Remdesivir does not affect mitochondrial DNA copy number or deletion mutation frequency in aged male rats: A short reportArticle Published on 2022-10-262022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] Affect age Brain clinical samples coronavirus determine digital PCR DNA Effect Frequency Future hearts Hypothesis individuals inhibiting kidneys liver majority male mammals mitochondrial Mutation no effect not affect Older patients with moderate Remdesivir RNA-directed RNA polymerases rodents SARS-CoV-2 Skeletal muscle Support therapy tissue treated Treatment Viral RNA [DOI] 10.1371/journal.pone.0271850 PMC 바로가기
COVID-19 Pathology in the Lung, Kidney, Heart and Brain: The Different Roles of T-Cells, Macrophages, and MicrothrombosisArticle Published on 2022-10-042022-11-15 Journal: Cells [Category] COVID19(2023년), SARS, 진단, [키워드] activated activated macrophages Activation age antibody Autopsy B-lymphocytes Brain change characteristic Clinical course controls COVID-19 COVID-19 case COVID-19 pathology elderly exhibited feature foci greater heart hearts highest Hyperactivation Inflammation Inflammatory kidney kidneys lung lung; Lymphocytes microglial Microthrombosis Neuropathology nine other tissue pathology pathophysiology PCR Platelets predominant role SARS-CoV-2 significantly significantly higher T-lymphocyte T-lymphocytes the disease tissue tissues viral antigens viral replication Viral RNA were used [DOI] 10.3390/cells11193124 PMC 바로가기
Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19Research article Published on 2022-10-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory distress Affect Algorithm Analysis antiviral therapy Brain causes clinical study Col1a1 collagen Comorbidities Complication complications component Control coronavirus COVID-19 COVID-19 patients develop diagnostic drug drug repositioning FDA approved drug Genetic help immune system independent Infection Inflammation Inflammatory response Influenza involved kidneys Lungs machine learning methodology offer other organ pathway Pathways Patient performed principal Regulation response responsible Result reveal RSV SARS-CoV-2 SARS-COV-2 infection severity Side effect Side effects Small scale genetic signature susceptibility syndrome the disease the interferon Transcriptome transcriptomic transcriptomic analysis transcriptomic data virus replication [DOI] 10.1016/j.compbiomed.2022.106029 [Article Type] Research article
Fatal Form of COVID-19 in a Young Male Bodybuilder Anabolic Steroid Using: The First Autopsied CaseArticle Published on 2022-09-292022-11-15 Journal: Medicina [Category] SARS, 진단, [키워드] ACE-2 receptor anabolic anabolic androgenic steroids androgenic steroid atherosclerotic plaques Autopsy COVID-19 death Diffuse alveolar damage Endothelitis form Genetic Genetic predisposition histopathological HLA allele immune system Infection kidneys liver lung male microthrombi Myocardial infarction Myocardium organs pancreas Patient positive Pulmonary edema risk risk factor SARS-CoV-2 SARS-CoV-2 RT-PCR test spleen steroid Testosterone Thromboembolism tissue [DOI] 10.3390/medicina58101373 PMC 바로가기
Organ transplantation using COVID-19-positive deceased donorsArticle Published on 2022-09-012022-10-06 Journal: American journal of transplantation : official jou [Category] 진단, [키워드] Affect clinical research/practice coronavirus COVID-19 COVID-19 infection COVID-19 negative COVID-19 pandemic COVID-19 test COVID-19 testing database death Deceased Donor donors donors and donation: deceased feasible groups hearts Infection infection and infectious agents-viral: SARS-CoV-2/COVID-19 Infectious disease information kidneys livers Lungs median time network not affect opinion OPTN organ organ transplantation Patient patient survival positive positive COVID-19 receiving recipient solid organ solid organ transplant solid organ transplantation stratified survival United Network for Organ Sharing (UNOS) were assessed while with COVID-19 [DOI] 10.1111/ajt.17145 PMC 바로가기 [Article Type] Article
