Role of narL gene in the pathogenesis of Salmonella Typhimuriumarticle Published on 2024-05-312024-09-01 Journal: Journal of Basic Microbiology [Category] 살모넬라증, [키워드] biofilm invasion and colonization knockout motility Salmonella [Article Type] article
Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with influenza A virusGenome Editing Original Research Published on 2024-05-312024-09-05 Journal: Frontiers in Genome Editing [Category] update2024, [키워드] influenza A knockout Proinflammatory response RNAscope somatic cell nuclear transfer swine TMPRSS2 gene [DOI] 10.3389/fgeed.2023.1320180 PMC 바로가기 [Article Type] Genome Editing Original Research
Generation of a VeroE6 Pgp gene knock out cell line and its use in SARS-CoV-2 antiviral studyArticle Published on 2022-12-012023-07-10 Journal: Antiviral Research [Category] COVID19(2023년), [키워드] knockout Nirmatrelvir PGP SARS-CoV-2 Vero cells. [DOI] 10.1016/j.antiviral.2022.105429 PMC 바로가기
Poliovirus nonpermissive CD155 knockout cells derived from RD cell line for handling poliovirus potentially infectious materials in virology laboratoriesarticle Published on 2022-10-312024-09-01 Journal: Journal of medical virology [Category] 폴리오, [키워드] CRISPR knockout NPEV poliovirus containment RD cells WHO-GAP III [Article Type] article
Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19Article Published on 2022-09-062022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단, [키워드] alarmin antiviral response approach binding blood leukocyte characterized COVID-19 COVID-19 pathogenesis differentially expressed down-regulation driver expression humans Immunity immunopathology JAK-STAT pathway knockout lincRNA lncRNA long noncoding RNA LUCAT1 monocyte Monocytes naïve NF-κB NF-κB-dependent gene noncoding RNA nuclear promote promoter pseudogene PU.1 Release remained RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Single-cell RNA sequencing single-cell RNA-seq Stat1 suggested systemic immune response target Transcription transcription factor transcription factors transcriptional transgene viral infection [DOI] 10.1073/pnas.2120680119 PMC 바로가기
SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl – accumulation in respiratory epitheliumSARS-CoV-2 뉴클레오캡시드 단백질은 단백질-단백질 상호작용 매개 세포내 Cl-호흡 상피에서의 축적을 통해 과염증을 유발합니다Article Published on 2022-07-272022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 신약개발, 치료법, [키워드] abrogated Airway inflammation CAMP cell lines cells CFTR Concentration COVID-19 cystic fibrosis Cytokine storms Defense demonstrated depleting downregulated elicit epithelial epithelial cell epithelial cells expression fibrosis glucocorticoid Host host defense human airway epithelial hyperinflammation immune response immune responses Inflammatory response Inflammatory responses inhibition inhibitor Intracellular knockout microRNA modulating murine model murine models N protein pathogen phosphodiesterase Phosphorylation promoted Protein pulmonary inflammation raised reducing regulated respiratory epithelium resulting robust Rolipram SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid second messenger selective serum SGK1 signaling pathway Smad3 structural protein suggested sustained targeting therapeutic strategy transmembrane Trigger upregulation [DOI] 10.1038/s41392-022-01048-1 PMC 바로가기 [Article Type] Article
Endogenous opiates and behavior: 2020Review article Published on 2022-05-012022-10-05 Journal: Peptides [Category] 비임상, [키워드] Gly-ol(5)-enkephalin Nme(4) Acetylcholine AChAcetylcholine acid-sensing ion channel ACLanterior cruciate ligament ACTHadrenocorticotrophic hormone adenosine monophosphate adrenocorticotrophic hormone agonist alcohol AMPadenosine monophosphate antagonists anterior cruciate ligament ARCarcuate nucleus of hypothalamus arcuate nucleus of hypothalamus article ASICacid-sensing ion channel baso-lateral amygdala BDNFbrain-derived neurotrophic factor bed nucleus of the stria terminalis BENDbeta-endorphin beta-endorphin beta-funaltrexamine BFNAbeta-funaltrexamine BLAbaso-lateral amygdala BMIbody mass index BNSTbed nucleus of the stria terminalis body mass index brain-derived neurotrophic factor Ca(2+)/cAMP responsive element binding protein cannabinoid CBcannabinoid CCIchronic constriction injury CCKcholecystokinin CCRchemokine receptor CFAcomplete Freund’s adjuvant ChATcholine acetyltransferase Chemokine receptor cholecystokinin choline acetyltransferase chronic constriction injury complete Freund’s adjuvant concerning conditioned place preference CPPconditioned place preference CREBCa(2+)/cAMP responsive element binding protein CTAPD-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 D-Ala(2) D-Arg-Phe-Lys-NH2 D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 DAdopamine DALDAD-Arg-Phe-Lys-NH2 DAMGOD-Ala(2) delta opioid receptor Deltdeltorphin deltorphin Dopamine DORdelta opioid receptor dorsal root ganglion DRGdorsal root ganglion DYNDynorphin