Delivery of anti-microRNA-21 by lung-targeted liposomes for pulmonary fibrosis treatmentOriginal Article Published on 2023-02-282024-09-05 Journal: Molecular Therapy. Nucleic Acids [Category] update2024, [키워드] COVID-19 drug delivery liposomes microRNA miR-21 MT: Oligonucleotides: Therapies and Applications pulmonary fibrosis [DOI] 10.1016/j.omtn.2023.02.031 PMC 바로가기 [Article Type] Original Article
Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDSSARS-CoV-2에 의해 유발된 ARDS 생존자의 폐 기능 및 방사선학적 특징과 관련된 순환 microRNA 프로파일 식별Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory distress syndrome Anti-inflammatory ARDS association carbon monoxide cell death Chest computed tomography circulating Coagulation Complete composed Computed tomography conducted correlated COVID-19 develop diffusing diffusing capacity distress enrichment analyses enrichment analysis evaluated Evidence evidence of feature Features Follow-up Gene ontology genomes hospital discharge hypoxia identification immune response infected patient infected patients KEGG KEGG pathway Kyoto lung Lung function median microRNA miR-126 miR-146 miR-146a-5p miR-21 miR-9 miRNA miRNA profiles miRNA profiling miRNA signature molecular molecular mechanism molecular mechanisms Pathogenesis pathophysiology pathway Patient patients predicted profile provided Pulmonary function radiologic radiological feature radiological features Random forest respiratory distress Respiratory distress syndrome RT-qPCR SARS-COV-2 infection secondary to Sequelae severe COVID-19 severity survivor to define Total severity score Trial registration TSS vascularization viral infection was performed was used [DOI] 10.1080/22221751.2022.2081615 PMC 바로가기 [Article Type] Article
miR-155: A Potential Biomarker for Predicting Mortality in COVID-19 PatientsArticle Published on 2022-02-212022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] acute respiratory syndrome addition Admission assist Biomarker Biomarkers Blood Care caused circulating circulating miRNA Clinical course coronavirus 2 COVID-19 COVID-19 mortality COVID-19 patients diagnostic discharged home disease disease severity expression healthy hospital hospitalized COVID-19 patient IMPROVE less mild COVID-19 patient miR-155 miR-21 miRNAs pandemic Patient Peripheral blood Potential predictor of mortality prognostic biomarker quantitative PCR SARS-CoV-2 severe COVID-19 disease Support therapeutic [DOI] 10.3390/jpm12020324 PMC 바로가기 [Article Type] Article
Conserved MicroRNAs in Human Nasopharynx Tissue Samples from Swabs Are Differentially Expressed in Response to SARS-CoV-2Article Published on 2022-02-142022-10-31 Journal: Genes [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] conserved contribute differentially expressed differentially expressed miRNA disease expression level groups Human humans miR-21 miRNA miRNA profile miRNA profiles miRNAs modifications nasopharynx non-infected patients positive real-time RT-PCR response RNA RNA sample RNA sequencing Sample SARS-CoV-2 SARS-CoV-2 pathogenesis selected small RNA sequencing Symptom the SARS-CoV-2 tissue tissue sample tissues various tissues were expressed [DOI] 10.3390/genes13020348 PMC 바로가기 [Article Type] Article
miRNAs, from Evolutionary Junk to Possible Prognostic Markers and Therapeutic Targets in COVID-19miRNA, 진화 적 쓰레기에서 가능한 예후 마커 및 covid-19의 치료 표적까지Review Published on 2021-12-272022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] addition among others Antiviral treatment cellular Complication complications COVID-19 COVID-19 pandemic COVID-19 patients cytokine Cytokine storm element Exacerbation Genes Genetic genetic regulation high risk highlight Host identify increased expression inflammatory process intensive care intensive care unit Interaction microRNA miR-122 miR-155 miR-200 miR-21 miRNA miRNAs molecular Mortality neuronal pathophysiology Patient predictor Prognosis prognostic public health Regulation renal required risk SARS-CoV-2 target the disease therapeutic therapeutic targets Viral virus [DOI] 10.3390/v14010041 PMC 바로가기 [Article Type] Review
