Pre-clinical evaluation of antiviral activity of nitazoxanide against SARS-CoV-2SARS-CoV-2에 대한 nitazoxanide의 항바이러스 활성의 전임상 평가Article Published on 2022-08-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] affected animal animal model antiviral activity antiviral efficacy antiviral therapy archive clinical trial Complete Concentration COVID-19 demonstrated diffusion Diseases dosage drug effective Efficacy European European Virus Archive Global Evidence evidence of France hamsters Horizon Human Human airway epithelium humans impair in vitro Infectious diseases intranasal metabolite National nitazoxanide not effective organ organs pharmacokinetic Pre-clinical research reconstructed Research SARS-CoV-2 SARS-CoV-2 virus Support supported Therapeutics tizoxanide Treatment union viral replication Wellcome Trust [DOI] 10.1016/j.ebiom.2022.104148 PMC 바로가기 [Article Type] Article
Overview of clinical outcome and therapeutic effectiveness of Favipiravir in patients with COVID-19 admitted to intensive care unit, Riyadh, Saudi Arabia사우디아라비아 리야드의 중환자실에 입원한 COVID-19 환자에 대한 Favipiravir의 임상 결과 및 치료 효과 개요Article Published on 2022-04-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 임상, 진단, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome age analyzed antivirals approved ARDS BMI body mass body mass index Chloroquine Clinical outcome collected Comorbidities Comorbidity complications conducted control group Corticosteroid cough COVID-19 COVID-19 patient COVID-19 vaccine Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine Cytokine storm diabetes Diabetes Mellitus effective Effectiveness Efficacy Efficacy and safety enrolled enzyme Favipiravir Fever FIVE FVP group had no heart disease hospital hypertension ICU ICUs IMPROVE inhibit intensive care intensive care unit intensive care units ischemic heart disease Kingdom majority male management medications not effective other treatment other treatments overall mortality P-value pandemic Patient patients with COVID-19 Potential treatment Randomized Research respiratory distress Respiratory distress syndrome retrospective cohort study RNA RNA polymerase Saudi Arabia severe acute respiratory distress syndrome severe symptoms Shortness of breath statistically significant Symptom syndrome the cytokine storm the disease the mean therapeutic therapeutic efficacy therapy Tocilizumab two groups Viral viral infection viral infections viral replication with COVID-19 [DOI] 10.1016/j.jiph.2022.01.013 PMC 바로가기 [Article Type] Article
Global COVID-19 Vaccine Inequity: Failures in the First Year of Distribution and Potential Solutions for the Future글로벌 코로나19 백신 불평등: 유통 첫 해의 실패와 미래를 위한 잠재적 솔루션Article Published on 2022-03-072022-09-11 Journal: Frontiers in Public Health [Category] SARS, 변종, [키워드] Affect approach benefit country COVAX COVID-19 COVID-19 vaccine COVID-19 vaccines D develop distribution effective European country facilitate failure Future global pandemic Health Organization herd immunity Host Immunity include inequality intellectual property interface International international cooperation Investment knowledge majority manufacturing—R& not effective pandemic Pharmaceutical Company pharmaceutical industry Potential pricing resulting risk SARS-CoV-2 pandemic solution Support Technology transfer the SARS-CoV-2 transfer vaccination rate vaccination rates Vaccine Vaccines variant World Health Organization Year [DOI] 10.3389/fpubh.2022.821117 PMC 바로가기 [Article Type] Article
Immunogenicity and tolerability of COVID-19 messenger RNA vaccines in primary immunodeficiency patients with functional B-cell defects기능적 B 세포 결함이 있는 원발성 면역결핍 환자에서 코로나19 메신저 RNA 백신의 면역원성과 내약성Multicenter Study Published on 2022-03-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] ACE2 ACE2 blocking antibody ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody deficiency Antibody Response Antibody responses B-cell blocking activity blocking antibody BNT162b2 BNT162b2 vaccine cellular immunity Clinical management cohort of patient common variable immunodeficiency coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mRNA Vaccination COVID-19 vaccine trials detectable dose effective Efficacy enzyme evaluated functional Good Good syndrome help humoral Humoral response humoral responses IFN-γ IgG antibody IgG responses immune responses immunodeficiency immunogenicity information less mAb Messenger RNA Moderna mRNA mRNA vaccine mRNA vaccines mRNA-1273 neutralization not effective Patient patients Pfizer-BioNTech PID PIDs positive Primary immunodeficiencies Primary Immunodeficiency RBD RBD binding RBD-specific IgG responses Reactions reactogenicity Receptor binding domain referred to respiratory retrospective retrospective review Safe SARS-CoV-2 SARS-CoV-2 IFN-γ release assay SARS-CoV-2 spike protein SARS-CoV-2 spike protein antibody SARS-CoV-2 spike protein receptor binding domain SARS-CoV-2 vaccination severe acute respiratory syndrome Coronavirus Spike protein spike protein RBD stimulated subject subjects T-cell immune response T-cell Response the spike protein Tolerability vaccination Vaccine was performed were excluded with COVID-19 [DOI] 10.1016/j.jaci.2021.11.022 PMC 바로가기 [Article Type] Multicenter Study