Dynorphin Effect EGFRepidermal growth factor receptor encephalin endogenous Endoplasmic reticulum Enkencephalin epidermal growth factor receptor ERendoplasmic reticulum ERKextracellular regulated signal kinases extracellular regulated signal kinases G protein-coupled receptor kinase G-protein-coupled receptor GABAgamma-amino butyric acid gamma-amino butyric acid Gastrointestinal genetic manipulation GIGastrointestinal GLPglucagon-like peptide glucagon-like peptide GPCRG-protein-coupled receptor GRKG protein-coupled receptor kinase heat shock proteifn hepatic function HIVhuman immunodeficiency virus Hormones HSPheat shock proteifn Human Human immunodeficiency virus ICUIntensive Care Unit ILInterleukin Immunological response inhibitory postsynaptic current intensive care unit interleukin IPSCinhibitory postsynaptic current JNKJun-N-terminal kinase Jun-N-terminal kinase K(+)potassium kappa opioid receptor kappa opioid receptor gene kisspeptin KNDykisspeptin knockout KOknockout KORkappa opioid receptor lateral magnocellular nucleus of the anterior nidopallium LClocus coeruleus leutinizing hormone LHleutinizing hormone lipopolysaccharide LMANlateral magnocellular nucleus of the anterior nidopallium locus coeruleus long-term depression LPSlipopolysaccharide LTDlong-term depression MAPKmitogen-activated protein kinase MeAmedial nucleus of amygdala medial nucleus of amygdala medial prefrontal cortex memory Menkmet-enkephalin mental illness met-enkephalin mitogen-activated protein kinase molecular MORmu opioid receptor mPFCmedial prefrontal cortex mu opioid receptor mu opioid receptor gene naltrindole NBNInor-binaltorphamine neurologic disorder nitric oxide nitric oxide synthase non-steroidal anti-inflammatory drug NONitric Oxide nor-binaltorphamine NOSnitric oxide synthase NSAIDnon-steroidal anti-inflammatory drug NTInaltrindole OFCorbito-frontal cortex OPRK1kappa opioid receptor gene OPRM1mu opioid receptor gene orbito-frontal cortex ORL-1orphan receptor like receptor orphan receptor like receptor Pain patient controlled analgesia PCApatient controlled analgesia PD-1programmed cell death protein-1 PDYNprodynorphin PENKpre-proenkephalin peptide PFCpre-frontal cortex pharmacological PKCprotein kinase C POFQ/Npro-nociceptin POMCpro-opiomelanocortin Post-traumatic stress disorder Potassium pre-frontal cortex pre-proenkephalin Pregnancy pro-nociceptin pro-opiomelanocortin prodynorphin programmed cell death protein-1 prolonged release protein kinase C PRprolonged release PTSDpost-traumatic stress disorder receptor regulators of G-protein signaling renal Research response RGSregulators of G-protein signaling rostral ventromedial medulla RVMrostral ventromedial medulla Seizure Single nucleotide polymorphism SNLspinal nerve ligation SNPSingle nucleotide polymorphism SNSubstantia nigra spinal nerve ligation Stress substantia nigra TDCStranscranial direct current stimulation Testosterone THtyrosine hydroxylase Tolerance TPtestosterone Transcranial direct current stimulation tyrosine hydroxylase ventral tegmental area VTAventral tegmental area [DOI] 10.1016/j.peptides.2022.170752 [Article Type] Review article
Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone프로게스테론에 의한 SARS-CoV-2를 포함한 바이러스에 대한 선천 면역 반응의 조절Article Published on 2022-04-252022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activate Activation antiviral gene antiviral genes antiviral response Cell downstream Effects Host humoral hypothalamic-pituitary-adrenal axis immunomodulatory induce infectious Inflammatory diseases innate immune response IRF3 knockout metabolism mice modulate opposite PGR phosphorylate progesterone progesterone receptor promote receptor regulated SARS-CoV-2 SARS-CoV-2-infected patient SARS-CoV-2-infected patients severity of COVID-19 SRC Stimulation transcriptional tyrosine viral infection virus [DOI] 10.1038/s41392-022-00981-5 PMC 바로가기 [Article Type] Article
A Phosphoinositide-Binding Protein Acts in the Trafficking Pathway of Hemoglobin in the Malaria Parasite Plasmodium falciparum인산화 이노시톨 결합 단백질이 말라리아 기생충 플라스모디움 팔시파룸에서 헤모글로빈의 이동 경로에서 작용한다.Research Article Published on 2022-01-182024-08-08 Journal: mBio [Category] 말라리아, [키워드] hemoglobin knockout malaria Phosphoinositides vacuoles vesicular trafficking [DOI] 10.1128/mbio.03239-21 PMC 바로가기 [Article Type] Research Article
Exosomes/microvesicles target SARS-CoV-2 via innate and RNA-induced immunity with PIWI-piRNA systemResearch Article Published on 2021-12-032022-10-30 Journal: Life Science Alliance [Category] COVID-19, MERS, SARS, [키워드] adaptive Antiviral antiviral action Antiviral effect antiviral immunity Cell cell type Immunity In vitro infection increased expression Innate immunity knockout PIWIL2 Protein protein translation provided reduce reductions in RNA RNA fragment SARS-CoV-2 SARS-CoV-2 genome shown stem cell Viral RNA [DOI] 10.26508/lsa.202101240 PMC 바로가기 [Article Type] Research Article