nitric oxide – Communicable Diseases Research

Tracking peripheral vascular function for six months in young adults following SARS-CoV-2 infection

Article

Published on 2022-12-012023-07-11
Journal: Physiological Reports
[Category] COVID19(2023년),

Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise

Review article

Published on 2022-11-012022-10-05
Journal: Nitric oxide : biology and chemistry
[Category] SARS, 바이오마커, 변종, 치료제,

The favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and underlying mechanisms

Review article

Published on 2022-10-012022-10-05
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar
[Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료제,

[키워드] ACE2angiotensin converting enzyme AMP-activated protein kinase AMPKAMP-activated protein kinase angiotensin converting enzyme antigen-presenting cells antioxidant APCantigen-presenting cells c‐Jun N‐terminal kinase clinical trial Complication coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 database Direct Diseases distress Effect ERKextracellular signal-regulated kinase Evidence exhibited extracellular signal-regulated kinase Factor HBVHepatitis B virus HCVHepatitis C virus Hepatitis B virus hepatitis C virus HIVhuman immunodeficiency virus Human immunodeficiency virus IFNγinterferon γ ILInterleukin immune system Immune system dysfunction Impact indicate Inflammation Inflammatory response interferon γ interleukin involved JAKc‐Jun N‐terminal kinase Like MAPKmitogen-activated protein kinase mechanism MERS-CoVmiddle east respiratory syndrome coronavirus Middle East respiratory syndrome Coronavirus mitogen-activated protein kinase neutrophil-lymphocyte-ratio NF-κBnuclear factor kappa B nitric oxide NLRneutrophil-lymphocyte-ratio NONitric Oxide Nrf2nuclear factor erythroid 2–related factor 2 nuclear factor erythroid 2–related factor 2 nuclear factor kappa B oxidative stress pandemic pathogenesis of COVID-19 protease reactive oxygen species reducing Research ROSreactive oxygen species SARS-CoV 2severe acute respiratory syndrome coronavirus SARS-CoV-2 SARSSevere Acute Respiratory Syndrome Science searched Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus signal transducer and activation of transcription silibinin spike glycoprotein STATsignal transducer and activation of transcription T helper 1 target protein TGF-βtransforming growth factor beta Th1T helper 1 therapeutic benefits therapeutic effect therapy TLR-4toll like receptor 4 toll like receptor 4 transforming growth factor beta treating COVID-19 viral replication Web of Science WHOWorld Health Organization World Health Organization
[DOI] 10.1016/j.biopha.2022.113593 [Article Type] Review article

The role of exhaled nitric oxide (FeNO) in the evaluation of lung parenchymal involvement in COVID-19 patients

Article

Published on 2022-10-012022-11-16
Journal: Internal and Emergency Medicine
[Category] COVID19(2023년), SARS, 변종,

Sulfide regulation of cardiovascular function in health and disease

Reviews

Published on 2022-08-052022-10-05
Journal: Nature reviews. Cardiology
[Category] 바이오마커,

Serum of Post-COVID-19 Syndrome Patients with or without ME/CFS Differentially Affects Endothelial Cell Function In Vitro

ME/CFS가 있거나 없는 포스트 코로나19 증후군 환자의 혈청은 체외 내피 세포 기능에 차등적으로 영향을 미칩니다

Article

Published on 2022-08-022022-09-11
Journal: Cells
[Category] 바이오마커,

[키워드] Activation analysed Angiogenesis autoantibodies autoantibody binding Cell chronic fatigue syndrome compensatory mechanism COVID-19 Cytokines demonstrated develop Diagnostic Criteria dysregulated Effect Encephalomyelitis endothelial endothelial cells Endothelial dysfunction fatigue fatigue syndrome flow cytometry function functional groups healthy control healthy controls hypothesise in vitro investigated involved marker mechanism molecules Myalgic encephalomyelitis/chronic fatigue syndrome nitric oxide Patient patient cohort patient group patient groups patients post-COVID syndrome. profile promoted proportion reduced screened secretion sera serum serum cytokines significantly significantly increased small molecule Small molecules syndrome vascular remodelling was measured while
[DOI] 10.3390/cells11152376 PMC 바로가기 [Article Type] Article

