The catalytic mechanism of the RNA methyltransferase METTL3Structural Biology and Molecular Biophysics Published on 2024-03-122024-09-05 Journal: eLife [Category] update2024, [키워드] bisubstrate analogue Compelling Human Important methyl transfer METTL3 transition state [DOI] 10.7554/eLife.92537 PMC 바로가기 [Article Type] Structural Biology and Molecular Biophysics
Dynamics of N6-methyladenosine modification during Alzheimer’s disease developmentResearch Article Published on 2024-02-252024-09-05 Journal: Heliyon [Category] update2024, [키워드] ALKBH5 Alzheimer's disease METTL3 microglia N6-methyladenosine WTAP [DOI] 10.1016/j.heliyon.2024.e26911 PMC 바로가기 [Article Type] Research Article
Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritisarticle Published on 2023-07-032024-09-05 Journal: Molecular Medicine [Category] update2024, [키워드] ADAMTS12 IGF2BP2 Inflammation METTL3 Osteoarthritis Stat1 [DOI] 10.1186/s10020-023-00661-2 PMC 바로가기 [Article Type] article
METTL3 inhibition ameliorates liver damage in mouse with hepatitis B virus-associated acute-on-chronic liver failure by regulating miR-146a-5p maturationArticle Published on 2022-04-012023-06-11 Journal: Biochimica et biophysica acta. Gene regulatory mechanisms [Category] B형 간염, [키워드] Acute-on-chronic liver failure Hepatitis B virus Liver cell damage m(6)A methylation METTL3 miR-146a-5p [DOI] 10.1016/j.bbagrm.2021.194782
Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and ReplicationResearch Article Published on 2021-07-062022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome affected Analysis caused complex coronavirus disease Coronavirus-2 cytoplasm demonstrated Direct RNA sequencing distribution evaluated expression function Host immunoprecipitation knockdown mechanism methylated RNA methyltransferase-like 3 METTL3 Modification modulate N6-methyladenosine nucleus overexpression pandemic plasmid transfection Protein RdRP reported respiratory respiratory syndrome coronavirus-2 RNA RNA modification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 RNA Sequencing Transcriptome Viral protein viral replication Viral RNA [DOI] 10.1128/mBio.01067-21 PMC 바로가기 [Article Type] Research Article
METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infectionMETTL3은 SARS-CoV-2 감염 동안 바이러스 m6A RNA 변형 및 숙주 세포 선천성 면역 반응을 조절합니다Article Published on 2021-05-112022-09-11 Journal: Cell Reports [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adenosine binding clade coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 treatment decrease disease downstream ENhance expression Gene Expression Host host cell host genes Host immune response host innate immunity increase Inflammation Inflammatory inflammatory gene inflammatory genes innate immune innate immune response Innate immunity m(6)A RNA modification. methyltransferase METTL3 Modification molecular mechanism Patient physiological reduced reduction in regulate RIG-I RNA RNA modification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severe coronavirus disease signaling pathway the SARS-CoV-2 the SARS-CoV-2 virus Treatment viral genome Viral RNA widespread [DOI] 10.1016/j.celrep.2021.109091 PMC 바로가기 [Article Type] Article