Macromolecule–Nanoparticle-Based Hybrid Materials for Biosensor ApplicationsReview Published on 2024-05-282024-09-05 Journal: Biosensors [Category] update2024, [키워드] amino acids biomolecules biosensor Cancer cells cholesterol Dopamine Glucose hydrogen peroxide limit of detection Limit of quantification Macrocycles macromolecules sensitivity uric acid [DOI] 10.3390/bios14060277 PMC 바로가기 [Article Type] Review
Multiplex Hybrid Antigen-Capture LC-MRM Quantification in Sera and Nasal Lining Fluid of AZD7442, a SARS-CoV-2-Targeting Antibody CombinationArticle Published on 2022-11-012022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] antibodies antibody applicability approach binding capture reagent clinical analysis Combination complementarity-determining region conditions coronavirus disease Critical demonstrated domain extension Final hybrid implementation Infection Ligand limit lining mAb macromolecules Magnetic beads matrix effect monoclonal antibody multidimensional nasal offer patient population peptide performed platform quantification reagent reagents reproducibility required sensitivity serum significantly Tandem mass spectrometry Treatment vaccination viral spike protein [DOI] 10.1021/acs.analchem.2c01320 PMC 바로가기
Exploring the anti-SARS-CoV-2 main protease potential of FDA approved marine drugs using integrated machine learning templates as predictive toolsArticle Published on 2022-11-012022-11-15 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 치료제, [키워드] activity Activity atlas model Activity cliff Algorithm anti-SARS-CoV-2 approved Atla Biological camostat Compound COVID-19 COVID-19 pandemic Cresset data set docked drug drugs effective FDA field Field template FIVE flare group Holichondrin B inactive macromolecules Marine drugs. nafamostat outbreak Predictive protease Protein remained Repurposed drug responsible Safe SARS-CoV-2 Structure structures [DOI] 10.1016/j.ijbiomac.2022.09.086 PMC 바로가기
Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2SARS-CoV-2에 대한 활성을 갖는 광범위한 1차 항바이러스제로서의 거대분자 바이러스 진입 억제제Article Published on 2022-07-012022-09-11 Journal: Advanced Science [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity analyzed antiviral activity broad-spectrum antivirals Cell culture cell entry clinical isolates entry inhibitors gold Gold nanoparticle in vitro in vivo inhibitor inhibitors inhibitory activity investigated isolate macromolecular macromolecules mice pathogen Pathogens polyanions quantified respiratory syncytial virus respiratory syncytial virus (RSV). respiratory viral respiratory viruses Result RSV SARS-CoV-2 shown STYRENE sulfonate tested translational variants variants of concern viral cell virus viruses [DOI] 10.1002/advs.202201378 PMC 바로가기 [Article Type] Article
Interactions of Co, Cu, and non-metal phthalocyanines with external structures of SARS-CoV-2 using docking and molecular dynamicsArticle Published on 2022-02-282022-10-04 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 치료제, [키워드] Adsorption antagonist approach approaches atomic candidate caused Characteristics characterized Cobalt Computational models Computational neuroscience Computational platforms and environments Contamination contribute copper COVID-19 pandemic deviation docking Dynamics envelope protein Gibbs free energy glycoprotein information inhibitor Interaction lethality rate Ligand macromolecules Masks molecular Molecular docking study molecular dynamics New coronavirus occur predict protease Proteases Protein analysis Protein function predictions provided residue SARS-CoV-2 Software solvent spike Structure structures Virtual drug screening virus were used [DOI] 10.1038/s41598-022-07396-w PMC 바로가기 [Article Type] Article
Modeling in the Time of COVID-19: Statistical and Rule-based Mesoscale ModelsArticle Published on 2021-11-182022-10-29 Journal: IEEE transactions on visualization and computer graphics [Category] COVID-19, MERS, [키워드] 3D model applicability approach Characteristics defined determine distribution effort element Evidence geometric information Interaction knowledge macromolecular macromolecules membrane mesoscale modeling Microscopy Model modeling molecular visualization outer membrane Research resulting Spread statistical structures the SARS-CoV-2 time ultrastructure virion virus [DOI] 10.1109/TVCG.2020.3030415 PMC 바로가기 [Article Type] Article
Developments in Treatment Methodologies Using Dendrimers for Infectious DiseasesReview Published on 2021-05-312022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] antibody Antimicrobial therapy Antiviral agents antiviral therapy Bacteria biochemical Compound contrast agent dendrimer dendrimers development diagnostic diagnostics Diseases drug delivery genetic material Infectious disease Infectious diseases macromolecules medium methodology MRI Nanoparticles parasites peptide polymers potential therapy structural property substrate therapeutic Transport Vaccine viruses [DOI] 10.3390/molecules26113304 PMC 바로가기 [Article Type] Review
Nanobioengineered Sensing Technologies Based on Cellulose Matrices for Detection of Small Molecules, Macromolecules, and CellsReview Published on 2021-05-242022-10-27 Journal: Biosensors [Category] COVID-19, [키워드] biosensors Cell Cellulose cytosensing described detection develop Diagnosis diagnostics human health Laboratory macromolecules matrix design metal ions Modification molecules nanobioengineering recent reported Small molecules technology trend unique [DOI] 10.3390/bios11060168 PMC 바로가기 [Article Type] Review
The evolution of commercial drug delivery technologies Reviews Published on 2021-04-012022-10-05 Journal: Nature biomedical engineering [Category] 신약개발, [키워드] antibodies approach article Compliance contribute drug Evolution Health identify IMPROVE include initial macromolecules nucleic acids Patient peptides Protein review small molecule therapeutic Therapies [DOI] 10.1038/s41551-021-00698-w [Article Type] Reviews
Effects of Cell Proteostasis Network on the Survival of SARS-CoV-2Review Published on 2021-02-222022-10-27 Journal: Biological Procedures Online [Category] COVID-19, [키워드] addition Apoptosis association Autoimmune Autoimmunity Cell chaperone chaperones contribute coronavirus COVID-19 Degradation Effect Endoplasmic reticulum ENhance epitope ER stress Evidence expression Factor Gene Expression heat shock protein Host Hsps immune system include increase in induce infect Infection Interaction macromolecules molecular Necrosis network Part Protein protein synthesis Proteins proteolytic Proteostasis Reactions replicate SARS-CoV-2 SARS-COV-2 infection severe SARS-CoV-2 Spread Stress target cells unfolded protein response UPR viral infection Viral protein virus [DOI] 10.1186/s12575-021-00145-9 PMC 바로가기 [Article Type] Review