Lipoprotein signal peptidase-deficient Streptococcus pneumoniae exhibits impaired Toll-like receptor 2-stimulatory activityarticle Published on 2024-04-302024-09-01 Journal: Microbiology and Immunology [Category] 폐렴구균 감염증, [키워드] lipoprotein lipoprotein signal peptidase Streptococcus pneumoniae Toll‐like receptor 2 triton X‐114 phase separation [Article Type] article
A broad-spectrum pneumococcal vaccine induces mucosal immunity and protects against lethal Streptococcus pneumoniae challengearticle Published on 2023-12-312024-09-01 Journal: Emerging Microbes & Infections [Category] 폐렴구균 감염증, [키워드] lipoprotein mucosal immunity Opsonophagocytosis pneumococcal vaccine Streptococcus pneumoniae [Article Type] article
Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretionOriginal Article Published on 2023-11-302024-09-05 Journal: Mol Metab [Category] update2024, [키워드] Apolipoprotein Lipid absorption Lipid secretion lipoprotein small intestine SURF4 [DOI] 10.1016/j.molmet.2023.101847 PMC 바로가기 [Article Type] Original Article
Anti-Inflammatory Activity of CIGB-258 against Acute Toxicity of Carboxymethyllysine in Paralyzed Zebrafish via Enhancement of High-Density Lipoproteins Stability and FunctionalityArticle Published on 2022-09-042022-11-15 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] activity aggregation ameliorated anti-inflammatory activity Autoimmune disease carboxymethyllysine (CML) cascade caused cholesterol CIGB-258 (Jusvinza) CML co-injection coronavirus disease COVID-19 cytokine Cytokine storm death death rate decrease developmental Efficacy Embryo enhancement exhibited faster ferrous ion Final HDL Heat shock high-density high-density lipoproteins (HDL) highest Hsp60 hyperinflammation infiltration Inflammation Inflammatory inflammatory cells infliximab inhibit injected injection kDa Ligand lipoprotein lowest mechanism neutrophil Pain paralysis Particle peptide plasma protective effect Protein resulting stability Stress Survivability systemic inflammation tissue treated Triglyceride was tested zebrafish [DOI] 10.3390/ijms231710130 PMC 바로가기
Are lipid ratios and triglyceride-glucose index associated with critical care outcomes in COVID-19 patients?지질 비율과 트리글리세리드-글루코스 지수는 COVID-19 환자의 중환자 치료 결과와 관련이 있습니까?Article Published on 2022-08-012022-09-11 Journal: PLoS ONE [Category] 바이오마커, [키워드] adjusted age Analysis biochemical marker biochemical markers BMI carried cholesterol coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 mortality COVID-19 patient Critical care demonstrated evaluate Glucose HDL-C high-density insulin insulin resistance LDL-C Lipid lipoprotein Logistic regression analysis low-density Low-density lipoprotein Mortality multivariate multivariate logistic regression analysis outcome performed predictor Prognosis Regression regression models Research severe coronavirus disease Severe patient severe patients severity Sex significantly higher significantly lower statistically survivor Total cholesterol Triglyceride with COVID-19 [DOI] 10.1371/journal.pone.0272000 PMC 바로가기 [Article Type] Article
The role of lipoprotein(a) in coronavirus disease 2019 (COVID-19) with relation to development of severe acute kidney injury중증 급성 신장 손상의 발병과 관련하여 2019년 코로나바이러스(COVID-19)에서 지단백질(a)의 역할Observational Study Published on 2022-04-012022-09-11 Journal: Journal of Thrombosis and Thrombolysis [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] acute kidney failure Acute kidney injury ADAMTS13 Admission adverse outcome adverse outcomes Biomarkers Coagulopathy Concentration controls coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 illness COVID-19 patient COVID-19 patients creatinine defined disease disease severity elevations fibrinogen IL-6 Inflammation interleukin kidney Kidney failure lipoprotein Lipoprotein(a) observational study outcome Pathogenesis patients with COVID-19 positively correlated prospective observational study prothrombotic serum severity severity of COVID-19 sick significantly thrombosis were measured [DOI] 10.1007/s11239-021-02597-y PMC 바로가기 [Article Type] Observational Study
