SUMMIT: An integrative approach for better transcriptomic data imputation improves causal gene identificationArticle Published on 2022-10-252022-11-16 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Accuracy Analysis approach association Blood build complex component COVID-19 severity dataset eQTL etiology explain expression Gene Expression Genetic Genome-wide association study identify IMPROVE loci low expression modeling moderate proportion provided Quantitative regulated severity Simulation study Statistical power traits transcriptome-wide transcriptomic data with COVID-19 [DOI] 10.1038/s41467-022-34016-y PMC 바로가기
Expression analysis of miRNA hsa-let7b-5p in naso-oropharyngeal swabs of COVID-19 patients supports its role in regulating ACE2 and DPP4 receptorsArticle Published on 2022-10-012022-11-15 Journal: Journal of Cellular and Molecular Medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 Analysis control sample coronavirus disease COVID-19 COVID-19 patient COVID-19 patients differential expression downregulation DPP4 enzyme Epigenetic functional Genes hsa-let7b-5p investigated involved low expression mechanism miRNA miRNAs modulation naso-oropharyngeal swab Novel coronavirus NPs overexpressed overexpression progression receptor Regulation reported respiratory responsible SARS-CoV-2 SARS-COV-2 infection significantly statistically significant Support the disease therapeutic target transcripts [DOI] 10.1111/jcmm.17492 PMC 바로가기
Identification of COVID-19-Associated DNA Methylation Variations by Integrating Methylation Array and scRNA-Seq Data at Cell-Type Resolution세포 유형 분해능에서 메틸화 어레이 및 scRNA-Seq 데이터를 통합하여 COVID-19 관련 DNA 메틸화 변이 식별Article Published on 2022-06-212022-09-11 Journal: Genes [Category] MERS, 바이오마커, [키워드] AHNAK antiviral activity biological processe Biomarker cell type cell types COVID-19 COVID-19 patient COVID-19 patients CX3CR1 Cytokines DNA DNA methylation DNAm variation gene Epigenetic FIVE identification immune immune dysfunction immune response immune responses Inflammatory response knowledge LFNG low expression lymphopenia Methylation methylation array phenomenon play roles pro-inflammatory cytokines regulated Regulation reported Resolution S100A9 scRNA-seq signaling pathways single-cell single-cell level specificity T cell T cells TRAF3IP3 Transcriptome Variation Whole blood [DOI] 10.3390/genes13071109 PMC 바로가기 [Article Type] Article
Evidence of Infection of Human Embryonic Stem Cells by SARS-CoV-2SARS-CoV-2에 의한 인간 배아 줄기 세포 감염의 증거Article Published on 2022-06-102022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 cell types coronavirus described differentially expressed dsRNA embryonic embryos enterocytes Evidence evidence of Gut hepatocytes hESC Human immunofluorescence microscopy infect Infection interferon-stimulated gene interferon-stimulated genes ISGs life cycle low expression mechanism neurons question replicate Replication replication of SARS-CoV-2 reported Respiratory system RNA S protein SARS-CoV-2 SARS-CoV-2 receptors severe acute respiratory syndrome Coronavirus significantly STEM stem cell supernatant supernatants Support syncytium threshold upregulated variety Viral RNA viral titer viral titers virion virus were infected [DOI] 10.3389/fcimb.2022.911313 PMC 바로가기 [Article Type] Article
Mechanism of COVID-19-Related Proteins in Spinal Tuberculosis: Immune Dysregulation척수결핵에서 COVID-19 관련 단백질의 메커니즘: 면역 조절 장애Article Published on 2022-06-022022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] Accuracy Analysis AUC B cell B cells bioinformatics C-index calculated calibration curve Cell clinical Clinical data collected coronavirus disease COVID-19 degree Diagnosis differentially expressed dysregulation enrichment analysis expression external validation Factor Gene ontology immune Immune cell immune cells immune dysregulation immune genes immune mechanism indicated Intersection intervertebral intervertebral disc involved KEGG KEGG pathway low expression Lymphocytes MCC mechanism mechanisms negative correlation nine nomogram PPI predicted Predictive Protein protein-protein interaction Proteins risk ROC Curve RPL19 significantly lower spinal spinal tuberculosis. suppress tissue tissues training set Tuberculosis was used were used [DOI] 10.3389/fimmu.2022.882651 PMC 바로가기 [Article Type] Article
