Immuno-informatics study identifies conserved T cell epitopes in non-structural proteins of Bluetongue virus serotypes: formulation of a computationally optimized next-generation broad-spectrum multi-epitope vaccineImmunology Original Research Published on 2024-07-012024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] Bluetongue virus serotypes conserved CD8+ and CD4+ T cell epitopes immunoinformatics in silico broad-spectrum BTV vaccine formulation non-structural proteins [DOI] 10.3389/fimmu.2024.1424307 PMC 바로가기 [Article Type] Immunology Original Research
Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseasesarticle Published on 2023-05-152024-09-05 Journal: Cell Communication and Signaling : CCS [Category] update2024, [키워드] COVID-19 non-structural proteins SARS-CoV-2 structural proteins Vaccine [DOI] 10.1186/s12964-023-01104-5 PMC 바로가기 [Article Type] article
Marine drugs as putative inhibitors against non-structural proteins of SARS-CoV-2: an in silico studyOriginal Paper Published on 2023-05-122024-09-05 Journal: Journal of molecular modeling [Category] update2024, [키워드] ADMET properties binding free energy calculations molecular docking Molecular dynamics simulation studies non-structural proteins SARS-CoV-2 [DOI] 10.1007/s00894-023-05574-9 PMC 바로가기 [Article Type] Original Paper
Targeting the vital non-structural proteins (NSP12, NSP7, NSP8 and NSP3) from SARS-CoV-2 and inhibition of RNA polymerase by natural bioactive compound naringenin as a promising drug candidate against COVID-19Article Published on 2023-04-262024-09-05 Journal: Journal of Molecular Structure [Category] update2024, [키워드] COVID-19 naringenin non-structural proteins Remdesivir RNA polymerase SARS-CoV-2 [DOI] 10.1016/j.molstruc.2023.135642 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in miceArticle Published on 2023-04-062024-09-05 Journal: bioRxiv [Category] update2024, [키워드] ADP-ribosylation coronavirus Cytokines inflammatory monocytes Innate immunity interferon macrodomain non-structural proteins SARS-CoV-2 [DOI] 10.1101/2023.04.06.535927 PMC 바로가기 [Article Type] Article
Structural insights into the activity regulation of full-length non-structural protein 1 from SARS-CoV-2Article Published on 2023-01-062024-09-05 Journal: Structure (London, England : 1993) [Category] update2024, [키워드] disordered protein domains drug targets NMR spectroscopy non-structural proteins nsp1 SARS-CoV-2 [DOI] 10.1016/j.str.2022.12.006 PMC 바로가기 [Article Type] Article
Modelling the Transitioning of SARS-CoV-2 nsp3 and nsp4 Lumenal Regions towards a More Stable State on Complex FormationArticle Published on 2022-12-312023-07-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), [키워드] AlphaFold2 Molecular dynamics simulation non-structural proteins Nsp3 nsp4 protein-protein interaction SARS-CoV-2 transmembrane proteins. [DOI] 10.3390/ijms24010720 PMC 바로가기
An outlook on potential protein targets of COVID-19 as a druggable siteArticle Published on 2022-11-012022-11-15 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] approved cause claimed clinical trial combating contagious COVID-19 COVID-19 disease Cryo-electron microscopy Delta Efficacy feature genomic help host cell host protein infecting inhibit mechanism of action MERS-CoV Mutation non-structural proteins omicron pandemic Protein Protein target proteolytic cleavage raised Repurposed drug required SARS-CoV SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 protein shown similarity spike Spike protein strain suggested the vaccine therapeutic drugs therapeutic interventions Vaccines variants of SARS-CoV-2 viral infection virus Wuhan X-ray diffraction [DOI] 10.1007/s11033-022-07724-3 PMC 바로가기
Roles and functions of SARS-CoV-2 proteins in host immune evasion숙주 면역 회피에서 SARS-CoV-2 단백질의 역할과 기능Review Published on 2022-08-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료법, [키워드] accessory protein accessory proteins activator acute respiratory syndrome acute respiratory syndrome coronavirus coronavirus described ENCODE evade Frame function functions Genome Host host immune system IFN-β IFNs immune immune evasion inhibiting interferon interferons IRF3 mechanism mechanisms NF-κB nine non-structural protein non-structural proteins nsp1 Nsp12 nsp13 nsp14 Nsp15 nsp5 NSP6 NSP8 Nsps nuclear nuclear translocation Open reading frame ORF10 ORF3b ORF6 ORF8 Orf9b Perspective Phosphorylation Protein Regulatory role SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling STAT2 STATs structural proteins suppress TBK1 Transcription type I type I and III interferons variety Viral protein Viral proteins [DOI] 10.3389/fimmu.2022.940756 PMC 바로가기 [Article Type] Review
Targeting SARS-CoV-2 endoribonuclease: a structure-based virtual screening supported by in vitro analysisSARS-CoV-2 엔도리보뉴클레아제 표적화: 체외 분석으로 지원되는 구조 기반 가상 스크리닝Article Published on 2022-08-032022-09-11 Journal: Scientific Reports [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] Analysis approach Bank binding affinity binding energy cell line Compound compounds Concentration COVID-19 database deep learning Defense Diversity docking drug Drug Bank drug candidate endoribonuclease evade FIVE followed by Hierarchical Host host defense in vitro in vivo inhibitory concentration Interaction interfere life cycle molecular non-structural protein non-structural proteins Nsp15 Precision predict protocol responsible SARS-CoV-2 screened selectivity index shown supported targeting the binding affinity therapeutic effect Viral RNA Virtual screening virus was used were used [DOI] 10.1038/s41598-022-17573-6 PMC 바로가기 [Article Type] Article