Diagnostic and Therapeutic Potential for HNP-1, HBD-1 and HBD-4 in Pregnant Women with COVID-19COVID-19에 감염된 임산부에서 HNP-1, HBD-1 및 HBD-4에 대한 진단 및 치료 가능성Article Published on 2022-03-222022-09-11 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] affected Alpha AMPs anti-inflammatory cytokine antimicrobial peptide antimicrobial peptides Beta Biochemistry biological activities characterized Coagulation Confirmed COVID-19 infection COVID-19 COVID-19 infection cytokine cytokine profile Cytokines defensin Defensins deficiency defined ELISA assay evaluated fetus Gene Expression generate help highlight IL-10 IL-2 IL-6 IL-8 immune immune system immunological change increase in Infection innate immune system Interleukins involved Laboratory Laboratory medicine lipoprotein lipoprotein-a mechanism mother peptides Potential Pregnancy pregnant women pro-inflammatory factor pro-inflammatory factors problem problems PROTECT risk factor TGF-β TNF-α virus attacks Vitamin vitamins with COVID-19 [DOI] 10.3390/ijms23073450 PMC 바로가기 [Article Type] Article
Novel Synthetic Lipopeptides as Potential Mucosal Adjuvants Enhanced SARS-CoV-2 rRBD-Induced Immune ResponseSARS-CoV-2 rRBD 유도 면역 반응을 향상시키는 잠재적 점막 보조제로서의 새로운 합성 리포펩티드Article Published on 2022-03-092022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] activity adjuvant adjuvants Affect agonist agonists Bacterial BALF candidate vaccine charged residue COVID-19 vaccine CSK cytotoxicity Effect enhanced evaluated exhibited Figuring IgA IgG immune response immunized in vitro induce investigated lipopeptide lipoprotein mimicking mucosal N-terminal nasal novel OVA peptide Potential promote RBD residue response rRBD SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 rRBD sequence sera serum significantly increased significantly lower Structure Structure-activity relationship suggested Support support vector machine SVM synthetic the SARS-CoV-2 TLR2 Vaccine vaccine adjuvant [DOI] 10.3389/fimmu.2022.833418 PMC 바로가기 [Article Type] Article
Self-Adjuvanting Lipoprotein Conjugate αGalCer-RBD Induces Potent Immunity against SARS-CoV-2 and its Variants of Concern자가 보조 지단백질 접합체 αGalCer-RBD는 SARS-CoV-2 및 우려 변종에 대한 강력한 면역을 유도합니다Article Published on 2022-02-102022-09-11 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 agonist Alpha Antigen approach B.1.1.529 best Beta Cell Cellular responses concern conjugate coronavirus COVID-19 pandemic COVID-19 vaccine cross-neutralization develop domain effective effective vaccine Effective vaccines humoral iNKT lipoprotein Liposome natural killer neutralization omicron potent Protein RBD Receptor-binding domain respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly Spike protein subunit vaccines T cell the RBD Vaccine Vaccines variant variants of concern Viral viral spike protein [DOI] 10.1021/acs.jmedchem.1c02000 PMC 바로가기 [Article Type] Article
Anti-SARS-CoV-2 mRNA vaccines as inducers of humoral response against apolipoprotein A-1?Apolipoprotein A-1에 대한 체액 반응의 유도제로서의 Anti-SARS-CoV-2 mRNA 백신?Article Published on 2022-02-012022-09-12 Journal: European Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] AAA1 Affect anti-SARS-CoV-2 anti-SARS-CoV-2 mRNA vaccines anti-SARS-CoV-2 vaccine apolipoprotein A-1 association autoantibodies Autoimmune Autoimmune response baseline Biomarker collected components COVID-19 density first vaccination fraction healthy control healthy controls humoral IgG IgG level IgG response immunoassays individual individuals induce inducer injection lipoprotein Local median mRNA vaccine mRNA-based observé outcomes Patient patients Population populations Prognosis Protein protocol raised recipient retrieved rheumatoid arthritis SARS-CoV-2 second vaccination serology shown significant increase Symptom systemic translate vaccination were measured were recorded [DOI] 10.1111/eci.13713 PMC 바로가기 [Article Type] Article