Atypical hemolytic uremic syndrome induced by SARS-CoV2 infection in infants with EXOSC3 mutationArticle Published on 2022-11-012022-11-16 Journal: Pediatric Nephrology (Berlin, Germany) [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Activation affected aHUS. Atypical autosomal-recessive changes in characterized complement Complication COVID-19 Degradation disease disorder dysfunction endothelial cell damage EXOSC3 EXOSC3 mutation genetic disorder Infant Infection kidney mechanism microvascular injury Mutation neurodegenerative nuclear offset Pathogenesis Patient patients rare disease reported resulting RNA RNA exosome SARS-COV-2 infection SARS-CoV2 infection severe COVID-19 the SARS-CoV-2 thrombotic Treatment triggered uremic syndrome Viral RNA [DOI] 10.1007/s00467-022-05566-6 PMC 바로가기
Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2-encoded Nsp1Article Published on 2022-10-182022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ABCE1 abort acute respiratory syndrome affecting AKT Alzheimer’s disease autophagy biochemical analysis combating condition coronavirus COVID-19 pandemic Critical disease Diseases Drosophila effective exhibited Factors Genetic Host hosts mechanism modify neurodegenerative nonstructural protein 1 nsp1 overexpression pathogenic mechanism phenotype prevention Protein Quality control quality-control rescued Research ribosome collision ribosome-associated quality control. ribosomes SARS-CoV-2 Signaling specificity therapeutic strategy translation Treatment virus [DOI] 10.1073/pnas.2202322119 PMC 바로가기
Systems Bioinformatics Reveals Possible Relationship between COVID-19 and the Development of Neurological Diseases and Neuropsychiatric DisordersArticle Published on 2022-10-162022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Acidic acute respiratory syndrome Analysis app Autoimmunity bioinformatics biological processe Combination contribute coronavirus COVID-19 development disease disease-associated disorder disorders dysregulation epitope Epitopes genetic risk factor GFAp Host identify incidence include increased risk indicated Infection linear MAPT microtubule-associated protein modulated molecular molecular mimicry motif Multiple Myasthenia network biology neurodegenerative Neurodegenerative diseases neurological Neurological disease Neurological diseases Neurological disorder Neuropsychiatric neuropsychiatric disorders PPI precursor Protein protein-protein interaction Proteins receptors recognize relationship SARS-CoV-2 SARS-CoV-2 epitope SARS-COV-2 infection sclerosis sequence similarity System systems bioinformatics. [DOI] 10.3390/v14102270 PMC 바로가기
Neuroinflammation in Dementia-Therapeutic Directions in a COVID-19 Pandemic SettingArticle Published on 2022-09-222022-11-15 Journal: Cells [Category] SARS, 진단, [키워드] activate Activation Affect cognitive complications Concentration COVID-19 cytokine production Dementia direction dysfunction Efficacy Factors Glia glial cell glial cells group of diseases heterogenous highlight human organism IL-1β immune response Inconclusive Inflammation Inflammatory Intervention molecular neurodegenerative Neuroinflammation Neuron NSAID outcome pathology peripheral pro-inflammatory signaling provide resulting risk SARS-CoV-2 setting shown Side effects therapeutic approaches TNF TNF antagonist TNF antagonists while [DOI] 10.3390/cells11192959 PMC 바로가기
SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerationsReview article Published on 2022-09-012022-10-05 Journal: Ageing research reviews [Category] COVID19(2023년), SARS, 비임상, [키워드] ACE2 angiotensin-converting enzyme 2 association Blood Brain brain fog cause caused cells cellular senescence comorbid conditions consequence Consequences coronavirus coronavirus 2 Coronavirus disease 2019 COVID COVID-19 Critical death Degradation Diseases event Ferroptosis Genome Genome instability hemorrhage hemorrhagic damage Increases individual lesion likelihood multi-organ failure neurodegenerative neurological Neurological complications Neurovascular occur organ pathology predisposition prognostic raise respiratory SARS-CoV-2 SARS-COV-2 infection senescence shown Strains Survivors systemic inflammation target therapeutic Therapeutic strategies widespread [DOI] 10.1016/j.arr.2022.101687 [Article Type] Review article
Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease용도 변경 항암 표피 성장 인자 수용체 억제제: 알츠하이머 병에서 신경 보호 효과의 메커니즘Review Published on 2022-09-012022-09-11 Journal: Neural Regen Res [Category] 비임상, [키워드] Alzheimer's disease Alzheimer’s disease animal model autophagy breath caused disease Disease progression downstream signaling pathway downstream signaling pathways drug drug re-positioning Effect effective enhancement epidermal epidermal growth factor epidermal growth factor receptor Evidence examined explained growth factor human epidermal growth factor receptor-2 kinase inhibitors mechanism modulation molecular mechanism neurodegeneration neurodegenerative Neurodegenerative diseases Neuroinflammation neurological manifestation neurological manifestations Numerous oxidative oxidative stress Perspective positioning Prospective clinical trial recent receptor receptor inhibitor Research shown signaling pathways Therapeutic approach tyrosine tyrosine kinase inhibitors [DOI] 10.4103/1673-5374.332132 PMC 바로가기 [Article Type] Review
Post-COVID-19 Parkinsonism and Parkinson’s Disease Pathogenesis: The Exosomal Cargo HypothesisArticle Published on 2022-08-282022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] accompanied acute respiratory syndrome aggregation alpha-synuclein Brain cargo cascades caused clinical manifestation clinical manifestations complex contributing to Coronavirus disease 2019 Coronavirus-2 correlation COVID-19 Diagnosis disease disease severity Dopaminergic neuron Evidence Exosome Exosomes Extracellular host protein Infection Inflammation Inflammatory Inflammatory mediators Intercellular communication long-lasting modulated molecular neurodegeneration neurodegenerative Neuroinflammation neurological Parkinson’s disease parkinsonian Parkinsonism Pathogenesis pathophysiological conditions pathway phenotype Pneumonia post-COVID-19 Post-infection prevalent promoter Protein reflected SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA similarity substantia Symptoms syndrome Transmission Viral proteins virus [DOI] 10.3390/ijms23179739 PMC 바로가기
Exploring the Impact of ACE Inhibition in Immunity and Disease면역 및 질병에 대한 ACE 억제의 영향 탐색Review Published on 2022-08-042022-09-11 Journal: Journal of the Renin-Angiotensin-Aldosterone Syste [Category] SARS, 치료기술, [키워드] ACE ACE inhibitor ACE inhibitors aldosterone Alter angiotensin Angiotensin II angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme Antibiotic resistance Antigen presentation ARBs Arthritis Autoimmune autoimmune conditions Autoimmune disease Autoimmune diseases benefit Cancer Complication contribute coronavirus Diseases elevated enzyme highlight human neutrophil human neutrophils Immune cell immune cell populations immune cells immune regulation Immunocompromise Impact implicated independent independent of Infection Inflammation inflammatory immune cell inflammatory immune cells inhibition inhibitor Lupus Macrophage macrophages malignancy neurodegenerative Neutrophils no effect outcome overactive overexpression pandemic Patient phagocytosis RAAS Renin renin-angiotensin-aldosterone system Research responses rheumatoid arthritis risk ROS SARS-CoV2 therapeutic interventions understanding wake Zinc [DOI] 10.1155/2022/9028969 PMC 바로가기 [Article Type] Review
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics Reviews Published on 2022-08-022022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 치료제, [키워드] atherosclerotic atherosclerotic lesion benefit Cancer cancers cardiovascular disease cardiovascular diseases cardiovascular event cardiovascular system Cell cholesterol cholesterol homeostasis cholesteryl esters clinics Critical CVD diabetes disease Diseases Disturbed endothelial events Health inhibiting Intervention Lipid Low-Density Lipoprotein cholesterol maintaining mechanism molecular neurodegenerative nonalcoholic fatty liver obesity Osteoporosis pathway preclinical study Prevent PROTECT Regulation regulatory pathways Research shown target Transport Treatment virus infection [DOI] 10.1038/s41392-022-01125-5 [Article Type] Reviews
COVID-19 and risk of neurodegenerative disorders: A Mendelian randomization study Research Published on 2022-07-142022-10-05 Journal: Translational Psychiatry [Category] Coronavirus, 바이오마커, 유전자 메커니즘, [키워드] alleviate Alzheimer’s disease Analysis association complications of COVID-19 conducted correlation COVID-19 Dementia demonstrated Evidence frontotemporal dementia Future Genetic Genome-wide association study higher risk Hospitalization Lewy body mendelian randomization multiple sclerosis neurodegenerative neurodegenerative disorder neurodegenerative disorders Parkinson’s disease positive risk robust Sensitivity analyses severity severity of COVID-19 significantly suggested susceptibility therapeutic intervention [DOI] 10.1038/s41398-022-02052-3 [Article Type] Research