Efficacy and safety of azvudine in symptomatic adult COVID-19 participants who are at increased risk of progressing to critical illness: a study protocol for a multicentre randomized double-blind placebo-controlled phase III trialStudy Protocol Published on 2024-01-222024-09-05 Journal: Trials [Category] update2024, [키워드] Azvudine Disease progression Mortality Novel coronavirus infection Randomized controlled trial [DOI] 10.1186/s13063-024-07914-3 PMC 바로가기 [Article Type] Study Protocol
The results of thrombectomy from the arteries of the lower extremities in patients infected with SARS-CoV-2 Omicron variant with different severity of respiratory failureOriginal Article Published on 2023-03-032024-09-05 Journal: Vascular [Category] update2024, [키워드] acute lower limb ischemia artificial lung ventilation Coagulopathy coronavirus COVID-19 Endotheliitis lower limb artery thrombosis Novel coronavirus Novel coronavirus infection Respiratory failure SARS-CoV-2 thrombosis [DOI] 10.1177/17085381231160933 PMC 바로가기 [Article Type] Original Article
COVID-19 related vascular complications in a pediatric patient: A case reportCase report Published on 2022-10-012022-10-05 Journal: Radiology Case Reports [Category] 진단, 치료기술, [키워드] “cytokine storm” Ageusia Anosmia Atypical Case report caused classical Complication concerning COVID-19 COVID-19 complications COVID-19 vasculitis dry cough Dyspnea elevated endothelial Fever global pandemic healthy include increasingly Infection Inflammatory marker inflammatory mediator inquiry Invasion Laboratory test large vessel male Manifestations Neurological complication NEURORADIOLOGY Novel coronavirus infection pathophysiology pediatric Pediatric neuroradiology positive presenting radiological Rash Respiratory disease SARS-COV-2 infection Seizure shown subsequent Testing the disease the SARS-CoV-2 virus Vascular Vasculitis while widespread [DOI] 10.1016/j.radcr.2022.07.051 [Article Type] Case report
Quantitative Assay of SARS-CoV-2 RNA and Level of Proinflammatory Protein Gene Transcripts in Peripheral Blood Leukocytes after a Novel Coronavirus InfectionArticle Published on 2022-10-012023-07-10 Journal: Bulletin of experimental biology and medicine [Category] COVID19(2023년), [키워드] droplet digital PCR Gene Expression Inflammation Novel coronavirus infection SARS-CoV-2 [DOI] 10.1007/s10517-022-05621-0 PMC 바로가기
Detecting COVID-19 patients via MLES-Net deep learning models from X-Ray imagesX-Ray 이미지에서 MLES-Net 딥 러닝 모델을 통해 COVID-19 환자 감지Article Published on 2022-07-302022-09-11 Journal: BMC Medical Imaging [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy Attention automatically average calculation categories category caused Characteristics chest X-ray Chest X-ray images Classifier classifiers Convolutional neural network convolutional neural network (CNN) Corona Coronavirus infection correlation COVID-19 COVID-19 patient cumulative death deep deep learning diagnose Diagnosis Dot product Efficiency enhanced experimental results Factor feature Final generate IMPROVE information initial Local Mask MLES-Net. multiple groups network network model normalized Novel coronavirus Novel coronavirus infection parameter parameters Pneumonia Prevent problems restored scaled sensation similarity Spread Variability virus Virus Disease was obtained [DOI] 10.1186/s12880-022-00861-y PMC 바로가기 [Article Type] Article
Analysis of 4 cases of children with false-positive results of novel coronavirus-specific antibody신종 코로나바이러스 특이항체 위양성 아동 4건 분석Article Published on 2022-06-282022-09-11 Journal: BMC Pediatrics [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 2019 2019-nCoV 2019-nCoV infection adopted antibodies antibody Antibody detection Capital children Children's Hospital clinical experience clinical manifestations clinical records collected colloidal gold Colloidal gold antibody detection method Coronavirus infection COVID-19 COVID-19 diagnosis detect Diagnosis epidemiological history examination process examined Factor false False-positive false-positive result gold IgG IgG antibodies IgG antibody IgM IgM/IgG interfere mass mass spectrometry nCoV novel Novel coronavirus Novel coronavirus infection nucleic acid nucleic acid test nucleic acid tests outpatient clinic Patient pediatrics plasma Protein serum Serum protein single antibody specific IgM test results tested virus nucleic acid was used Whole blood [DOI] 10.1186/s12887-022-03425-9 PMC 바로가기 [Article Type] Article