A computational and bioinformatic analysis of ACE2: an elucidation of its dual role in COVID-19 pathology and finding its associated partners as potential therapeutic targetsACE2의 컴퓨터 및 생물정보학 분석: COVID-19 병리학에서 ACE2의 이중 역할에 대한 설명 및 잠재적인 치료 표적으로서 관련 파트너 찾기Article Published on 2022-03-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acting acute respiratory distress acute respiratory distress syndrome Acute respiratory distress syndrome Predicted ACE2 structure Analysis analyzed angiotensin Angiotensin-converting enzyme Angiotensin-converting enzyme -2 angiotensin-converting enzyme 2 ARDS bioinformatic analysis CDS Cell coding COVID-19 pandemic COVID-19 pathology determine Differentially expressed genes disease distress DNA sequence downregulation effort enzyme FOS FOXO4 FOXP2 healthy human lung tissue involved list low expression mechanism MiR-212-5p miRNA miRNA target miRNA targets miRNA-1246. pandemic pathological changes potential therapeutic target provide receptor respiratory distress Respiratory distress syndrome Spike protein Spread syndrome transcription factor transcription factors upregulation Vaccine viral entry viral spike protein [DOI] 10.1080/07391102.2020.1833760 PMC 바로가기 [Article Type] Article
Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19Research Article Published on 2022-01-102022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] abrogated Anti-inflammatory therapy anti-inflammatory treatment autocrine Bacterial Bacterial infection bacterial superinfection bacterial superinfections caused CD11b CD163 CD66b CD86 Cell cellular characterized classical Clusters complicate Course COVID-19 COVID-19 patient COVID-19 patients Critically ill CRP CXCR1 CXCR2 CXCR4 cytokine cytokine levels cytokine signaling Dexamethasone disease severity driven by dysregulated dysregulation elevated Ex vivo exacerbate exhibited expression function functional HLA-DR host response host-response hypercytokinemia Hyperinflammatory ICU IFN-γ IL-4 IL-6 level Immune cell immune cells immune response IMPROVE increased mortality induce Inflammatory marker inflammatory mediator Inflammatory mediators innate immune function Innate immunity low expression monocyte Monocytes MPO myeloid cell NET neutrophil paracrine paralysis patients phenotype phenotypic plasma provide receiving reduced reduction reduction in reflected response ROS production SARS-CoV-2 SARS-CoV-2 pathogenesis subsequent suppressed surface receptor Symptom synergistic systemic inflammation the disease TNF-α treated utility [DOI] 10.1371/journal.ppat.1010176 PMC 바로가기 [Article Type] Research Article
Signature of long-lived memory CD8 + T cells in acute SARS-CoV-2 infection급성 SARS-COV-2 감염에서 장기 기억 CD8 + T 세포의 시그니처Article Published on 2021-12-072022-08-31 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] accelerated acute infection acute SARS-CoV-2 infection acute viral infection adaptive Adaptive immunity Blood CCR7 CD45 CD45RA CD8 cells cellular characterized circulating clone clones COVID-19 pandemic effector memory evidence of Express facilitate flow cytometry hallmark IL-7 immune response Immunity Immunological memory Infection interferon low expression maintain memory memory T cell memory T cells outbreak pathogen patients with COVID-19 precursor precursors proliferation question Rapamycin Re-infection SARS-COV-2 infection SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells Sequencing signature stimulated T cell T cell receptor T cells transcriptional Transcriptome transcriptomes Viral viral infection [DOI] 10.1038/s41586-021-04280-x PMC 바로가기 [Article Type] Article
A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women소아 및 임산부에서 SARS-CoV-2에 대한 줄기 세포의 역할에 대한 검토Review Published on 2021-10-302022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] ACE/ACE2 active stem cells Adults angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Cell cell cycle children Clinical outcome condition conducted Contagion COVID-19 COVID-19 outbreak explain feature immunomodulatory Infection low expression mechanism molecular pattern pregnant women provide quiescent stem cell regenerative effect replicate Research responsible review role SARS-CoV-2 SARS-CoV-2 virus severity Spread STEM stem cell stem cells Symptom symptoms of COVID-19 the WHO Treatment unique women [DOI] 10.3390/ijms222111787 PMC 바로가기 [Article Type] Review
A Plausible Link of TMPRSS2/ACE2/AR Signaling to Male Mortality during the COVID-19 Pandemic in the United StatesBrief Report Published on 2021-10-262022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] ACE2 age Androgen receptor Breast contribute correlated correlation COVID-19 COVID-19 pandemic death ESR1 expression fatality females Gender Gene Expression incidence incidence of COVID-19 Infection intestine involved low expression lung male males men metabolism morbidity Mortality observation opposite Prostate receptor Regulation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral Signaling significantly higher Testosterone the United State The United States tissue TMPRSS2 viral infection women [DOI] 10.3390/pathogens10111378 PMC 바로가기 [Article Type] Brief Report