Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in miceRAGE 신호 전달 장애는 생쥐에서 SARS-CoV-2 감염 후 생존을 촉진하고 질병 발병을 제한합니다Research Article Published on 2022-01-252022-09-10 Journal: JCI Insight [Category] 유전자 메커니즘, 진단, [키워드] CD45 Cell cell death Cellular and molecular mechanisms contribute Critical defined disease pathogenesis driving Efficacy end products endothelial event hyperplasia immunology IMPROVE Infection Infectious disease Inflammation initiated Innate immunity interstitial pneumonia limit lung Lung injury Lungs mediator metabolic mice molecular molecular mechanism morbidity mouse model necrotic necrotic cell death outcome oxygen oxygen saturation Pathogenesis pathology perivascular perivascular inflammation populations promote RAGE receptor receptor for advanced glycation end products replicated SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection Signaling survival therapeutic target Therapeutic treatment tissue injury Treatment triggering Viral viral loads [DOI] 10.1172/jci.insight.155896 PMC 바로가기 [Article Type] Research Article
Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling PathwaysCOVID-19에서 차별적으로 발현되는 유전자의 식별 및 신호 전달 경로의 통합 생물정보학 분석Research Article Published on 2021-12-242022-09-10 Journal: Genetics Research [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis analyzed annotation bioinformatics cause CD69 cellular response chromosome complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cutoff CXCR4 cytokine cytokine production DAVID DEGs Diabetic diabetic complications Diagnosis Differentially expressed genes downregulated enrichment FN1 FoxO FOXP3 gene expression profile Gene ontology GO terms group GSEA help HLA-G hub genes identification IL-17 immune response involved ISG15 KEGG Kyoto leukocyte lung tissue mechanism MMP9 myeloid leukocyte necrotic necrotic cell death nuclear other disease pathway Pathways Pneumonia positive potential mechanisms potential molecular PPI protein-protein interaction RAGE Regulation Research screened selected signaling pathway target Treatment type I interferon upregulated Visualization [DOI] 10.1155/2021/2728757 PMC 바로가기 [Article Type] Research Article
The Role of Epithelial Damage in the Pulmonary Immune Response폐 면역 반응에서 상피 손상의 역할Review Published on 2021-10-152022-09-12 Journal: Cells [Category] MERS, SARS, 진단, [키워드] Acute inflammation cell death cell type cellular senescence Chronic diseases chronic obstructive chronic obstructive pulmonary disease (COPD) contributing to COPD coronavirus Coronavirus Disease (COVID)-19 COVID-19 damage damage-associated molecular pattern damage-associated molecular patterns (DAMPs) DAMPs disease pathogenesis dysregulation epithelial epithelial cell epithelial damage fibroblast hallmark highlight idiopathic pulmonary fibrosis (IPF) Immune cell immune response Inflammatory Injury innate immune response IPF lung necroptosis Necrosis necrotic cell death pathway promote pulmonary pulmonary disease pulmonary fibrosis Respiratory disease response responsible role senescence subsequent tissue wound healing [DOI] 10.3390/cells10102763 PMC 바로가기 [Article Type] Review
Mechanisms of troponin release into serum in cardiac injury associated with COVID-19 patientsArticle Published on 2021-07-112022-10-29 Journal: International journal of cardiology and cardiovascular diseases [Category] COVID-19, [키워드] Affect antibodies antibody cardiac troponin clinical decision co-morbidity COVID-19 COVID-19 patient COVID-19 patients Critical cTnT diabetes Elevation Evidence heart failure hypertension hypertrophic cardiomyopathy infected with SARS-CoV-2 Inflammation Injury mechanism membrane molecular mechanism myocardial injury necrotic cell death Patient Prognosis Proteins provoke SARS-CoV-2 sensitivity serum serum troponin Signaling Stratification Therapies Treatment troponin with COVID-19 [DOI] 10.46439/cardiology.1.006 PMC 바로가기 [Article Type] Article
SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell deathArticle Published on 2018-09-052022-11-01 Journal: Cell Death & Disease [Category] Coronavirus, MERS, [키워드] activate addition Apoptotic cell death autophagy caspase-1 cause clinical manifestation contributing to dysfunction Effect Factor Genes helping implicated interact lysosomal lysosomal membrane membranes molecular mechanism necrotic cell death NLRP3 inflammasome assembly nucleus occur oligomerization Open reading frame pathophysiologic pathway Pathways Potassium Protein reading SARS-CoV SARS-CoV infection severe lung pathology target TFEB Transcription translocate Trigger while [DOI] 10.1038/s41419-018-0917-y PMC 바로가기 [Article Type] Article