell among others Analysis analyzed ARDS ARDS patients bind Biomarker Biomarkers carrier carriers Cell cell-free microRNAs cell-to-cell communication cells circulating community acquired pneumonia controls Corona COVID-19 COVID-19 ARDS patient COVID-19 pneumonia CXCL8 Differential gene expression differential gene expression analysis differentially expressed miRNA downregulated epithelial evaluated EVs Extracellular vesicles function group healthy control healthy controls IL6 increase Inflammatory inhibited interleukin interleukin-6 interleukin-8 investigated let-7e-5p log2FC lung Lung diseases mechanically ventilated patient mediators miR-146 miR-146a-5p miRNA miRNAs mRNA mRNA transcript mRNA transcripts nasal epithelium network network analysis neutrophil neutrophil recruitment olfactory OR52N2 pathophysiology Pathways Pneumonia Precipitation prospectively studied receptor regulate regulated respiratory Result resulting RNA sequencing SARS-CoV-2 spike protein secrete Sepsis Severe Acute Respiratory Corona Virus-2 Syndrome severe COVID-19 Signaling signaling pathway significantly small RNA small RNA sequencing Spike protein symptomatic patient syndrome the healthy therapeutic targets TLR4 Toll-like receptor toll-like receptor 4 total RNA transcript upregulated Vesicle with COVID-19 [DOI] 10.3389/fimmu.2021.784028 PMC 바로가기 [Article Type] Immunology
Skewed Cytokine Responses Rather Than the Magnitude of the Cytokine Storm May Drive Cardiac Dysfunction in Multisystem Inflammatory Syndrome in Children사이토카인 폭풍의 크기보다는 편향된 사이토카인 반응이 어린이의 다기관 염증 증후군에서 심장 기능 장애를 유발할 수 있음Article Published on 2021-08-172022-09-11 Journal: Journal of the American Heart Association [Category] 바이오마커, [키워드] absolute levels Acute stress analyzed association cardiac Cardiomyopathy children controls correlated COVID‐19 cytokine Cytokine storm Cytokines deformation diastolic drive driven by dysfunction echocardiographic parameter echocardiographic parameters echocardiography Elevation elevations etiology evaluated explained expression feature hypercytokinemia hyperinflammation immune response impairment Inflammatory interleukin interleukin-6 interleukin-8 involved microangiopathy MIS-C multisystem inflammatory syndrome in children Myocardial myocardial deformation. Myocardial function myocardial involvement outcome parameter Pathways Primary outcomes profile profiles proinflammatory cytokines response Result severity Shock storm strain syndrome systolic ventricular [DOI] 10.1161/JAHA.121.021428 PMC 바로가기 [Article Type] Article
Revealing the therapeutic targets and molecular mechanisms of emodin-treated coronavirus disease 2019 via a systematic study of network pharmacology네트워크 약리학에 대한 체계적인 연구를 통해 2019 년 에모딘 처리 된 코로나 바이러스 질병의 치료 표적 및 분자 메커니즘을 드러냅니다.Research Paper Published on 2021-06-152022-09-10 Journal: Aging (Albany NY) [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 B-cell B-cell lymphoma Bacterial BCL2L1 bioinformatics Biomarker Biomarkers Cancer candidate gene CASP3 caspase caspase-3 colony stimulating factor complications coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 CSF2 CXCL8 developmental Diabetic diabetic complications docking Effect EGFR emodin endothelial epidermal epidermal growth factor exhibited Factor GO analysis growth factor IL-17 IL1B Infection interleukin interleukin-8 involved KEGG leads lipopolysaccharide MAPK MAPK signaling MAPK1 MAPK14 MCL1 mitogen mitogen-activated protein kinase molecular molecular docking molecular mechanism molecular mechanisms molecule myeloid cell Necrosis network pharmacology pathway Pathways pertussis pharmacological pharmacological mechanism pharmacological target Protein protein kinase Proteoglycan proteoglycans PTGS2 RAGE receptor receptor signaling reproduction reproductive respiratory screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown signaling pathway suggested target targets therapeutic target TNF TNF signaling TP53 treating COVID-19 Treatment treatment of COVID-19 Tumor tumor necrosis tumor necrosis factor Vascular VEGFA [DOI] 10.18632/aging.203098 PMC 바로가기 [Article Type] Research Paper
Induction of the Proinflammatory Chemokine Interleukin-8 Is Regulated by Integrated Stress Response and AP-1 Family Proteins Activated during Coronavirus InfectionArticle Published on 2021-05-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] acute respiratory syndrome antiviral immunity AP-1 AP-1 family proteins caused Cell cellular chemokine cJUN and cFOS complex interaction coronavirus coronavirus disease Coronavirus infection COVID-19 Cytokine release syndrome demonstrated double-stranded eIF2α eIF2α epidemic diarrhea eukaryotic translation facilitate family highlighting IBV IBV-infected cells IL-6 IL-8 induce induction Infection Infectious Bronchitis Virus innate immune response integrated stress response interleukin-8 investigated life-threatening Local mRNA expression mutant overexpression pathway PKR Proinflammatory cytokine Protein Regulatory response SARS-CoV-2 Severe case significantly Stress unfolded protein response upregulation upstream virus [DOI] 10.3390/ijms22115646 PMC 바로가기 [Article Type] Article
Evaluation of SARS-CoV-2 Spike S1 Protein Response on PI3K-Mediated IL-8 ReleaseCommunication Published on 2021-05-182022-10-30 Journal: Medical Sciences [Category] COVID-19, SARS, [키워드] Activation acute respiratory syndrome caused cellular cellular response Comorbidity COVID-19 Critical cytokine determine downstream effort Extensive global pandemic IL-8 interleukin-8 mechanism mitigate modulate mortalities Novel coronavirus overcome Pathogenesis pathway PI3K PI3K signaling potential therapeutic target Protein Release response S1 protein SARS-CoV-2 SARS-COV-2 infection Signaling signaling pathway spike the SARS-CoV-2 the Spike Therapeutic approach while [DOI] 10.3390/medsci9020030 PMC 바로가기 [Article Type] Communication