On virus and nanomaterials – Lessons learned from the innate immune system – ACE activation in the invertebrate model Enchytraeus crypticus바이러스 및 나노물질에 관하여 - 선천적 면역계에서 배운 교훈 - 무척추동물 모델 Enchytraeus crypticus에서 ACE 활성화Article Published on 2022-08-152022-09-11 Journal: Journal of hazardous materials [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE ACE gene ACE2 Activation angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 caused Cell Community Conserved mechanisms Corona Corona virus COVID-19 current database develop down-regulation enzyme experiment expression fold functional immune immune system Inflammatory Innate innate immune response innate immune system invertebrate invertebrates knowledge lesson mechanism Nanomaterial nanomaterials Other receptor Research respiratory responses SARS-CoV-2 Severe acute respiratory syndrome Spike proteins stress condition stress conditions stress response Support the spike protein therapy threat Threats Total transfer triggering vertebrates virus [DOI] 10.1016/j.jhazmat.2022.129173 PMC 바로가기 [Article Type] Article
Tuaimenal A, a Meroterpene from the Irish Deep-Sea Soft Coral Duva florida, Displays Inhibition of the SARS-CoV-2 3CLpro Enzyme아일랜드 심해 연성 산호 Duva florida의 메로테르펜인 Tuaimenal A, SARS-CoV-2 3CLpro 효소 억제 표시Review Published on 2022-05-272022-09-11 Journal: Journal of natural products [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro Bioactivity biochemical assay carbon Cold collected Continental margin Coral display docking experiment exploration human disease in silico inhibit inhibition invertebrate margin Meroterpene metabolome protease representing SARS-CoV-2 Soft the SARS-CoV-2 was determined water [DOI] 10.1021/acs.jnatprod.2c00054 PMC 바로가기 [Article Type] Review
Characterization, in-silico, and in-vitro study of a new steroid derivative from Ophiocoma dentata as a potential treatment for COVID-19 Research Published on 2022-04-072022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 임상, 치료법, 치료제, [키워드] Anti-inflammatory anti-inflammatory activity anti-inflammatory properties antiviral drug characterization component computer Concentration conducted COVID-19 curative demonstrated Efficacy evaluate exhibited fibroblast cells IC50 in-silico In-vitro inhibitor invertebrate investigation molecular docking plaque Potential treatment Red reduction SARS-CoV2 Standard Toxicity Virtual screening [DOI] 10.1038/s41598-022-09809-2 [Article Type] Research
The transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegansArticle Published on 2022-01-102022-10-04 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, 치료제, [키워드] Activation Caenorhabditis Caenorhabditis elegan Control Defense downstream elegan ENCODE expressed function fungal pathogens Gene Expression Host Host transcriptional response hosts immune response induce infect Infection Infectious diseases Innate immunity intestinal intestinal cells intestine invertebrate less molecular Molecular biology nuclei pathogen promote Protective Protein regulatory pathways required resistance to infection RNA virus subset transcription factor Trigger virus [DOI] 10.1038/s41467-021-27621-w PMC 바로가기 [Article Type] Article
The Curious Case of Earthworms and COVID-19Perspective Published on 2021-10-142022-10-28 Journal: Biology [Category] COVID-19, [키워드] activate Anti-viral Bacteria can be used Charles Darwin coronavirus 2 COVID-19 COVID-19 vaccines Earthworm elicited example Gene Expression Genome human SARS-CoV-2 immune immune system Immunity in vivo information invertebrate kill lysenin mechanism mechanisms Nanoparticles non-toxic organism potential risk Protein Proteins respiratory SARS-CoV-2 Scientific community shown simple therapeutic Toxicity unique virus viruses worm [DOI] 10.3390/biology10101043 PMC 바로가기 [Article Type] Perspective
Annelid genomes: Enchytraeus crypticus , a soil model for the innate (and primed) immune systemArticle Published on 2021-09-062022-10-29 Journal: Lab Animal [Category] COVID-19, MERS, SARS, [키워드] ACE ACE2 Annelid Annelida antibiotic Bioscience cell entry Combination coronavirus SARS-CoV-2 distribution elements Environmental sciences enzyme gene families Genes Genome Genomics highlight homolog horizontal gene identify Illumina immune system innate immune system Innate immunity Interaction invertebrate involved nuclear P450 platform Protein reference genome Sequencing Significant Stress transfer worm [DOI] 10.1038/s41684-021-00831-x PMC 바로가기 [Article Type] Article
Utilizing comparative models in biomedical researchResearch article Published on 2021-08-012022-10-05 Journal: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology [Category] 비임상, [키워드] biochemical Biochemistry Biomedical research Caenorhabditis elegans Community Comparative Danio developmental disease Drosophila melanogaster example invertebrate issue knowledge less mechanisms pathology physiological Physiology unique vertebrates while Xenopus [DOI] 10.1016/j.cbpb.2021.110593 [Article Type] Research article
In Silico Mining of Terpenes from Red-Sea Invertebrates for SARS-CoV-2 Main Protease (M pro ) InhibitorsArticle Published on 2021-04-052022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome addition analyses antiviral medication BCL2L1 binding binding affinity binding energy biochemical component coronavirus COVID-19 COVID-19 pandemic cytokine death demonstrated Diseases Drug discovery ecosystem enrichment analysis greater Human immunodeficiency virus identify IL2 in silico in vitro in vivo infections inhibitor inhibitors Interaction interactions invertebrate M pro marine natural products metabolite molecular molecular docking molecular dynamics performed protease Protease inhibitor reported SARS-CoV-2 SARS-CoV-2 main protease screened Signaling stability terpene the SARS-CoV-2 treat Virtual drug screening [DOI] 10.3390/molecules26072082 PMC 바로가기 [Article Type] Article
Exome-wide association study reveals largely distinct gene sets underlying specific resistance to dengue virus types 1 and 3 in Aedes aegypti엑솜 전체의 연관성 연구는 이집트숲모기(Aedes aegypti)에서 뎅기열 바이러스 유형 1 및 3에 대한 특이적 내성을 기본으로 하는 크게 구별되는 유전자 세트를 보여줍니다Research Article Published on 2020-05-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adjusted Aede allelic variant allelic variants association ATP average binding activity compatibility Dengue dengue virus DENV-1 DENV-3 Exome exomes exposure to Frequency Gabon Genes Genetic genetic architecture genetic marker Genetic polymorphism genetic polymorphisms Genetic variation Genome group Host host gene host genes host-pathogen interactions hosts identify indicate Infection Interaction invertebrate invertebrates investigated involved mechanism Mosquito natural population p values pathogen pathogen genotype pathogen-specific Pathogens phenotype phenotypic polymorphism Region reveal sequenced significantly single-nucleotide single-nucleotide polymorphism SNP specific resistance specificity statistical strain Strains sulfur susceptible the mosquito transmembrane variant Variation with infection Zinc zinc ion [DOI] 10.1371/journal.pgen.1008794 PMC 바로가기 [Article Type] Research Article
TRPV4: A Physio and Pathophysiologically Significant Ion ChannelReview Published on 2020-05-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] animal model channel clinical trial Consequences disease dysfunction Evidence highlight Human invertebrate Ion pathophysiological physiological Potential Protein receive Significant Structure therapeutic target Transient TRP TRP channels TRPV1 TRPV4 variety vertebrates [DOI] 10.3390/ijms21113837 PMC 바로가기 [Article Type] Review