Compressed Deep Learning to Classify Arrhythmia in an Embedded Wearable Device임베디드 웨어러블 기기에서 부정맥을 분류하기 위한 압축 딥 러닝Article Published on 2022-02-242022-09-10 Journal: Sensors (Basel, Switzerland) [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] Accuracy applied arrhythmia Asymptomatic asymptomatic patient Atrial fibrillation automatic detection can not Care compressed deep learning COVID-19 decrease deep deep learning Device Diagnosis diagnostic ECG effective embedded wearable device flash memory heart failure Hospitalization Korea University learning Medical care memory Mobilenet not effective Patient Registered reported Resnet SAME AS sampling rate stroke TensorFlow Topic unique [DOI] 10.3390/s22051776 PMC 바로가기 [Article Type] Article
A prospective evaluation of the clinical safety and effectiveness of a COVID-19 Urgent Eyecare Service across five areas in England영국의 5개 지역에 걸친 COVID-19 긴급 안과 서비스의 임상 안전성 및 효과에 대한 전향적 평가Article Published on 2022-01-012022-09-11 Journal: Ophthalmic & physiological optics : the journal of [Category] SARS, 치료기술, [키워드] Analysis Care condition Corneal corneal ulcer COVID-19 COVID-19 Urgent Eye Care Service CUES Data collection detect detrimental East effective Effectiveness England Evidence example eye eye care Eye problem false-positives FIVE floater floaters Fundus examination Guidance Harrogate hospital hypertension IMPROVE in some Intracranial Hypertension lesions macular degeneration MECS not effective oedema ophthalmology Optometrist optometry Pathologies pathology Patient patient safety presenting problem problems Regression regression analysis required resolved Retinal detachment scleritis service socio-economic status socioeconomic status stroke Symptom uptake Uveitis [DOI] 10.1111/opo.12916 PMC 바로가기 [Article Type] Article
Cold traps as reliable devices for quantitative determination of SARS-CoV-2 load in aerosols에어로졸 내 SARS-CoV-2 부하의 정량적 측정을 위한 신뢰할 수 있는 장치로서의 콜드 트랩Article Published on 2021-11-082022-09-11 Journal: Environmental Monitoring and Assessment [Category] MERS, SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus aerosol Aerosols Algorithm area of interest can be used carrier carriers Cold collected Concentration Contamination coronavirus COVID-19 detect determined by Early detection effective eliminated handling hazards help hotspot identify Indoor hotspots Isolation MALL nasal New new SARS-CoV-2 not effective Occurrence outbreak PCR pharyngeal mucosa positioned Public places Quantitative quantitative determination quantitative real time PCR reached real time real time PCR respiratory SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 testing SARS-CoV-2 variants School Schools Spread Spreading kinetics supplementary material Surveillance swabs today Transmissibility Transmission variant Ventilation Viral viral mutation viral presence virus were recorded zone [DOI] 10.1007/s10661-021-09580-3 PMC 바로가기 [Article Type] Article
Do we need bamlanivimab? Is etesevimab a key to treating Covid-19?밤라니비맙이 필요한가요? 에테세비맙이 코로나19 치료의 핵심인가?Article Published on 2021-11-012022-09-11 Journal: Expert opinion on biological therapy [Category] MERS, SARS, 변종, 진단, [키워드] 24 hour 24 hours approach approval Area bamlanivimab benefit Beta BLAZE-1 clinical trial COVID-19 COVID-19 illness critical appraisal death delta variant Effect effective etesevimab expert FDA Hospitalization information Medicine Medicines Mild mild to moderate moderate monoclonal antibodies monoclonal antibody neutralizing monoclonal antibodies not effective occurred pandemic participant Phase 3 phase 3 clinical trial. placebo group Primary outcome producing required risk factor SARS-CoV-2 subject tested the placebo group variant [DOI] 10.1080/14712598.2021.1985458 PMC 바로가기 [Article Type] Article
Efficacy of chloroquine and hydroxychloroquine in treating COVID-19 infection: A meta-review of systematic reviews and an updated meta-analysisCOVID-19 감염 치료에서 클로로퀸과 하이드록시클로로퀸의 효능: 체계적인 리뷰의 메타 리뷰 및 업데이트된 메타 분석Review Published on 2021-09-012022-09-11 Journal: Travel medicine and infectious disease [Category] Coronavirus, SARS, 신약개발, 치료제, [키워드] 95%CI Adverse adverse event adverse events association Azithromycin carried Chloroquine COVID-19 database disease Disease worsening drug effective Efficacy Efficacy and safety Evidence finding forest plot forest plots HCQ high risk Hydroxychloroquine ICU increased the risk intensive care investigated meta-analyses Meta-analysis Mortality not effective Occurrence outcome PROSPERO reducing mortality reported synthesised systematic review systematic reviews treat treating COVID-19 viral clearance virological cure Virological cure. was used [DOI] 10.1016/j.tmaid.2021.102135 PMC 바로가기 [Article Type] Review
The effect of propolis plus Hyoscyamus niger L. methanolic extract on clinical symptoms in patients with acute respiratory syndrome suspected to COVID-19: A clinical trialCOVID-19로 의심되는 급성 호흡기 증후군 환자의 임상 증상에 대한 프로 폴리스 + 하이시 아미스 니제르 L. 메탄올 추출물의 효과 : 임상 시험Randomized Controlled Trial Published on 2021-07-012022-08-31 Journal: Phytotherapy research : PTR [Category] 임상, 치료제, [키워드] abdominal pain acute respiratory syndrome Administered administration Antiviral treatment caused chest pain clinical symptom Clinical symptoms clinical trial conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease diarrhea disease Dizziness dry cough Effect effective evaluate the effect Fever groups headache Health Health crisis Hyoscyamus niger Hyoscyamus niger L. Intervention Iran Medical Sciences nausea nausea and vomiting not effective outbreak Patient patients with COVID-19 Placebo placebo group Propolis randomized clinical trial reduced referred to Shortness of breath Signs and symptoms sore throat supportive care symptomatic symptoms of COVID-19 syrup the placebo group treating COVID-19 Treatment two group two groups vomiting [DOI] 10.1002/ptr.7116 PMC 바로가기 [Article Type] Randomized Controlled Trial