Evidence of SARS-CoV-2 convergent evolution in immunosuppressed patients treated with antiviral therapiesResearch Published on 2024-05-072024-09-05 Journal: Virology Journal [Category] update2024, [키워드] Antiviral treatment convergent evolution COVID-19 immunosuppressed patients iSNVs monoclonal antibody treatment SARS-CoV-2 evolution [DOI] 10.1186/s12985-024-02378-y PMC 바로가기 [Article Type] Research
Effectiveness of Sotrovimab in the Omicron Storm Time: A Case SeriesObservational Study Published on 2022-12-302023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] Chronic kidney disease Immune suppression monoclonal antibody treatment Omicron variant SARS-CoV-2 Sotrovimab variant of concern [DOI] 10.3390/v15010102 PMC 바로가기 [Article Type] Observational Study
Early Treatment with Monoclonal Antibodies or Convalescent Plasma Reduces Mortality in Non-Vaccinated COVID-19 High-Risk PatientsArticle Published on 2022-12-302023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] convalescent plasma coronavirus disease 19 monoclonal antibody treatment SARS-CoV-2 [DOI] 10.3390/v15010119 PMC 바로가기
Association between treatment failure and hospitalization after receipt of neutralizing monoclonal antibody treatment for COVID-19 outpatientsArticle Published on 2022-11-072022-11-16 Journal: BMC Infectious Diseases [Category] SARS, 변종, [키워드] 95% CI 95% confidence interval adjusted odds ratio Administered age Characteristics clinical trial Comorbidity COVID-19 COVID-19 outpatient death defined died early symptomatic COVID-19 effective Electronic health record health system Hospitalization Hospitalized immunocompromised status lack mAb mAbs Male sex Mild monoclonal antibodies monoclonal antibody monoclonal antibody treatment Mortality mortality data multicenter Neutralizing obesity Observational cohort study occurred pandemic Patient patients patients with COVID-19 positive Primary outcome real-world data reducing SARS-CoV-2 SARS-CoV-2 test SARS-CoV-2 vaccination Treatment Vaccine variants while [DOI] 10.1186/s12879-022-07819-z PMC 바로가기
Early identification of high-risk individuals for monoclonal antibody therapy and prophylaxis is feasible by SARS-CoV-2 anti-spike antibody specific lateral flow assayArticle Published on 2022-11-012022-11-15 Journal: Diagnostic microbiology and infectious disease [Category] SARS, 진단, 치료기술, [키워드] Abbott anti-spike antibodies anti-spike antibody antibody Antibody test Antibody titer appear approved Architect assist benefit CMIA correlated strongly COVID-19 detect effective feasible female IgM/IgG immune response Immune status immunoassay individual IQR Lateral lateral flow lateral flow assay log-linear regression median age Microparticle monoclonal antibody monoclonal antibody therapy monoclonal antibody treatment natural infection participant Patient Prophylaxis SARS-CoV-2 SARS-CoV-2 IgG sera seronegative patient Severe COVID-19 Infection tested therapy Treatment undergo vaccination [DOI] 10.1016/j.diagmicrobio.2022.115788 PMC 바로가기
Long-term cellular immune response in immunocompromised unvaccinated COVID-19 patients undergoing monoclonal antibody treatmentArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 Antigen cellular Cellular immune response cellular response clinical decision control groups Coronavirus-2 Course COVID-19 COVID-19 patient develop Effect ELISpot assay healthy control help High-risk patients immune Immunocompromised Immunocompromised patient Immunocompromised patients Immunosuppression increased risk Infection investigated mAb mAbs median monoclonal antibody monoclonal antibody treatment Patient patient cohorts SARS-CoV-2 SARS-COV-2 infection spike subject Treatment was determined [DOI] 10.3389/fimmu.2022.980698 PMC 바로가기
Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2Article Published on 2022-08-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] ACE2 receptor binding addition administration antibody Beta clearance contributed country COVID-19 COVID-19 pandemic creating delta variant disease dose doses Efficacy emergence EpF(ab’)2 equine Equine F(ab’)2 Fab HBsAg immunization implementation increased survival Infection intranasal K18-hACE2 K18-hACE2 transgenic mice mice monoclonal antibody treatment neutralize omicron outcome pandemic passive immunization peripheral circulation phenotype polyclonal polyclonal antibodies PROTECT RBD SARS-CoV-2 SARS-COV-2 infection Severe case severe disease severe SARS-CoV-2 strain survival tested therapeutic Therapeutic treatment tissues transgenic Treatment variant variant of concern (VOC) variants variants of concern variants of SARS-CoV-2 Viral RNA virus VoC [DOI] 10.3389/fimmu.2022.948431 PMC 바로가기
A pyrosequencing protocol for rapid identification of SARS-CoV-2 variantsSARS-CoV-2 변이체의 신속한 식별을 위한 파이로시퀀싱 프로토콜Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] (Alpha) (Beta) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha B.1.1 B.1.1.529 B.1.1.7 B.1.351 B.1.525 B.1.617.1 B.1.617.2 B.1.621 Beta circulating circulating variant circulating variants confidence Coronaviridae coronavirus costly Delta differentiation distribution effort Epsilon Eta Gamma geographical regions information Iota lineages MONITOR monoclonal antibody monoclonal antibody therapies monoclonal antibody treatment Mutation Next-generation sequencing NGS omicron Patient protocol pyrosequencing reported respiratory reverse transcription SARS-CoV-2 SARS-CoV-2 surveillance SARS-CoV-2 variant Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein Surveillance the United State therapy time-consuming United States variant variants [DOI] 10.1002/jmv.27770 PMC 바로가기 [Article Type] Article
Speed and need: twin development challenges in rapid response for a SARS-CoV-2 antibody cocktail속도와 필요성: SARS-CoV-2 항체 칵테일에 대한 신속한 대응을 위한 두 가지 개발 과제Review Published on 2022-08-012022-09-12 Journal: Current opinion in biotechnology [Category] MERS, SARS, 비임상, 진단, [키워드] addressed antibody Cell culture Combined COVID-19 treatment Diseases example Genentech knowledge management monoclonal antibody monoclonal antibody treatment Patient Process provided purification rapid response Regeneron risk SARS-CoV-2 antibody selected speed timeline transfer Treatment urgency worldwide pandemic [DOI] 10.1016/j.copbio.2022.102715 PMC 바로가기 [Article Type] Review
Administration of Anti-SARS-CoV-2 Monoclonal Antibodies After US Food and Drug Administration DeauthorizationArticle Published on 2022-08-012022-11-15 Journal: JAMA Network Open [Category] 진단, [키워드] administration cross-sectional drug evaluate food monoclonal antibody treatment SARS-COV-2 infection [DOI] 10.1001/jamanetworkopen.2022.28997 PMC 바로가기