SARS-CoV-2 accelerated clearance using a novel nitric oxide nasal spray (NONS) treatment: A randomized trial

Article

Published on 2022-08-012022-10-06
Journal: Lancet Reg Health Southeast Asia
[Category] 진단,

[키워드] 1:1 95% CI accelerate accelerated age Anti-viral treatment assessment baseline clearance clinical trial Comorbidities comparable Concentration COVID-19 COVID-19 illness defined demonstrated double-blind Endpoint evaluated funding greater greater transmissibility high risk individuals infected with SARS-CoV-2 Laboratory Limited median Mild multicentre mutate nasal Nasal spray nasal swab nitric oxide nostril parallel group Patient pharmaceutical Placebo placebo-controlled polymerase chain primary analysis population progression proportion provided Randomized randomized trial receiving reduce reverse transcription RT-PCR SARS-CoV-2 SARS-CoV-2 RNA secondary Seven study medication symptomatic the placebo group therapy Treatment treatment difference vaccination Viral load. virus virus clearance virus RNA
[DOI] 10.1016/j.lansea.2022.100036 PMC 바로가기 [Article Type] Article

On the origin of nitrosylated hemoglobin in COVID-19: Endothelial NO capture or redox conversion of nitrite?: Experimental results and a cautionary note on challenges in translational research

Short communication

Published on 2022-08-012022-10-05
Journal: Redox Biology
[Category] 치료기술,

Compassionate use of Pulmonary Vasodilators in Acute Severe Hypoxic Respiratory Failure due to COVID-19

COVID-19로 인한 급성 중증 저산소성 호흡부전에서 폐혈관 확장제의 자비로운 사용

Article

Published on 2022-08-012022-09-11
Journal: Journal of Intensive Care Medicine
[Category] COVID19(2023년), SARS, 신약개발,

[키워드] acute hypoxic respiratory failure Adult patients analysed ARDS changes in Cohort cohort of patient collected data commenced COVID-19 death Evidence failure feasible Gradient hospital hypoxaemia hypoxic respiratory failure ICU ICU admission Iloprost implementation Inhaled intensive care intensive care unit lack less median nitric oxide non-survivor Non-survivors offer outcome Oxygenation PaO Patient patients with COVID-19 patients with SARS-CoV-2 PF ratio Potential treatment Primary outcome protocol pulmonary Pulmonary vasodilators. randomised receiving reduction in respiratory Respiratory failure robust severe COVID-19 significantly study period Support survivor the median therapeutic option therapeutic options therapy trials vasodilator
[DOI] 10.1177/08850666221086521 PMC 바로가기 [Article Type] Article

Safety and practicality of high dose inhaled nitric oxide in emergency department COVID-19 patients

Randomized Controlled Trial

Published on 2022-08-012022-10-05
Journal: The American journal of emergency medicine
[Category] COVID19(2023년), SARS, 임상,

[키워드] acute respiratory symptom addition Administered administration adverse effect Asymptomatic Complete Complication control group control patient controls Coronavirus disease 2019 COVID-19 COVID-19 patient Department determine died disease Donor Emergency emergency department enrolled evaluated group High dose High-dose IMPROVE In-vitro Inhaled inhibit Intubated Measures Mild nitric oxide Nitric oxide. not significant one patient Oxygenation Patient physician Physicians positive PPM practicality Prevent prevented progression Randomized randomized clinical trial receiving Replication respiratory symptom returned Safety SARS coronavirus 2 SARS-CoV-2 selective shown single dose subject supportive care Symptoms tested Treatment treatment group Treatment outcome vascular effects viruses
[DOI] 10.1016/j.ajem.2022.04.052 PMC 바로가기 [Article Type] Randomized Controlled Trial