Carbon dioxide and MAPK signalling: towards therapy for inflammationarticle Published on 2023-10-102024-09-05 Journal: Cell Communication and Signaling : CCS [Category] update2024, [키워드] ERK1/2 hypercapnia hypercarbia Hypocapnia JNK p38 [DOI] 10.1186/s12964-023-01306-x PMC 바로가기 [Article Type] article
ALK-JNK signaling promotes NLRP3 inflammasome activation and pyroptosis via NEK7 during Streptococcus pneumoniae infectionarticle Published on 2023-05-312024-09-01 Journal: Molecular Immunology [Category] 폐렴구균 감염증, [키워드] ALK JNK NEK7 NLRP3 inflammasome pyroptosis Streptococcus pneumoniae [Article Type] article
Vitamin D modulates systemic inflammation in patients with severe COVID-19Research article Published on 2022-10-012022-10-05 Journal: Life sciences [Category] 바이오마커, 임상, 치료기술, [키워드] AKT Anti-inflammatory effects attenuate Blood blood sample C-reactive protein clinical setting condition COVID-19 COVID-19 infection D-dimer ELISA evaluate expression Hyperinflammatory ICU IL-17 IL-1β IL-6 immune response immunomodulatory in vitro Inflammatory response intensive care investigated JNK marker material modulate Nasopharyngeal swab pathway Patient patients PBMC Proinflammatory cytokine reveal Serum level severe COVID-19 severity signaling pathway Significance STAT3 stimulated systemic inflammation treated treated patient Treatment untreated patient Vitamin D was used western blotting with COVID-19 [DOI] 10.1016/j.lfs.2022.120909 [Article Type] Research article
Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells스쿠텔라레인은 RAW264.7 세포에서 NF-κB/MAPK 신호 전달 경로를 통해 LPS 유도 염증을 억제합니다Article Published on 2022-06-122022-09-11 Journal: Molecules [Category] 유전자 메커니즘, [키워드] addition Anti-inflammatory can be used Cell cells Chinese composed Compound COVID-19 Cyclooxygenase cytokine Cytokines determine diploid endotoxin ERK expression Extracellular family Gram-negative bacteria Helicase IL-1β Immune cell immune cells immune system Inflammation Inflammatory inflammatory disorder inflammatory disorders inhibit interleukin interleukin-1β involved IκBα JNK kinases lipopolysaccharide LPS LPS-induced inflammation MAPK mechanism mitogen NF-kB NF-кB nitric oxide nitric oxide synthase no effect nuclear outer membrane p65 pathway Pathways pro-inflammatory mediators proinflammatory mediators protein kinase required SARS Coronavirus SCU scutellarein scutellarein (SCU). secretion shown stimulate stimulated TNF-α Topic treat Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α was reduced western blot [DOI] 10.3390/molecules27123782 PMC 바로가기 [Article Type] Article
Novel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in RussiaCOVID-19 관련 사망률의 새로운 예후 결정 요인: 러시아의 중증 환자에 대한 파일럿 연구Research Article Published on 2022-02-252022-09-12 Journal: PLoS ONE [Category] MERS, 진단, [키워드] apoptotic approach CD14 CD14+ Characteristics Cohort Course COVID-19 COVID-19 pandemic COVID-19-related death CT scan dead determinant determinants diagnostics elevated healthcare high risk IL-17 increased expression JNK Laboratory lymphocyte lymphocyte counts Lymphocytes Monocytes Mortality Non-invasive novel outcome Patient PBMCs pilot study predictor prognostic Prognostic factors Russia Serum level serum levels Severe case Stratification Treatment Trial [DOI] 10.1371/journal.pone.0264072 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Infected Pediatric Cerebral Cortical Neurons: Transcriptomic Analysis and Potential Role of Toll-like Receptors in PathogenesisSARS-CoV-2에 감염된 소아 대뇌 피질 뉴런: 전사체 분석 및 병인에서 유료 유사 수용체의 잠재적 역할Article Published on 2021-07-282022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] ACE2 caspase caspase 8 cells cerebral changes in chemokine chemokines children cortical COVID-19 neurological symptom COVID-19 neurological symptoms deregulation downregulated downregulation downstream ERK expression genes encoding human neuronal cells IKKε increase in increased expression infect infected with SARS-CoV-2 IRF3 JNK mechanism medium nervous system Neurological involvement Neurological symptoms Neuron neuronal next generation sequencing NF-κB Nod-like receptors not express Pathogenesis Pattern recognition pattern recognition receptor pediatric Potential receptor receptors replicate responsible role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins scavenger receptors Sequencing Signaling TLR TLR1 TLR4 TLR6 TLRs TMPRSS2 Toll-like receptor Toll-like receptors TRAF3 transcriptomic analysis transcriptomic profile upregulated upregulation Viral Viral RNA western blot [DOI] 10.3390/ijms22158059 PMC 바로가기 [Article Type] Article
