Systematic comparison of ranking aggregation methods for gene lists in experimental resultsArticle Published on 2022-10-312022-11-16 Journal: Bioinformatics [Category] COVID19(2023년), meta-analysis, SARS, [키워드] addition aggregation Algorithm Apoptosis automated Bacteria biological process Cancer Cell Characteristics code Consensus database dataset datasets disease downloaded Evaluating Features genomic data heterogeneity implementation implicated Inclusion information lack list of gene lung cancer Macrophage Meta-analysis noise level question reliability required resulting specific type Support the SARS-CoV-2 virus Variation was performed were used [DOI] 10.1093/bioinformatics/btac621 PMC 바로가기
Autophagy and Mitophagy-Related Pathways at the Crossroads of Genetic Pathways Involved in Familial Sarcoidosis and Host-Pathogen Interactions Induced by Coronaviruses코로나바이러스에 의해 유도된 가족성 유육종증 및 숙주-병원체 상호작용에 관여하는 유전 경로의 교차로에서 자가포식 및 미토파지 관련 경로Comparative Study Published on 2021-08-052022-09-11 Journal: Cells [Category] MERS, 변종, 유전자 메커니즘, [키워드] abnormality accumulation acid Affect aggression Analysis antiviral response applied autophagy characterized Clustering Course COVID-19 COVID-19 pandemic deleterious mutation Deleterious mutations disease evaluate Exome Factor Factors Familial function functional gateway Genetic genetic defect genetic defects genetic factors Genetic predisposition genetics hallmark healthy individuals host response Hypothesis induced infectious inflammatory process involved list list of gene Lungs mammalian mitochondrial mitophagy mTOR Mutation pathogenic variant pathway Patient protocol Rapamycin Regulation retinoic acid risk sarcoidosis SARS-CoV2 SARS-CoV2 infection shown Signaling significant enrichment TANK Binding Kinase 1 target Viral viral infection viral infections web server [DOI] 10.3390/cells10081995 PMC 바로가기 [Article Type] Comparative Study
Why does SARS-CoV-2 hit in different ways? Host genetic factors can influence the acquisition or the course of COVID-19SARS-CoV-2가 다른 방식으로 공격하는 이유는 무엇입니까? 숙주 유전적 요인은 COVID-19의 획득 또는 경과에 영향을 미칠 수 있습니다Review Published on 2021-06-012022-09-11 Journal: European journal of medical genetics [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] acquisition Affect age association available data carried CD27 Comorbidities Course COVID-19 COVID-19 pandemic COVID19 cure Data mining death demonstrated distribution epidemiological epidemiological data Evidence evidence of Factor FIVE General population Genes genetic background genetic risk factor genetic risk factors Genetic variant Host Host genetic factor Infection inhibitor Innate immunity involved list list of gene MBL2 Mutation outcome polymorphism population distribution Population screening Prevalence protease Protein provide response SARS-CoV-2 SARS-COV-2 infection Serine serine 2 SNPs supported term text mining TMPRSS2 transmembrane variant [DOI] 10.1016/j.ejmg.2021.104227 PMC 바로가기 [Article Type] Review
Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19COVID-19와 관련된 숙주 유전자의 우선 순위를 지정하기 위한 동적 데이터 기반 메타 분석Meta-Analysis Published on 2020-12-182022-09-10 Journal: Scientific Reports [Category] MERS, 바이오마커, 유전자 메커니즘, 임상, 치료제, [키워드] Algorithm Betacoronavirus CD3E CD4 chromosome chromosome 3 conducted content COVID-19 COVID-19 pathogenesis CXCL10 cyclosporine data-driven datasets described disease-associated dynamic evaluate Evidence experiment Factor Factors FYCO1 GWAS Host host gene host genes human betacoronavirus IL1A Immunogenetics immunology implicated Infection Infectious diseases Interpretation list list of gene locus MERS MERS-CoV Meta-analysis Other PPIA Prognostic factor Prognostic factors resource robust SARS-CoV SARS-CoV-2 seasonal coronaviruses systematic review therapeutic target Therapies viral infection Weighting [DOI] 10.1038/s41598-020-79033-3 PMC 바로가기 [Article Type] Meta-Analysis
Identification of biological correlates associated with respiratory failure in COVID-19COVID-19에서 호흡 부전과 관련된 생물학적 상관 관계 식별Research Article Published on 2020-12-112022-09-10 Journal: BMC Medical Genomics [Category] MERS, SARS, 유전자 메커니즘, [키워드] analyses Analysis analyzed bioinformatics biological processe Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients curated Cutoff database determine Diseases downloaded epithelial explain false discovery rate Gene ontology Gene ontology analysis gene product Genes Genome-wide association study global public health GWAS identification implicated information input International Italy list list of gene loci mapped Ontology P -value p -values participant patients with COVID-19 polymorphism PPI protein-protein interaction recruited Respiratory failure Result risk SARS-CoV-2 single-nucleotide Single-nucleotide polymorphisms SNPs Spain unique genes was performed wound healing [DOI] 10.1186/s12920-020-00839-1 PMC 바로가기 [Article Type] Research Article
Designing a Network Proximity-Based Drug Repurposing Strategy for COVID-19Cell and Developmental Biology Published on 2020-10-062022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] aggregation approach candidate Clinical practice COVID-19 COVID-19 pandemic drug Drug repurposing drugs effective effort engage Epidemiology Gene Expression group Host host protein Infection Interaction knowledge list of gene mechanisms molecular network network analysis network medicine network propagation network-based organism outbreak pharmacologic (drug) therapy pharmacological target RANK repurposing Strategy target gene Target genes the disease the SARS-CoV-2 to define Treatment viral invasion viral replication virus virus infection [DOI] 10.3389/fcell.2020.545089 PMC 바로가기 [Article Type] Cell and Developmental Biology
De novo and inherited private variants in MAP1B in periventricular nodular heterotopia심실주위 결절성 이형에서 MAP1B의 드 노보 및 유전된 사적 변이체Research Article Published on 2018-05-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abnormality affected allele Analysis arising association Author Brain brain development caused chance Collapsing controls cortical de novo de novo mutation de novo mutations detrimental Diseases disorder driven by ENCODE epilepsy Exome exome sequencing expected explain fetal Genetic genetic risk Genetic variant genetic variants genome-wide significant heterozygous variant identify implicated incomplete penetrance indicate individual initial involved leads list of gene loci loss-of-function malformation MAP1B Migration Mutation Neuron neurons nonsynonymous occur one patient parent parents patients performed predominant Protein responsible sequence sequenced Sequencing the disease the patient transmitted variant variants [DOI] 10.1371/journal.pgen.1007281 PMC 바로가기 [Article Type] Research Article