The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic ApproachesArticle Published on 2022-09-132022-11-16 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Adapted CAMP Cancer cardiovascular diseases cascade cellular cGMP complex complexity contribute COVID-19 cyclic cyclic nucleotide phosphodiesterase (PDE) Depression diabetes disease drug design dysregulation emesis Evolution Fatty liver increases in Inflammation inhibitor Interaction interactome knowledge maintain malignancies multiplicity New nucleotide obesity organ Osteoporosis overcome pathologic Pathologies phosphodiesterase Phosphorylation physiological state problems receptors Regulation Research selective selective PDE4 inhibitor (PDE4-I). Signaling Specific subcellular Therapeutic approach tissue ulcerative colitis variant various tissue [DOI] 10.3390/ijms231810616 PMC 바로가기
Comparative Dynamics of Delta and Omicron SARS-CoV-2 Variants across and between California and Mexico캘리포니아와 멕시코 간의 Delta 및 Omicron SARS-CoV-2 변종 비교 역학Article Published on 2022-07-082022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] 95% CI accounted Analysis centric Comparative complex interplay COVID-19 Delta disease dispersal Dynamics Epidemics epidemiological data Epidemiology event events Evidence evidence of External Factor help increase in International limit Migration multiplicity no evidence of omicron peaked phylogeography reducing repeated response SARS-CoV-2 SARS-CoV-2 sequence sequence Spread Transmission Travel understanding unique vaccination variant variants viral epidemics viral spread Viral transmission while [DOI] 10.3390/v14071494 PMC 바로가기 [Article Type] Article
Adverse events following third dose of mRNA COVID-19 vaccination among nursing home residents who received the primary series1차 시리즈를 받은 요양원 거주자 중 mRNA COVID-19 백신 3차 접종 후 부작용Article Published on 2022-06-012022-09-11 Journal: Journal of the American Geriatrics Society [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI adjust Administered administration Adverse adverse event adverse events adverse events after vaccination booster booster COVID-19 vaccination booster dose CDC COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines dose Electronic health record Electronic health records event event rate event rates false discovery rate genesis Ischemic Stroke medical condition Medical conditions mRNA mRNA vaccine multiple comparisons multiplicity no significant differences nursing home nursing homes occurred prospective cohort reported resident Safety screened significant difference significant differences statistically significant tested vaccination rate venous Venous Thromboembolism [DOI] 10.1111/jgs.17812 PMC 바로가기 [Article Type] Article
Exploratory assessment of serological tests to determine antibody titer against SARS-CoV-2: Appropriateness and limitsSARS-CoV-2에 대한 항체가를 결정하기 위한 혈청학적 검사의 탐색적 평가: 적절성 및 한계Multicenter Study Published on 2022-05-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Analysis analyzed antibody Antibody titer Antibody titers appropriateness can be used Definition detect determine diagnostic diagnostic test diagnostic tests effective Effectiveness Elecsy Elecsys evaluated Health highlight IgA immunoassay Immunoglobulin immunoglobulins Infection International international standard International standards laboratory data limit limitation Luminex xMAP multicenter multiplex Multiplex assay multiplicity RBD resulting Roche S1 domain SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 test SARS-CoV-2 tests selected serological serological test Serological tests serum serum sample serum samples Siemen Spike protein Standard subject subjects the SARS-CoV-2 the WHO titer to define vaccination Variability WHO [DOI] 10.1002/jcla.24363 PMC 바로가기 [Article Type] Multicenter Study
Effect of Short Time of SARS-CoV-2 Infection in Caco-2 CellsCaco-2 세포에서 SARS-CoV-2 감염의 짧은 시간 효과Article Published on 2022-03-292022-09-11 Journal: Viruses [Category] SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting Caco-2 Caco-2 cell Caco-2 cell line Caco-2 cells Cell cell line children clinical manifestation clinical manifestations coronavirus coronavirus disease coronavirus disease 19 COVID-19 Cytopathic effect Effect epithelial cell epithelial cell line gastrointestinal tract highlight immunofluorescence immunofluorescence staining in vitro include infect intestinal multiplicity multiplicity of infection SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus short time of infection staining subsequent the viral nucleocapsid these cell These cells time viral absorption. was tested [DOI] 10.3390/v14040704 PMC 바로가기 [Article Type] Article
