NLRC5 senses NAD + depletion to form a PANoptosome driving PANoptosis and inflammationArticle Published on 2024-06-122024-09-05 Journal: Cell [Category] update2024, [키워드] Apoptosis ASC caspase caspase-1 caspase-3 caspase-7 caspase-8 Colitis creatinine DAMP DSS gasdermin D gasdermin E heme Hemolysis hemophagocytic lymphohistiocytosis Inflammasome Inflammation Inflammatory cell death LPS MLKL necroptosis nicotinamide adenine dinucleotide NLRC5 NLRP12 NLRP3 Pam3CSK4 PAMP PANoptosis PANoptosome Phenylhydrazine poly(I:C) pyroptosis RIPK3 ROS TLR2 TLR4 TLRs TNF [DOI] 10.1016/j.cell.2024.05.034 PMC 바로가기 [Article Type] Article
Proteomic analysis and protein structure prediction of Shigella phage Sfk20 based on a comparative study using structure prediction approachesarticle Published on 2024-05-312024-09-01 Journal: Proteins: Structure, Function, and Bioinformatics [Category] 세균성이질, [키워드] AlphaFold2 ESMFold LC–MS/MS LPS Lytic Phyre2 Shigella phage [Article Type] article
Collateral sensitivity increases the efficacy of a rationally designed bacteriophage combination to control Salmonella enterica부가적 민감성은 살모넬라 엔테리카를 제어하기 위한 합리적으로 설계된 박테리오파지 조합의 효능을 증가시킨다.Article Published on 2024-03-192024-08-21 Journal: Journal of virology [Category] 살모넬라증, [키워드] antimicrobial BtuB collateral sensitivity LPS phage TraDIS
Advantages and disadvantages of treatment of experimental ARDS by M2-polarized RAW 264.7 macrophagesResearch Article Published on 2023-11-012024-09-05 Journal: Heliyon [Category] update2024, [키워드] ARDS immune system Inflammation LPS lung Macrophage polarization therapy [DOI] 10.1016/j.heliyon.2023.e21880 PMC 바로가기 [Article Type] Research Article
Shigella IpaH9.8 limits GBP1-dependent LPS release from intracytosolic bacteria to suppress caspase-4 activationShigella IpaH9.8은 GBP1 의존적인 LPS 방출을 세포 내 박테리아에서 제한하여 caspase-4 활성화를 억제합니다.Article Published on 2023-04-112024-08-22 Journal: Microbial Cell Factories [Category] 세균성이질, [키워드] Caspase-4 GBP1 Inflammasome LPS
Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathwayArticle Published on 2023-01-302022-11-16 Journal: Journal of ethnopharmacology [Category] 신종인플루엔자, 치료기술, [키워드] acute lung injury analyzed Anti-inflammation Apoptosis approved attenuate BALF Bcl-xL caspase Cell changes China confocal microscope coronavirus COVID-19 declined downstream drug Effect expression fatal complication flow cytometry food Granule H1N1 influenza histological histopathological IL-1β IL-6 immunofluorescence Infectious disease Influenza virus inhibited injection intrinsic investigated Jinhua Qinggan granules LPS lung Lung injury Lungs material mechanism mice Mild mitochondrial apoptotic pathway moderate morbidity and mortality MPO neutrophil Neutrophil apoptosis novel coronavirus disease Nuclear factor kappa-B nuclei p65 pathway pharmacological positive proportion Protein protein concentration protein expression pulmonary inflammation receptor reduced Respiratory disease Respiratory virus infection Signaling signaling pathway significantly staining survival survival rate TLR4 TNF-α toll-like receptor 4 treated Treatment were assessed were measured [DOI] 10.1016/j.jep.2022.115763 PMC 바로가기
Acute respiratory distress syndrome enhances tumor metastasis into lungs: Role of BRD4 in the tumor microenvironmentArticle Published on 2023-01-092024-09-05 Journal: International immunopharmacology [Category] update2024, [키워드] BRD4 LPS Lung inflammation p65 and STA3 nuclear translocation tumor metastasis [DOI] 10.1016/j.intimp.2023.109701 PMC 바로가기 [Article Type] Article
Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in miceArticle Published on 2022-11-012022-11-15 Journal: Inflammation research : official journal of the Eu [Category] 유전자 메커니즘, 진단, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome alleviate Analysis Anti-inflammatory anti-inflammatory property anti-inflammatory response ARDS CFZ Clofazimine coronavirus disease COVID-19 Critical decrease disease Diseases distress down-regulate histological change hyperimmune response IL-1β immune IMPROVE increasingly Infectious disease Inflammatory information inhibit involved lipopolysaccharide LPS lung Lung injury Macrophage macrophages mechanism mice Molecular biology pathway pharmacological mechanism potential molecular profile proliferation protective effect Protein protein expression Proteomic analysis proteomics Pulmonary edema Quantitative Signal transduction Signaling significantly survival rate syndrome therapeutic strategy TNF-α [DOI] 10.1007/s00011-022-01623-w PMC 바로가기
Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infectionArticle Published on 2022-10-042022-11-16 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome chromosomal Compound coronavirus Coronavirus infection CP: Immunology Effect Effects highlighting human macrophages identify induce influenza A inhibit inhibitor innate immune innate immune training LPS LPS tolerance Macrophage memory modulate modulation Necrosis NFAT-2 OC43 pro-inflammatory cytokine pro-inflammatory cytokines promote promoter prophylactic treatment reported rutaecarpine. SARS-CoV-2 SARS-COV-2 infection secretion small molecule susceptibility Syk inhibition TNF Tolerance Topology variant [DOI] 10.1016/j.celrep.2022.111441 PMC 바로가기
COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctionsArticle Published on 2022-10-012022-11-15 Journal: European Journal of Immunology [Category] 바이오마커, [키워드] accompanied Biomarker blood leukocyte Cell cells COVID-19 COVID-19 patients cytokine production Cytokines dendritic cell dendritic cells dysfunction hyporesponsiveness increase induce innate immune innate immune cell Intervention LPS Monocytes myeloid-derived suppressor cells sustained target upregulation [DOI] 10.1002/eji.202249827 PMC 바로가기