Does diabetes risk after SARS-CoV-2 infection depend on the viral variant?Article Published on 2022-09-012022-11-16 Journal: Diabetes research and clinical practice [Category] SARS, 변종, [키워드] Care causal link COVID-19 diabete diabetes distinguishing Effect elevated Evolution exacerbate increased risk individual Infection islets new SARS-CoV-2 no risk public health crisis risk SARS-CoV-2 SARS-COV-2 infection variant with infection [DOI] 10.1016/j.diabres.2022.110054 PMC 바로가기
Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis차등 유전자 발현 패턴 분석에 의한 COVID-19와 당뇨병 사이의 일반적인 병원성 과정 발견Case Study Published on 2021-11-172022-09-01 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] analyses Analysis biological processe biological processes blood gene expression caused characterized Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient dataset DEGs diabete diabetes Diabetes Mellitus Differential gene expression differentially expressed gene downregulated dysregulated followed by functional Functional assessment Gene ontology GO term identify implicated Increased Infectious disease involved islets modulated molecular pathways mononuclear cell mononuclear cells Ontology Organoid pancrea pancreas pathway Pathways patients with diabete PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells prediction RELA SARS-CoV-2 severity of COVID-19 T1D T2D transcription factor transcription factors transcriptional transcriptional signatures transcriptomic Treatment Type 1 diabetes type 2 diabete type 2 diabetes upregulated upregulation whole-genome [DOI] 10.1093/bib/bbab262 PMC 바로가기 [Article Type] Case Study
Interaction of Severe Acute Respiratory Syndrome Coronavirus 2 and Diabetes중증급성호흡기증후군 코로나바이러스 2와 당뇨병의 상호작용Review Published on 2021-10-062022-09-11 Journal: Frontiers in Endocrinology [Category] MERS, 치료제, [키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus aggravate angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal models Anti-inflammatory binding cause cells coronavirus coronavirus 2 COVID – 19 damage diabete diabetes diabetes - quality of life Diabetic diabetic patient diabetic patients dipeptidyl peptidase DPP4 drug Effect Epidemic expression focus furin glucagon glucagon-like peptide glucagon-like peptide 1 identify immune disorder immunocellular response influence influences inhibitor insulin insulin resistance involved islets lung lung dysfunction mechanism metformin mTOR mTOR signaling OAD OADs organs outcome pancreatic Patient peptidase peptide PPARγ Rapamycin receptor respiratory risk SARS-CoV-2 SARS-CoV-2 (2019-nCoV) SARS-COV-2 infection SARS-CoV-2 infections severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown signaling pathway Spread suppression Treatment Trigger type 2 diabete Type 2 diabetes mellitus underlying disease underlying diseases [DOI] 10.3389/fendo.2021.731974 PMC 바로가기 [Article Type] Review
ACE2 function in the pancreatic islet: Implications for relationship between SARS‐CoV‐2 and diabetesReview Article Published on 2021-10-022022-10-27 Journal: Acta physiologica (Oxford, England) [Category] COVID-19, [키워드] ACE2 addition angiotensin‐converting enzyme 2 Beta cells Cell cell physiology cells COVID‐19 patient COVID‐19 diabete diabetes dissect Effect Endocrine enzyme expressed expression Factor Glucose glucose homoeostasis homoeostasis host cells in vitro infect Injury insulin Insulin sensitivity islet islets lung metabolism molecular molecular mechanism pancrea pancreatic pancreatic islet Pathogenesis pathophysiology Protein required SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected secretion suggested susceptibility therapeutic intervention triggered [DOI] 10.1111/apha.13733 PMC 바로가기 [Article Type] Review Article
