Identification of genomic determinants contributing to cytokine release in immunotherapies and human diseases면역 요법 및 인간 질병에서 사이토카인 방출에 기여하는 게놈 결정인자의 식별Article Published on 2022-07-282022-09-11 Journal: Journal of Translational Medicine [Category] Coronavirus, 유전자 메커니즘, [키워드] abrogate Analysis Autoimmune diseases CAR CAR T-cell therapy CD22 cells cellular Cohort cohorts collected contribute contributing to CRS cytokine release Cytokine release syndrome dataset determinant develop driving drugs targeting expression Frequency genomic Glycolysis human disease identification immune system Immunotherapy IMPROVE in vivo Infection Influenza influenza infection influenza infections lupus erythematosus management mRNA not increased occur outcomes pathway Patient patients with influenza PFKFB4 PFKFB4. platform Prevent reaction reduce RNA extraction severity SLE syndrome systemic lupus erythematosus T-cell T-cells targeted therapy therapy tissues Treatment Tumor upregulated was used were used while with COVID-19 [DOI] 10.1186/s12967-022-03531-3 PMC 바로가기 [Article Type] Article
Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and -neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseasesSARS-CoV-2, Zika 및 Mycoplasma 전염병의 산모-태아 및 신생아 상호작용 중 바이러스 및 세균 감염의 병태생리학적 및 분자적 고려Article Published on 2022-01-012022-09-11 Journal: Biochimica et biophysica acta. Molecular basis of [Category] MERS, SARS, 바이오마커, 진단, [키워드] addition Admission age Anomaly Bacteria Bacterial infection Bacterial infections birth defects Case report case reports Case series caused cellular Characteristics children COVID-19 COVID-19 disease death disease disease severity during pregnancy elevated epidemiological data epidemiological studies Epidemiological study example fetus focus higher risk Hospitalized increase increased risk Infant Infants Infection Infectious disease intensive care intensive care unit admission Interaction macroscopic manifestation Maternal Maternal-fetal interphase mechanical ventilation mechanism microcephaly molecular mother Mycoplasma Neonate Neonates nonpregnant not increased Older outcomes pandemic Particular pathogen Pathogens pathophysiological physiological change Physiological changes Pregnancy pregnant women progression risk SARS-CoV-2 SARS-CoV-2 virus severe COVID-19 disease susceptibility susceptibility to infection susceptible the SARS-CoV-2 virus Viral virus infection viruses with COVID-19 women Zika Zika virus infection ZIKV [DOI] 10.1016/j.bbadis.2021.166285 PMC 바로가기 [Article Type] Article
First-Trimester SARS-CoV-2 Infection: Clinical Presentation, Inflammatory Markers, and Obstetric Outcomes임신 초기 SARS-CoV-2 감염: 임상 발표, 염증 표지자 및 산과적 결과Multicenter Study Published on 2022-01-012022-09-11 Journal: Fetal diagnosis and therapy [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Asymptomatic blood count clinical Complication complications coronavirus COVID-19 Doppler evaluated ferritin first trimester growth factor IL-6 increased risk Infection infections Inflammatory Inflammatory marker inflammatory markers lymphopenia Mild multicenter multicenter study not increased Obstetric Obstetric outcomes outcome performed plasma protein positive preeclampsia Pregnancy presentation Prevalence respiratory SARS-CoV-2 SARS-COV-2 infection second serologic testing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 symptomatic tyrosine uterine uterine artery women [DOI] 10.1159/000523974 PMC 바로가기 [Article Type] Multicenter Study
Results of the COVID-19 mental health international for the general population (COMET-G) studyCOVID-19 국제 정신 건강 국제 일반 인구(COMET-G) 연구 결과Article Published on 2022-01-012022-09-11 Journal: European neuropsychopharmacology : the journal of [Category] SARS, 치료기술, [키워드] Algorithm ANOVA Anxiety bipolar Bipolar disorder calculated Chi-square chi-square tests Conspiracy theories country COVID-19 COVID-19 pandemic cut-off Depression Descriptive statistics Deterioration develop disorder distress Effect Factor female Final Future General population highest International Intervention Linear regression analysis male material Mental Mental disorder Mental Disorders mental health moderate not increased participant Person psychiatry questionnaire relative Relative risk reported Research Result self-harm statistical analysis Suicidality tested utility variables variance [DOI] 10.1016/j.euroneuro.2021.10.004 PMC 바로가기 [Article Type] Article