Epidemiological Features of COVID-19 in Northwest Russia in 20212021년 러시아 북서부 COVID-19의 역학적 특징Article Published on 2022-04-292022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] age Alpha Analysis assessment AT.1 variant base Beta carried changes in characteristic characterized China circulating Coronavirus infection COVID-19 COVID-19 incidence COVID-19 pandemic decrease Delta delta variant epidemiological epidemiological situation epidemiological surveillance Europe feature Federal District fluctuation fluctuations Genetic Genetic variant genetic variants global health globe Health highlight increase International Lineage lineages megacity morbidity mortality rate mortality rates Northwest Russia Novel coronavirus Novel coronavirus infection occurred omicron pandemic Pasteur Institute Phylogenetic Phylogenetic tree population density progression provided reached replaced Russia Saint Petersburg SARS-CoV-2 SARS-CoV-2 strains severe COVID-19 severity shown Spread strain Surveillance Transport vaccination variant variants variants of concern VoC Wuhan [DOI] 10.3390/v14050931 PMC 바로가기 [Article Type] Article
Repurposing drugs for treatment of SARS-CoV-2 infection: computational design insights into mechanisms of actionSARS-COV-2 감염의 치료를위한 약물 용도 : 작용 메커니즘에 대한 전산 설계 통찰력Article Published on 2022-02-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), MERS, SARS, 신약개발, 치료법, 치료제, [키워드] accelerate binding site Broad Institute caused ChEMBL Compound Computational drug Coronavirus infection COVID-19 COVID-19 pandemic database deaths determine develop drug Drug development Drug repurposing feature Features health emergency help human population identify in vitro in vitro data in vivo inhibit inhibitors inhibitors of SARS-CoV-2 Interaction life Ligand mechanism molecules negatively affected non-structural proteins Novel coronavirus Novel coronavirus infection nucleocapsid nucleocapsid protein pharmacophore predicted progressed Protein Protein binding Protein target protein targets repurposing Research SARS-CoV-2 SARS-CoV-2 genome screened the SARS-CoV-2 genome therapeutic intervention therapeutic interventions Treatment Viral Viral protein Viral proteins Virtual screening virus Visualisation was used [DOI] 10.1080/07391102.2020.1825232 PMC 바로가기 [Article Type] Article
Novel Coronavirus Infection (COVID-19) Related Thrombotic and Bleeding Complications in Critically Ill Patients: Experience from an Academic Medical CenterArticle Published on 2021-11-302022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Admission age anticoagulation association baseline characteristics bleeding bleeding event bleeding mortality center clinically coagulation parameter Coagulation parameters Cohort Comorbidity Complication complications convalescent serum COVID-19 COVID-19 patient COVID-19 patients COVID19 Critically ill described died dose event experience ICU Ill incidence INR intensive care unit intermediate dose Intubated IQR major bleeding major bleeding event majority male mechanical ventilation median median age Median BMI Mortality novel Novel coronavirus infection outcome P -value Patient patients Platelet Prophylactic question raised Remdesivir retrospective risk SARS-CoV-2 secondary Sex significantly statistically significant Steroids subject suffered therapeutic anticoagulation thrombosis thrombotic thrombotic event Thrombus Treatment was performed [DOI] 10.3390/jcm10235652 PMC 바로가기 [Article Type] Article
Neurokinin-1 Receptor as a potential drug target for COVID-19 treatmentCOVID-19 치료를 위한 잠재적인 약물 표적으로서의 뉴로키닌-1 수용체Review Published on 2021-11-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 신약개발, 치료법, 치료제, [키워드] alleviate antagonist aprepitant biomedical scientist boost Brainstem clinical Clinical studies conducted Coronavirus infection Coronavirus treatment COVID-19 COVID-19 infection Cytokine storm Dexamethasone directions disease drug drug target Economy etiology hour immune system Infection Infectious disease Inflammation Neurokinin-1 Receptor antagonist neuromodulator neurotransmitter nociception novel Novel coronavirus Novel coronavirus infection pandemic Perspective receptor antagonist released respiratory Respiratory illness responsible substance substance P Substance P/ Neurokinin-1 Receptor antagonist. Symptom the disease therapeutic intervention Treatment Treatment strategies treatment strategy trigeminal nerve [DOI] 10.1016/j.biopha.2021.112159 PMC 바로가기 [Article Type] Review