Circulating Extracellular Vesicles Carry Immune Regulatory miRNAs and Regulate Vaccine Efficacy and Local Inflammatory Response After VaccinationImmunology Published on 2021-06-152022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Adverse reaction Biomarker Control coronavirus disease creating cytokine Cytokines Diseases Efficacy EVs expected expression extracellular vesicle IL-12 IL-6 IL-6 expression IL-6-dependent immune response IMPROVE individual individuals Inflammatory Innate immunity Local lymphoid cells mice microRNA miR-21 miRNA miRNAs negative feedback loop predict Prophylaxis reduce reducing regulate required response seasonal flu serum Symptom Th1 type I interferon vaccination vaccination efficacy Vaccinations Vaccine [DOI] 10.3389/fimmu.2021.685344 PMC 바로가기 [Article Type] Immunology
Decreased serum levels of the inflammaging marker miR-146a are associated with clinical non-response to tocilizumab in COVID-19 patients염증 마커 miR-146a의 감소된 혈청 수준은 COVID-19 환자에서 토실리주맙에 대한 임상적 무반응과 관련이 있습니다Clinical Trial Published on 2021-01-012022-09-11 Journal: Mechanisms of ageing and development [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] accounted adverse outcome affected age anti-IL-6 receptor biologic Biomarker Clinical course clinical response clinical trial COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity current death Decreased develop Digital disease droplet enrolled examined Health Healthcare systems healthy control inflammaging interleukin-6 interstitial pneumonia intravenous intravenous infusion lowest marker microRNA MicroRNAs miR-126 miR-146 miR-146a-5p miR-21 molecular non-responders Patient PCR quantified regulate respond responders RT-PCR Serum level serum levels serum sample serum samples subjects syndrome TCZ Tocilizumab Treatment [DOI] 10.1016/j.mad.2020.111413 PMC 바로가기 [Article Type] Clinical Trial
Exploiting yoeB-yefM toxin-antitoxin system of Streptococcus pneumoniae on the selective killing of miR-21 overexpressing breast cancer cell line (MCF-7)article Published on 2020-03-312024-09-01 Journal: Journal of Cellular Physiology [Category] 폐렴구균 감염증, [키워드] Breast cancer cancer cell killing miR-21 Toxin-Antitoxin system YefM YoeB [Article Type] article
MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2Article Published on 2017-02-012023-06-24 Journal: The Journal of Allergy and Clinical Immunology [Category] 신종인플루엔자, [키워드] Airway hyperresponsiveness Chlamydia species Corticosteroids Haemophilus influenzae histone deacetylase 2 Influenza miR-21 PI3 kinase respiratory syncytial virus Severe asthma [DOI] 10.1016/j.jaci.2016.04.038
Expression of Serum Exosomal MicroRNA-21 in Human Hepatocellular Carcinoma인간 간세포 암종에서 혈청 엑소좀 MicroRNA-21의 발현Research Article Published on 2014-05-182022-08-08 Journal: BioMed Research International [Category] 임상, [키워드] advanced tumor stage Biomarker Biomarkers carcinoma CHB chronic hepatitis Chronic Hepatitis B cirrhosis Clinical significance Concentration correlated Diagnosis Diseases examined Exosome exosome-depleted supernatant exosome-depleted supernatants Exosomes expression expression level HCC HCC diagnosis healthy volunteer healthy volunteers Hepatocellular carcinoma Human indicated investigated microRNA MicroRNAs miR-21 miR-21 expression miRNAs much lower New Patient patients with HCC provide Quantitative RT-PCR sensitivity serum exosomal miR-21 serum exosome serum exosomes Serum level significantly higher Tumor whole serum [DOI] 10.1155/2014/864894 PMC 바로가기 [Article Type] Research Article