Immune memory shapes human polyclonal antibody responses to H2N2 vaccinationArticle Published on 2024-05-072024-09-05 Journal: Cell Reports [Category] update2024, [키워드] cryo-EM H2 hemagglutinin Influenza medial junction monoclonal neutralizing antibody polyclonal structure-based vaccine design [DOI] 10.1016/j.celrep.2024.114171 PMC 바로가기 [Article Type] Article
Monoclonal antibodies for the prevention of Plasmodium falciparum malaria: a multi-target approach?article Published on 2024-01-312024-09-01 Journal: Infectious Diseases [Category] 말라리아, [키워드] Immunity malaria monoclonal Plasmodium prevention Vaccine [Article Type] article
Long-term Prophylaxis Against Aerosolized Marburg Virus in Nonhuman Primates With an Afucosylated Monoclonal AntibodySupplement Article Published on 2023-11-152024-09-05 Journal: Nanoscale [Category] update2024, [키워드] aerosol antibody Marburg virus monoclonal [DOI] 10.1093/infdis/jiad278 PMC 바로가기 [Article Type] Supplement Article
Efficacy of pre-exposure prophylaxis to prevent SARS-CoV-2 infection after lung transplantation: a two center cohort study during the omicron eraarticle Published on 2023-03-162024-09-05 Journal: Infection [Category] update2024, [키워드] antibodies cilgavimab COVID-19 lung transplantation monoclonal pre-exposure prophylaxis Prophylaxis SARS-CoV-2 Tixagevimab [DOI] 10.1007/s15010-023-02018-7 PMC 바로가기 [Article Type] article
The prominent role of a CDR1 somatic hypermutation for convergent IGHV3-53/3-66 antibodies in binding to SARS-CoV-2SARS-CoV-2에 결합하는 수렴형 IGHV3-53/3-66 항체에 대한 CDR1 체세포 과돌연변이의 두드러진 역할Article Published on 2022-12-012022-09-12 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome Analysis antibodies antibody antibody affinity binding binding affinity Cdr1 contributed Coronavirus-2 COVID-19 Frequency functional germline gene Humoral immunity IGHV3-53/3-66 knowledge mAb mAbs monoclonal monoclonal antibody Mutation other coronaviruses SARS-CoV-2 Somatic hypermutation somatic hypermutations Treatment [DOI] 10.1080/22221751.2022.2063074 PMC 바로가기 [Article Type] Article
Preclinical assessment and randomized Phase I study of CT-P63, a broadly neutralizing antibody targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Article Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome Beta Blood caused clinically Concentration coronavirus COVID-19 creatine phosphokinase CT-P63 deaths declining Delta demonstrated detectable dose double-blind evaluated groups healthy volunteer Immunity in vitro in vivo Infection Infectious virus lung monoclonal monoclonal antibody morbidity and mortality mutated variant Neutralizing Neutralizing activity neutralizing antibody omicron pandemic parallel-group participant peaked phase Placebo placebo-controlled Preclinical prevalent Prophylactic Randomized reduced respiratory tract Safe SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants of concern Serious Adverse Events significantly single ascending dose study drug TEAE titre Tolerability Transgenic mouse treated Treatment treatment-emergent adverse event vaccination variants variants of SARS-CoV-2 wild-type [DOI] 10.1080/22221751.2022.2117094 PMC 바로가기
Converting non-neutralizing SARS-CoV-2 antibodies into broad-spectrum inhibitorsArticle Published on 2022-11-012022-11-15 Journal: Nature chemical biology [Category] SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome addition angiotensin-converting enzyme 2 antibody binding component conserved coronavirus defined Diseases epitope Epitopes highlighting inhibitor inhibitors inhibitory linker monoclonal neutralize Neutralizing activity non-neutralizing antibody omicron pandemic receptor SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 evolution SARS-CoV-2 variant target the SARS-CoV-2 Treatment viral spike protein VOCs [DOI] 10.1038/s41589-022-01140-1 PMC 바로가기
Resistance mutations in SARS-CoV-2 omicron variant after tixagevimab-cilgavimab treatmentArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infection [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Abstract cilgavimab monoclonal mutations neutralizing monoclonal antibodies Omicron variant Resistance mutation SARS-CoV-2 Sequencing Tixagevimab Treatment [DOI] 10.1016/j.jinf.2022.07.014 PMC 바로가기
Characterization of Casirivimab Plus Imdevimab, Sotrovimab, and Bamlanivimab Plus Etesevimab-Derived Interference in Serum Protein Electrophoresis and Immunofixation ElectrophoresisArticle Published on 2022-10-292022-11-15 Journal: The journal of applied laboratory medicine [Category] 진단, [키워드] added antibody assay interference B-cell bamlanivimab Casirivimab Cell characterization COVID-19 diagnostic Electrophoresis etesevimab evaluate evaluated Imdevimab Immunofixation immunofixation electrophoresis in vitro infused Interference medication monoclonal monoclonal antibody monoclonal antibody therapy neoplasm Patient patients plasma platform producing recognizing serum Serum protein serum protein electrophoresis serum sample serum samples Sotrovimab sustained tested therapeutic [DOI] 10.1093/jalm/jfac064 PMC 바로가기
Type D lymphomatoid papulosis with pityriasis lichenoides et varioliformis acuta-like features in a child with parvovirus infection: a controversial diagnosis in the spectrum of lymphoid proliferations: case report and literature reviewArticle Published on 2022-10-282022-11-16 Journal: Italian Journal of Pediatrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] Administered Alanine antigenic Aspartate aminotransferase Bilirubin C-reactive protein Case report CD8+/CD30+ cells children clinical response clinical suspicion Critical cytokine profile Cytokines Department Diagnosis differential diagnosis discharged disease disorder Emergency erythematous feature Fever histological history Hospitalized IFN-γ IL-10 IL-6 immunoglobulin M infectious agent infiltration introduced Laboratory test lesion lesions limits literature review lymphoid lymphomatoid Lymphomatoid papulosis lymphoproliferative Lymphoproliferative cutaneous disorders marker mechanism monoclonal morphologically necrotic Parvovirus parvovirus B19 pathogenic Perspective phenotype pityriasis lichenoides et varioliformis acuta. polymerase chain reaction positive response proliferation Rash recorded regions reported representing returned SARS-CoV-2 antigen separated skin lesions steroid Support Symptom systemic corticosteroid T-cell receptor Therapies Treatment Type Type D [DOI] 10.1186/s13052-022-01371-x PMC 바로가기