Gene Network Analysis of the Transcriptome Impact of SARS-CoV-2 Interacting MicroRNAs in COVID-19 DiseaseCOVID-19 질병에서 SARS-CoV-2 상호작용 MicroRNA의 전사체 영향에 대한 유전자 네트워크 분석Review Published on 2022-08-172022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] affected Analysis biochemical biological processes Cell cell cycle cell surface receptor changes characterized COVID-19 COVID-19 disease cytokine death DEGs differentially expressed differentially expressed gene Differentially expressed genes downregulated exploratory FIVE functional enrichment Functional enrichment analysis Gene Expression gene network Health Organization heart Impact involved kidneys list lung Lymph node microRNA MicroRNAs mitochondrial mitotic mitotic cell modulation molecular Multiorgan multiorgan disease network network analysis pathological mechanism Pathways Perspective predicted provide reported SARS-CoV-2 SARS-CoV-2 virus signaling pathway submitted surface receptor target tissue tissues transcriptomes translated upregulated WHO with COVID-19 World Health Organization [DOI] 10.3390/ijms23169239 PMC 바로가기 [Article Type] Review
Solid organ transplantation from donors with recent or current SARS-CoV-2 infection: A systematic review최근 또는 현재 SARS-CoV-2 감염이 있는 기증자의 고형 장기 이식: 체계적인 검토Review Published on 2022-08-012022-09-11 Journal: Anaesthesia, critical care & pain medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] anti-SARS-CoV-2 titer Cochrane COVID-19 Study Register complications COVID-19 COVID-19 symptoms cycle database died Donor donors dysfunction evaluate for inclusion heart Hospital stay IQR kidney kidneys liver lung median Mortality occurred organ Organ donation organ transplantation organs outcome Patient patients died positive recipient recipients rejection risk of transmission Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 viral Septic shock solid organ solid organ transplantation SOT Symptom symptomatic systematic review threshold Transmission Transplant two patients viral replication Viral transmission was performed Web of Science [DOI] 10.1016/j.accpm.2022.101098 PMC 바로가기 [Article Type] Review
Systematic lupus erythematous patients following COVID-19 vaccination: Its flares up and precautionsShort communication Published on 2022-08-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 치료제, [키워드] adenovirus vaccine adverse effect adverse effects antibody antiviral response Autoimmune adverse effects Autoimmune disease boost caused Central nervous system clinical Comorbidities Complication COVID-19 COVID-19 vaccination COVID-19 vaccine cytokine diagnose Disease activity dsDNA erythematous immune Inflammatory interfere interferons intrinsic joints kidneys likelihood Lupus flare-up majority medications mRNA mRNA vaccination mRNA vaccine multiple organs notable organ damage pathophysiology Patient Precaution required Rheumatic diseases SARS-CoV-2 SARS-CoV-2 vaccine serological shown significantly SLE SLE patient Spread Symptom systemic systemic lupus erythematosus type I interferon Vaccinations with COVID-19 [DOI] 10.1016/j.amsu.2022.104282 [Article Type] Short communication
Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice심각한 COVID-19 치료를 위해 인간 miRNA를 표적으로 하는 나노 올리고머는 마우스에서 안전하고 독성이 없습니다Article Published on 2022-07-112022-09-11 Journal: ACS Biomaterials Science & Engineering [Category] COVID19(2023년), SARS, 치료제, [키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antisense therapy Antiviral strategies Antiviral treatment bind biodistribution biodistribution study body weight Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect fatality Histopathology Host Host immune response Human human cell human cells immune immunogenicity Infection Inflammation intranasal intraperitoneal intravenous Intravenous administration kidney kidneys liver Lungs mice microRNA miRNA MOST mouse model organ organs pandemic parameters produced question response Safe Safety SARS-CoV-2 serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe case severe cases spleen targeting tested Urine with infection [DOI] 10.1021/acsbiomaterials.2c00510 PMC 바로가기 [Article Type] Article
Safety considerations of chloroquine in the treatment of patients with diabetes and COVID-19Research article Published on 2022-07-012022-10-05 Journal: Chemico-biological interactions [Category] COVID19(2023년), SARS, 신약개발, 치료법, 치료제, [키워드] adverse effect Cardiotoxicity caused changed Chloroquine Chloroquine phosphate coronavirus disease COVID-19 death diabetes Diabetic dosage dose Drug safety effective Electrocardiograms elevated hepatic enzyme High dose High-dose high-dose group humans IL-1β IL-6 levels increased risk intervals kidneys leukocyte liver observation Ocular toxicity Patient patients with diabete produced Protein QTc regimen Safety serum Severe case significantly spleen T2D total mortality treat Treatment type 2 diabete underlying disease [DOI] 10.1016/j.cbi.2022.109954 [Article Type] Research article