Obstetrical outcomes and maternal morbidities associated with COVID-19 in pregnant women in France: A national retrospective cohort study프랑스 임산부의 Covid-19와 관련된 산과 적 결과 및 모체 이환율 : 국가 후 향적 코호트 연구Research Article Published on 2021-11-302022-09-10 Journal: PLoS Medicine [Category] MERS, SARS, 진단, 치료기술, [키워드] active smoking acute respiratory syndrome coronavirus adjusted Admission adverse outcome analyzed appear ART association associations Asymptomatic best Birth body mass body mass index can not Care Causality Cesarean section Characteristics Childbirth classification Clinical practice Cohort collected data complications conception conducted controls coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 group COVID-19 pandemic database diabete diabetes Diagnosis diagnosis of COVID-19 disease distress eclampsia evaluate evaluated event favor fetal fetal distress First wave France French Frequency gestation Gestational diabetes gestational hypertension greater groups health authorities hemorrhage Hospitalization Hospitalized hypertension ICD-10 ICU increased risk Infection intensive care intensive care unit investigated knowledge less limitation Maternal maternal age morbidity Mortality multiple pregnancy multivariable logistic regression multivariable logistic regression model National Non-COVID-19 non-COVID-19 group not different not increased not significantly different obesity Obstetric offered Older Older age outcome outcomes pandemic parity Patient Placenta placenta praevia Population populations postpartum hemorrhage preeclampsia pregnancies Pregnancy pregnant pregnant women Preterm birth primiparity PROTECT raise Rate recommendation recorded reproductive researcher respiratory Result Retrospective analysis retrospective cohort study Retrospective study risk Risk factors SARS-CoV-2 second trimester severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 smoking Spread statistical analysis System thromboembolic Treatment vaccination venous thromboembolic with COVID-19 women [DOI] 10.1371/journal.pmed.1003857 PMC 바로가기 [Article Type] Research Article
Community‐based differentiated service delivery models incorporating multi‐month dispensing of antiretroviral treatment for newly stable people living with HIV receiving single annual clinical visits: a pooled analysis of two cluster‐randomized trials in southern Africa매년 단일 임상 방문을 받는 HIV에 감염된 새로 안정된 사람들을 위한 항레트로바이러스 치료의 수개월 분배를 통합하는 지역 사회 기반의 차별화된 서비스 제공 모델: 남아프리카의 2건의 클러스터 무작위 시험에 대한 통합 분석Meta-Analysis Published on 2021-10-282022-09-10 Journal: Journal of the International AIDS Society [Category] MERS, SARS, 임상, 치료제, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted Analysis antiretroviral antiretroviral treatment ARMS ART CAG Care Clinic visits clinical cluster‐randomized trial Clustering Community conducted coronavirus country COVID‐19 decrease differentiated service delivery Effectiveness enrolled enrolment Evidence exposure to Frequency group Health healthcare healthcare facility HIV treatment incidence rate include Intervention intervention arms limit margin multi‐month dispensing not increased operational research participant Primary outcome provided rate ratio receiving regression analysis respiratory Result retained retention risk risk difference risk ratio secondary outcome Secondary outcomes severe acute respiratory syndrome Coronavirus SOC Treatment Trial Viral visit frequency with HIV Zimbabwe [DOI] 10.1002/jia2.25819 PMC 바로가기 [Article Type] Meta-Analysis
SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lungSARS-CoV-2는 폐에서 항응고제 및 섬유소 용해 유전자 발현을 억제합니다Research Article Published on 2021-03-082022-09-10 Journal: eLife [Category] SARS, 유전자 메커니즘, 진단, [키워드] Analysis Anticoagulant BALF Blood coagulation bronchoalvelolar Bronchoalveolar lavage fluid C1-Inhibitor circulating clearance Coagulation Coagulopathies Coagulopathy COVID-19 COVID-19 patient COVID-19 patients driver Drivers endothelial examined expression Extensive FIBRIN fibrinolysis fibrinolytic Gene Expression Human identify inflammatory disorders initiate Kinin limit Local lung Lungs molecular mechanism molecular mechanisms mRNA level mRNA levels not increased pathway Pathways promote Protein protein C receptor reduced SARS-CoV-2 significantly suppresse thrombomodulin tissue Tissue Factor transcript transcriptional profile transcriptional profiles transcripts urokinase while [DOI] 10.7554/eLife.64330 PMC 바로가기 [Article Type] Research Article
Efficacy and safety of systematic corticosteroids among severe COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials중증 코로나19 환자를 대상으로 한 전신 코르티코스테로이드의 효능 및 안전성: 무작위 대조 시험에 대한 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-02-212022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 임상, [키워드] 95% confidence interval all-cause mortality Analysis applied approach assessment benefit calculate certainty CIs Controlled controlled trials coronavirus disease Coronavirus disease 2019 Corticosteroid Corticosteroids COVID-19 COVID-19 therapy death development Disease progression Enrollment evaluate evaluated Evidence excluded extracorporeal membrane oxygenation Follow-up ICU identify Immunotherapy incidence Infectious diseases intubation Meta-analysis not increased Occurrence outcome Patient Primary outcome progression random-effects model Randomized controlled trial Randomized controlled trials RCT RCTs recovery RECOVERY trial required Result risk risk ratio searched secondary Secondary outcomes sequential analysis Serious Adverse Event Serious Adverse Events severe coronavirus disease severe COVID-19 severe COVID-19 patients subjects suggested survival systematic corticosteroid systematic review transfer Trial trial sequential analysis Ventilated Ventilation [DOI] 10.1038/s41392-021-00521-7 PMC 바로가기 [Article Type] Meta-Analysis