Breakthrough Gastrointestinal COVID-19 and Intrahost Evolution Consequent to Combination Monoclonal Antibody ProphylaxisArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] amino acid change antiviral therapy Breakthrough infection Colon Consequent COVID-19 Deletion furin cleavage site Gastrointestinal gastrointestinal tract Infection intestinal low-dose monoclonal antibody mucosa mucosal nonhuman primates promote Prophylaxis rectal swab Replication rhesus SARS-CoV-2 suboptimal prophylaxis. tissue upper respiratory viral evolution viral replication Viral RNA virus virus stock [DOI] 10.1093/infdis/jiac134 PMC 바로가기
Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathologyArticle Published on 2022-09-292022-11-15 Journal: Vaccine [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Adaptive immune response addition antibodies antibody Beta Cell coronavirus coronavirus disease COVID-19 COVID-19 vaccines CpG cross-protective develop feature Gamma IgA antibody IgG antibody immunopathology Infection initial intranasal intranasal vaccination intranasally investigated less lung Lung eosinophilic immunopathology Lymph node mice mucosa nasal nasal mucosa oligonucleotides pandemic potential risk Prevent Protective protective effect reducing Respiratory disease risk SARS-CoV-2 SARS-CoV-2 variant secretory secretory IgA secretory IgA antibody. serum spike-specific IgG subcutaneous vaccination subcutaneously T helper Th1 Th2 Trimeric spike protein upper respiratory tract vaccination Vaccine variant variants viral challenge virus infection viruses [DOI] 10.1016/j.vaccine.2022.08.049 PMC 바로가기
A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamstersArticle Published on 2022-09-272022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome Administered Antiviral effect coronavirus COVID-19 pandemic delta variant Detection limit disease dose effective Efficacy exhibited hamster hamsters highest Infectious virus Inflammatory cytokines Intervention intranasally intrinsically limit Lipid nanoparticle Lower mucosa nasal Particle Pathogenesis Postinfection Prevent reduce reduced reported respiratory tissue respiratory virus SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 transmission SARS-CoV-2 viral shedding severe disease severe lung pathology significantly lower suppress tested therapeutic therapeutic interfering particles TIP tissue Transmissibility Transmission uninfected variants variants. viral loads viral replication while [DOI] 10.1073/pnas.2204624119 PMC 바로가기
How Do Anti-SARS-CoV-2 mRNA Vaccines Protect from Severe Disease?Article Published on 2022-09-082022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] adaptive alveolar alveolar macrophage Alveolar macrophages antiviral immunity approach benefit consequence COVID-19 Cytokine storm develop diffusion disease dissemination Efficacy elicited epithelial cell expected experimental evidence Extracellular Factor feature Host immune response immune function inhibitory effect intramuscularly Macrophage mechanism messenger mRNA mRNA vaccine mRNA vaccines mRNA vaccines. mucosa other tissue outcome Pathogenesis Prophylaxis Protein Quantitative respiratory respiratory symptom respiratory tracts SARS-CoV-2 severe disease spike Spread TGF-β the cytokine storm upper respiratory tracts Vaccine viral replication virus while [DOI] 10.3390/ijms231810374 PMC 바로가기
An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosaArticle Published on 2022-09-072022-11-15 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome adaptive addition anti-Spike IgG B cells Beta boost booster cellular immunity Central nervous system Complete coronavirus coronavirus disease COVID-19 COVID-19 vaccine cross-protective delta variant effective effector memory Host humoral Humoral immunity IgA Immunity immunization induce Infection inflammatory properties intranasal intranasal vaccination intranasally lentiviral lentiviral vaccine lung mice mRNA mucosa mucosal mucosal booster vaccine mucosal immunity nasal non-replicative omicron organism pandemic Protective reducing SARS-CoV-2 SARS-CoV-2 emerging variants of concern SARS-CoV-2 immunity shown specificity susceptible T cell target the SARS-CoV-2 transgenic mice vaccination vaccine candidate variant variants of concern Viral transmission waning anti-COVID-19 immunity. [DOI] 10.1016/j.ymthe.2022.04.016 PMC 바로가기