ACE2 function in the pancreatic islet: Implications for relationship between SARS‐CoV‐2 and diabetesReview Article Published on 2021-10-022022-10-27 Journal: Acta physiologica (Oxford, England) [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] ACE2 addition angiotensin‐converting enzyme 2 Beta cells Cell cell physiology cells COVID‐19 patient COVID‐19 diabete diabetes dissect Effect Endocrine enzyme expressed expression Factor Glucose glucose homoeostasis homoeostasis host cells in vitro infect Injury insulin Insulin sensitivity islet islets lung metabolism molecular molecular mechanism pancrea pancreatic pancreatic islet Pathogenesis pathophysiology Protein required SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected secretion suggested susceptibility therapeutic intervention triggered [DOI] 10.1111/apha.13733 PMC 바로가기 [Article Type] Review Article
Deleterious Effects of SARS-CoV-2 Infection on Human Pancreatic Cells인간 췌장 세포에 대한 SARS-CoV-2 감염의 해로운 영향Cellular and Infection Microbiology Published on 2021-06-232022-09-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 진단, [키워드] ACE2 acinar cells Affect antiviral drug cause caused Cell cells cellular phenotypes characterized composed coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patients Culture CXCL12 cytokine deaths deleterious effect ductal cells Effect Endocrine Evidence Express expression Genes Hospitalization Human infect Infection Inflammatory response involved iPSCs islets majority molecular pancrea pancreas pancreatic Pancreatitis platform Post-mortem presenting receptor respiratory respiratory tract SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Stress the SARS-CoV-2 These cells tissue transcriptome analysis transmitted virus virus entry with COVID-19 [DOI] 10.3389/fcimb.2021.678482 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Islet organoid as a promising model for diabetesReview Published on 2021-03-102022-10-29 Journal: Protein & Cell [Category] COVID-19, COVID19(2023년), SARS, [키워드] abnormality autologous cellular contributing to diabete diabetes disease Disease model Drug screening effort functional heterogeneity immature IMPROVE in vitro Infection involved islet islet organoid islet transplantation islets lack mechanism Morphological organ Organoid organoids pancreatic β cell pancreatic islet pathological conditions pluripotent/adult stem cell regenerative SARS-CoV-2 STEM therapy virus [DOI] 10.1007/s13238-021-00831-0 PMC 바로가기 [Article Type] Review
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas Research Published on 2021-02-032022-10-05 Journal: Nature metabolism [Category] 치료기술, [키워드] acute respiratory syndrome Cell cells changes clinical contribute coronavirus coronavirus disease COVID-19 diabete dysregulation Endocrine Ex vivo experimental evidence Express functional Glucose Granule homoeostasis identify impair in vivo infect Infection insulin investigated islet islets marker Morphological pancrea pancreatic Patient patients with COVID-19 positive postmortem examinations Protein Proteins reduced replicate SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid secretion tissue transcriptional viral entry β-cell [DOI] 10.1038/s42255-021-00347-1 [Article Type] Research
Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic DonorsArticle Published on 2020-08-072022-10-28 Journal: Biology [Category] COVID-19, [키워드] ACE2 ACE2 expression ADAM17 adipose age binding BMI cells correlated COVID-19 diabete diabetes Diabetic diabetics Donor donors Endocrine entry of SARS-CoV-2 explain Express expression expression data expression level expression pattern female Gender Human human islets islet islets Microarray not affected occur pancreatic pancreatic islet pancreatic islets patients priming profile promote receptor required Revealed RNA-Seq RNA-sequencing S1 protein SARS-CoV-2 severity of COVID-19 significantly higher significantly increased statistically Symptom T2D the S protein thought tissue TMPRSS2 TMPRSS2 expression Variation viral spike [DOI] 10.3390/biology9080215 PMC 바로가기 [Article Type] Article
Characterization of porcine endogenous retrovirus expression in neonatal and adult pig pancreatic isletsArticle Published on 2017-07-012023-06-21 Journal: Xenotransplantation [Category] 조류인플루엔자, [키워드] expression islets neonatal pigs pancreas PIGS porcine endogenous retrovirus (PERV) xenotransplantation [DOI] 10.1111/xen.12311