In Vitro Antiviral Activities of Salinomycin on Porcine Epidemic Diarrhea VirusArticle Published on 2021-03-302022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Activation activity ameliorated antivirals can be used catastrophic coronavirus develop dose-dependent manner effective vaccine epidemic diarrhea Impact increase in independent Infection inhibit inhibited JNK lack MAPK MAPK pathway oxidative Particles pathway PEDV reactive Replication ROS Salinomycin signaling pathway significantly suppresse therapeutic option Vero Cell Vero cells viral-induced virus [DOI] 10.3390/v13040580 PMC 바로가기 [Article Type] Article
Administration of zoledronic acid alleviates osteoporosis in HIV patients by suppressing osteoclastogenesis via regulating RANKL expressionzoledronic acid 투여는 RANKL 발현 조절을 통해 파골세포 형성을 억제함으로써 HIV 환자의 골다공증 완화Research Article Published on 2021-02-262022-09-06 Journal: Molecular Medicine [Category] Communicable Disease, [키워드] 3′ UTR activated activating administration alleviate binding carried demonstrated down-regulated ELISA evaluate expression expression of gene HIV HIV patient HIV patients inhibitory effect Inhibitory effects involved JNK luciferase Luciferase assays mechanism miR-101 miR-145 miRNA modulating osteocalcin osteoclast Osteoclastogenesis Osteoporosis Pathways patients PRKACB quantitative real-time PCR RANKL Real-time PCR restored Result serum signaling pathway signaling pathways significantly Smad3 subject suppressed tenofovir treated Treatment was performed was used western blot Zoledronic acid [DOI] 10.1186/s10020-021-00276-5 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 spike protein S1 subunit induces pro-inflammatory responses via toll-like receptor 4 signaling in murine and human macrophagesResearch Article Published on 2021-02-022022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] abrogate activate activated Activation acute respiratory syndrome caused coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine develop Effect examined excessive inflammation experiment exposure to human macrophage human macrophages induce Infectious disease Inflammation Inflammatory inhibitor intracellular signaling involved JNK Macrophage macrophages mechanism Mortality multiple organ failure murine N-terminal neutralizing antibody NF-κB nuclear Pathways Patient pro-inflammatory cytokine pro-inflammatory mediator pro-inflammatory response produced Protein receptor S1 subunit SARS-CoV-2 SARS-CoV-2 spike protein selective severe complication severity Signaling signaling pathways spike Spike protein Spread suggested suppressed the disease THP-1 TLR2 TLR4 toll-like receptor 4 [DOI] 10.1016/j.heliyon.2021.e06187 PMC 바로가기 [Article Type] Research Article
Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2SARS-CoV-2에 대한 숙주 세포의 전사 반응을 기반으로 COVID-19에 대한 약물 용도 변경을 위한 전산 분석Research Article Published on 2021-01-072022-09-10 Journal: BMC Medical Informatics and Decision Making [Category] 신약개발, 유전자 메커니즘, 치료제, [키워드] activated addition affected Analysis approach caused clinical trials coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 treatment Critical CXCR6 Data analysis death rate Dexamethasone drug drug-target effective effective drug effective drugs epithelial cell epithelial cells ERK evaluated facilitate Gene Expression high mortality rate host cell host cells human lung human lung epithelial cells identify immune Infection Integrative analysis involved IRF7 Jak-STAT JNK life cycle MAPK molecular MYD88 NFkB Ontology pandemic pathway Pathways receiving reduce reported Repurposed drug Repurposed drugs resources respiratory Respiratory Support Result SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling signaling pathway signaling pathways significantly STAT therapy transcriptional response Treatment treatments for COVID-19 Vaccine [DOI] 10.1186/s12911-020-01373-x PMC 바로가기 [Article Type] Research Article