LoDlimit of detection

[키워드] liquid chromatography mass spectrometry ACE2angiotensin-converting enzyme 2 Analysis analyzed angiotensin-converting enzyme 2 area under the curve Asymptomatic AUCarea under the curve Biomarker Cohort Concordance controls Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 testing COVID-19coronavirus disease 2019 CT cycle threshold demonstrated develop diagnostic Diagnostic method dithiothreitol DTTdithiothreitol E Proteinenvelope protein Emergency use authorization envelope protein EUAemergency use authorization FDAFood and Drug Administration Food and Drug Administration human donor human serum IgAimmunoglobulin A IgGimmunoglobulin G IgMimmunoglobulin M immunoglobulin A Immunoglobulin G immunoglobulin M immunoglobulins inactivated LC-MS limit of detection limitation LoDlimit of detection M Proteinmembrane protein MALDI-ToF MSmatrix-assisted laser desorption/ionization-time of flight mass spectrometry matrix-assisted laser desorption/ionization-time of flight mass spectrometry membrane protein N Proteinnucleocapsid protein nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs Non-invasive NPnasopharyngeal nucleocapsid protein pilot study platform positive individuals Protein proteome RBDReceptor Binding Domain receiver operating characteristic Receptor binding domain Reverse transcriptase quantitative polymerase chain reaction Ribonucleic acid RNARibonucleic acid ROCreceiver operating characteristic RT-qPCR S Proteinspike protein Saliva SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 virus SARS-CoV-2severe acute respiratory syndrome coronavirus 2 sensitivity severe acute respiratory syndrome coronavirus 2 specificity specimen Spike protein VEPviral envelope protein viral envelope protein WHOWorld Health Organization with COVID-19 World Health Organization
[DOI] 10.1016/j.jmsacl.2021.09.001 [Article Type] Research article