Regionally distinct progenitor cells in the lower airway give rise to neuroendocrine and multiciliated cells in the developing human lungBiological Sciences Published on 2023-06-062024-09-05 Journal: Proceedings of the National Academy of Sciences of [Category] update2024, [키워드] Basal cell bud tip progenitor lung organoid multiciliated cell neuroendocrine cell [DOI] 10.1073/pnas.2210113120 PMC 바로가기 [Article Type] Biological Sciences
The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapyarticle Published on 2023-04-282024-09-05 Journal: Stem Cell Research & Therapy [Category] update2024, [키워드] COVID-19 lung organoid Lung spheroid Natural polymers Synthetic polymers [DOI] 10.1186/s13287-023-03341-4 PMC 바로가기 [Article Type] article
Human lung organoid: Models for respiratory biology and diseasesReview Published on 2023-02-012023-07-11 Journal: Developmental biology [Category] COVID19(2023년), [키워드] in vitro model lung organoid Lung stem cell SARS-CoV-2 [DOI] 10.1016/j.ydbio.2022.12.001 [Article Type] Review
SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse ModelArticle Published on 2022-10-162022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] animal model B.1.1.7 B.1.1.7 variant expected greater higher infectivity Human immune system human lung tissue humanized humanized mice immune cells Immune profile immune response Immunity Infection Infectivity lesion Lineage lung lung organoid mice Model mouse no difference overlapping Pathogenesis pathogenesis of SARS-CoV-2 profile replication of SARS-CoV-2 required Research SARS-CoV-2 SARS-COV-2 infection similarity Support supported sustained Th1 Th2 variant variants of concern Viral load viral variant Viral variants virus [DOI] 10.3390/v14102272 PMC 바로가기
Mechanisms of Lung Injury Induced by SARS-CoV-2 InfectionSARS-CoV-2 감염으로 인한 폐 손상 기전Review Published on 2022-03-012022-09-11 Journal: Physiology (Bethesda, Md.) [Category] SARS, 치료제, [키워드] Anti-inflammatory antiviral therapeutics cause chemokine COVID-19 direct viral infection endothelial injury help identify immune immunomodulatory induced lung lung epithelial Lung injury lung organoid mechanism mitigate organ provide SARS-CoV-2 SARS-COV-2 infection target target organ therapeutic approaches Therapeutics viral infection [DOI] 10.1152/physiol.00033.2021 PMC 바로가기 [Article Type] Review
The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate TherapeuticsResearch Article Published on 2022-02-152022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Administered Air-liquid interface air-liquid interface (ALI) culture airway Airway organoids airways ALI cultures basolateral compartment challenge cilia ciliary ciliated cell circulation coronavirus coronavirus 2 Culture Cytokines Efficacy epithelium evaluated event Ex vivo feasibility generate Human human airway human respiratory virus human respiratory viruses immunoprophylaxis immunotherapies Infants Infection innate immune responses invasive lung organoid Model Mucus noninvasive technique nose nose organoids occurred Organoid organoids palivizumab Pathogenesis Patient predict Prevent prevented respiratory respiratory syncytial virus respiratory syncytial virus (RSV) respiratory viral respiratory virus RSV SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Therapeutics unmet need viral infection viral shedding [DOI] 10.1128/mbio.03511-21 PMC 바로가기 [Article Type] Research Article
Establishment of human distal lung organoids for SARS-CoV-2 infectionCorrespondence Published on 2021-11-092022-10-31 Journal: Cell Discovery [Category] COVID-19, [키워드] adult stem cells cell growth distal lung organoid SARS-COV-2 infection [DOI] 10.1038/s41421-021-00346-2 PMC 바로가기 [Article Type] Correspondence
Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19성체 줄기 세포 유래 완전한 폐 오르가노이드 모델은 COVID-19에서 폐 질환을 모방합니다Tools and Resources Published on 2021-08-132022-09-12 Journal: eLife [Category] MERS, 진단, [키워드] airway airway epithelia alveolar Alveolar Type II AT2 AT2 differentiation cause Cell cells center clinical Cohort Complete component computational COVID-19 COVID-19 pathogenesis Critical Diego disease modeling distal finding Host immune response Human human lung Illumina immune response immunologist in vitro include lung Lung disease lung organoid manuscript Medicine monolayer NIH NovaSeq 6000 pneumocyte Program proximal Respiratory samples responsible SARS-CoV-2 SARS-CoV2 scientist STEM supported sustained System therapy transcriptomic Vaccines viral infection virus viruses were infected widespread [DOI] 10.7554/eLife.66417 PMC 바로가기 [Article Type] Tools and Resources
Advancing lung organoids for COVID-19 researchOrganoids Published on 2021-06-012022-10-31 Journal: Disease Models & Mechanisms [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Advancing Antiviral Cell cellular collaboration coronavirus COVID-19 pandemic COVID-19 research develop effective lung organoid lung organoids Model model system pandemic pulmonary Research resources SARS-CoV-2 SARS-CoV-2 pathogenesis Treatment virus viruses [DOI] 10.1242/dmm.049060 PMC 바로가기 [Article Type] Organoids
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men안드로겐 신호는 SARS-CoV-2 수용체 수준을 조절하고 남성의 심각한 COVID-19 증상과 관련이 있습니다Article Published on 2020-12-032022-09-11 Journal: Cell Stem Cell [Category] Fulltext, MERS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] 5-alpha reductase inhibitors ACE2 ACE2 expression ACE2 regulation Analysis androgen androgen signaling angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding Cell cell membrane Clinical data Compound COVID-19 COVID-19 patient COVID-19 risk factors COVID-19 sex bias deep learning demonstrated disease disease severity disease susceptibility Diseases drug drug re-purposing elevated embryonic embryonic stem cell enzyme Genetic variant genetic variants Health Health crisis high content screening hPSC-based disease modeling identify Infection Level lung organoid lung organoids mechanism men occur offer potential treatment option Prostate reduce reduced risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection model screening strategy Sex stem cell susceptibility target the cell the disease virtual drug screen. virus [DOI] 10.1016/j.stem.2020.11.009 PMC 바로가기 [Article Type] Article