In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variantsArticle Published on 2022-09-052022-11-16 Journal: Acta Neuropathologica Communications [Category] SARS, 변종, [키워드] acute phase acute respiratory syndrome astrocytes B.1.1.529 B.1.617.2 Brain olfactory bulb Cell CNS co-cultured coronavirus cortical COVID-19 Culture D614G days post infection Delta hamster hamsters in vitro in vivo in vivo models Infection inoculated interferon isolate mechanism microglia activation mucosa Neuroinflammation neuroinvasion Neuroinvasive Neurological complications Neuron neurotropic neurotropism neurovirulence neurovirulent occur olfactory omicron performed reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2. shown the SARS-CoV-2 variant [DOI] 10.1186/s40478-022-01426-4 PMC 바로가기
SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19코로나19 사망자의 SARS-CoV-2 뇌 부위 검출, 조직병리학, 유전자 발현 및 면역조절 변화Article Published on 2022-08-162022-09-11 Journal: Journal of neuropathology and experimental neurolo [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] Amygdala arising Autopsies Autopsy Blood Brain brains cerebellar cortex change Control COVID-19 COVID-19 cases cytokine Deafferentation detection Differentially expressed genes downregulation Encephalitis fraction Gene Expression Genes Hemorrhagic hemorrhagic encephalitis Histopathology immune immune response indicated involved marker microglia mucosa neuronal Non-COVID-19 olfactory olfactory bulb portal receptor reduced reduction Region Regional RNA polymerase RNA sequence RNA sequences RNA-dependent RNA polymerase RNAseq RT-PCR S gene SARS-CoV-2 SARS-CoV-2 E gene SARS-CoV-2. sequence serum Significant subject upregulation viral sequence virus with COVID-19 [DOI] 10.1093/jnen/nlac056 PMC 바로가기 [Article Type] Article
Mucosal chemokine adjuvant enhances synDNA vaccine-mediated responses to SARS-CoV-2 and provides heterologous protection in vivo점막 케모카인 보조제는 SARS-CoV-2에 대한 synDNA 백신 매개 반응을 향상시키고 생체 내 이종 보호를 제공합니다Article Published on 2022-07-192022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant approach CCL27 CD8 cell-mediated response Cell-mediated responses chemokine claimed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta VOC DNA DNA plasmid DNA vaccine Efficacy ENhance Frequency Heterologous heterologous challenge humoral IFNγ immunogenicity immunological in vivo interferon gamma mucosa mucosal mucosal surface mucosal surfaces mucosal. pandemic Plasmid Protective provide respiratory respiratory mucosa response SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines significant effect Spike protein Spike-specific antibody T cell T cells unique Vaccine vaccine efficacy variants of concern Viral viral control VOCs wild-type [DOI] 10.1016/j.xcrm.2022.100693 PMC 바로가기 [Article Type] Article
COVID-19 associated with disseminated histoplasmosis in a kidney transplant patientArticle Published on 2022-07-012022-11-16 Journal: Revista Argentina de microbiología [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition adjusted Administered antifungal therapy Argentina Bacterial Chest computed tomography Chest CT clade community-acquired pneumonia Course COVID-19 COVID-19 infection diagnosed discharged English exhibited FIVE Fungal infection ground glass Histoplasma Histoplasma capsulatum Hospitalized immunosuppressive Infección fúngica intravenous kidney transplant lesions lobes mucosa nasopharyngeal sample Patient plasma reduced regimen renal Renal transplant respiratory symptom respiratory symptoms SARS-CoV-2 Spanish sputum the patient therapy Trasplante renal. treated Treatment Tuberculosis worsened [DOI] 10.1016/j.ram.2021.10.006 PMC 바로가기
Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic micehACE2 형질전환 마우스에서 SARS-CoV-2 감염 후 시간적 뇌 병변Article Published on 2022-07-012022-09-11 Journal: Veterinary pathology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis animal model astrogliosis Beta Brain cause Central nervous system Cerebellum characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 develop different time points distribution Encephalitis hACE2 hACE2-transgenic mice histopathological immunohistochemistry immunolabeling inoculation lesion meningoencephalitis mice mucosa necropsies necropsy Neuroinflammation Neurological disease neuronal neurons Neuropathology neuropathology. nonsuppurative olfactory other organ other organs panel of antibodies panel of antibody performed post inoculation processed question reached Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 lineage SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spongiosis Spread susceptible thrombosis transgenic mice vacuolar vacuolar degeneration variants Vasculitis virological assay virological assays virus [DOI] 10.1177/03009858211066841 PMC 바로가기 [Article Type] Article