Capturing a Crucial ‘Disorder-to-Order Transition’ at the Heart of the Coronavirus Molecular Pathology—Triggered by Highly Persistent, Interchangeable Salt-BridgesArticle Published on 2022-02-162022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anionic appear arginine baseline being binding catalytic cationic characteristic cleavage site coronavirus COVID-19 disorder disorder-to-order transition enthalpy entropy compensation entropy arrest events Evolution feature FLCS flexible furin cleavage Genome heart homologous Host increase in Interaction interactions Lineage Molecular pathology motif multiplicity offer persistent polybasic Protein proteolytic proteolytic cleavage residue respiratory viral diseases respiratory viruses S1/S2 junction salt-bridge salt-bridge dynamics SARS-CoV SARS-CoV-2 spike Spike–Furin interaction the SARS-CoV-2 Transmissibility [DOI] 10.3390/vaccines10020301 PMC 바로가기 [Article Type] Article
Symptoms and risk factors for hospitalization of COVID-19 presented in primary care An exploratory retrospective study1차 진료실에서 제시한 코로나19 입원의 증상 및 위험인자 탐색적 후향적 연구Observational Study Published on 2022-02-112022-09-10 Journal: Wiener Klinische Wochenschrift [Category] COVID19(2023년), MERS, SARS, 임상, 치료기술, 치료제, [키워드] association Care conducted Course COVID-19 COVID‐19 criteria cross Data collection demographic data demographics Descriptive analyses Descriptive analysis disease exploratory Fisher’s exact test group help hospital Hospital admission hospital care Hospitalization Hospitalized identify Interpretation Intervention knowledge monitoring Most patient Most patients multiplicity number of symptom objective observational study outcome measure participant Patient Practitioner practitioners predictors primary care recording recruited Result Retrospective study risk factor Risk factors SARS-CoV‑2 sensitivity tests setting severe disease significance level supplementary material Symptom test results was performed were assessed [DOI] 10.1007/s00508-021-01992-y PMC 바로가기 [Article Type] Observational Study
Adverse pregnancy outcomes during the COVID-19 lockdown. A descriptive studyCovid-19 Lockdown 동안 이상 임신 결과.설명 연구Research Published on 2021-11-102022-09-01 Journal: BMC Pregnancy and Childbirth [Category] MERS, 진단, [키워드] 95% CI adjusted Adverse Affect age alteration antenatal care Birth weight caused change contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cumulative death determine Effect extreme Extremely low birth weight Factor gestational age Health incidence income Infant Infants Jordan lockdown lockdowns logistic regression model Low birth weight Mortality multinomial logistic multiplicity National nationality Neonatal neonatal death Neonatal Mortality Neonates no significant difference no significant differences occurred outcome outcomes p value pandemic Perinatal death Perinatal mortality Pregnancy Preterm birth Registered Research Result Separate significantly significantly lower Spread Stillbirth study period Surveillance were used [DOI] 10.1186/s12884-021-04221-6 PMC 바로가기 [Article Type] Research
Multiplicity Eludes Peer Review: The Case of COVID-19 ResearchObservational Study Published on 2021-09-032022-10-04 Journal: International Journal of Environmental Research an [Category] SARS, 임상, [키워드] Abstract addressed arise article bypassing correlated COVID-19 Data analysis database Effect environmental research Epidemiology examined Exploratory analysis false discovery rate (FDR) health geography inferences limit measure multiple hypotheses testing multiple testing problem multiplicity observational studies P -value p -values peer peer-reviewed performed proportion reported researchers SARS-CoV-2 type I Web of Science widespread [DOI] 10.3390/ijerph18179304 PMC 바로가기 [Article Type] Observational Study
Analysis of the specificity of a COVID-19 antigen test in the Slovak mass testing program슬로바키아 대량 검사 프로그램에서 코로나19 항원 검사의 특이성 분석Research Article Published on 2021-07-292022-09-12 Journal: PLoS ONE [Category] MERS, 진단, [키워드] adjusted Antigen assumption calculate COVID-19 expected False positives knowledge lowest mass multiplicity PCR tests positive positive test result Prevalence Region Result SARS-CoV-2 SD Biosensor Slovakia specificity Standard Q tested [DOI] 10.1371/journal.pone.0255267 PMC 바로가기 [Article Type] Research Article