Ganoderma adspersum (Ganodermataceae): Investigation of Its Secondary Metabolites and the Antioxidant, Antimicrobial, and Cytotoxic Potential of Its ExtractsArticle Published on 2023-12-302024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] cytotoxicity Ganoderma adspersum in silico lanostane-type acids nuclear receptor sterols [DOI] 10.3390/ijms25010516 PMC 바로가기 [Article Type] Article
PPAR Ligands Induce Antiviral Effects Targeting Perturbed Lipid Metabolism during SARS-CoV-2, HCV, and HCMV InfectionReview Published on 2022-01-112022-10-28 Journal: Biology [Category] COVID-19, [키워드] acting agonist amino acids analyzed antagonist antiviral drug Compound coronavirus coronavirus disease demonstrated Effect fatty acids Glucose HCMV HCV hepatitis C virus Host identify in viral Infection infections Ligand Lipid lipid metabolism mechanism metabolism Modification novel molecule nuclear receptor Nuclear receptors nucleotides organism outcome pandemic PPAR Research researcher SARS-CoV-2 simple targeting viral infection viral infections virus [DOI] 10.3390/biology11010114 PMC 바로가기 [Article Type] Review
Nuclear receptors: from molecular mechanisms to therapeuticsEndocrinology Published on 2021-11-262022-10-31 Journal: Essays in Biochemistry [Category] Coronavirus, SARS, [키워드] accelerated activated Brain Cancer cardiovascular disease COVID-19 defined disease Diseases dysregulated Endocrine endocrinology function Human inactivated knowledge mechanism molecular mechanism nuclear receptor Nuclear receptors prostate cancers receptors regulate Signaling Small molecules Standard-of-care Steroids Structure therapeutic targets Therapeutics therapy transcription factor translated various inflammatory diseases [DOI] 10.1042/EBC20210020 PMC 바로가기 [Article Type] Endocrinology
TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restrictionTMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다Research Article Published on 2021-11-222022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 유전자 메커니즘, [키워드] acquisition Activation Antiviral Antiviral effect antiviral effects ATPase biological significance Cell cell surface characterized cleavage coactivator concomitant use consequence coronavirus Critical cytoplasmic dysregulation ectopic expression Effect effector endocytic Endosomal acidification epithelial cells evade furin furin cleavage furin cleavage site gene knockout HCoV HCoV-229E HCoV-NL63 highly pathogenic Host immune response host immune responses IFN IFN treatment IFNs immune responses Inborn errors Infection infections inhibit inhibit SARS-CoV-2 inhibited inhibitor innate immune response innate immune responses interact interferon interferons ISG ISGs isoform lentivirus less Lung epithelial cells lysosomal protease mechanism MERS MERS-CoV NCOA7 NL63 nuclear nuclear receptor option overexpression Particle pathway patients with COVID-19 plasma membrane polybasic promote protease Protein pseudotyped Pseudotyped viruses receptor removal repertoire Research RNA robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike seasonal severe COVID-19 spike Spike protein Support the interferon TMPRSS TMPRSS2 TMPRSS2 protease Trigger vacuolar Vesicle Viral viral spike protein virus virus entry virus infection virus infections viruses [DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article
Vitamin D signaling inhibits HBV activity by directly targeting the HBV core promoterResearch Article Published on 2021-09-232023-06-03 Journal: The Journal of Biological Chemistry [Category] B형 간염, [키워드] 6-FAM, 6-carboxyfluorescein antiviral agent Cell signaling CHB, chronic HBV ChIP, chromatin immunoprecipitation DR, direct repeat Gene regulation HBeAg, hepatitis B “e” antigen HBsAg, hepatitis B surface antigen HBV core promoter HBV, hepatitis B virus HCC, hepatocellular carcinoma Hepatitis B virus IVT, in vitro translated NR, nuclear receptor NTCP, sodium taurocholate cotransporting polypeptide nuclear receptor pcRNA, precore RNA pgRNA, pregenomic RNA qPCR, quantitative PCR RXR, retinoid X receptor VDR, vitamin D receptor VDRE, vitamin D response element viral transcription Vitamin D Vitamin D receptor vitamin D response element [DOI] 10.1016/j.jbc.2021.101233 PMC 바로가기 [Article Type] Research Article
Strategies to Inhibit Hepatitis B Virus at the Transcript LevelReview Published on 2021-07-092023-06-02 Journal: Viruses [Category] B형 간염, [키워드] Chronic Hepatitis B covalently closed circular DNA nuclear receptor RNA interference transcription factor transcriptional inhibitor Viral integration [DOI] 10.3390/v13071327 PMC 바로가기 [Article Type] Review
Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights27 멕시코 토착 인구의 전체 게놈 변이, 인구 통계 및 생물 의학 통찰력Clinical Trial Published on 2021-04-082022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 치료기술, [키워드] ACE2 allele frequency Analysis average block Coverage dataset demonstrated diabetes drug response effective enhancer Genetic Genome genome-wide analysis genomic genomic data genotypes group groups Haplotype Health health problems helping immune impair implementation indels individuals insulin insulin resistance involved mapped mechanisms Mexican Mexicans missense variant Native nuclear nuclear receptor nucleotide obesity pathway Personalized medicine phylogenetic analyses Phylogenetic analysis population genomics population level populations Positive selection PPARG prevalent problem promoter receptor reduce responsible SARS CoV SARS CoV-2 Sequencing single nucleotide variants Stratification variant variants Variation virus whole genome Whole genome sequencing [DOI] 10.1371/journal.pone.0249773 PMC 바로가기 [Article Type] Clinical Trial
Endocrine aspects of ACE2 regulation: RAAS, steroid hormones and SARS-CoV-2Review Published on 2020-11-012023-07-12 Journal: The Journal of endocrinology [Category] SARS, [키워드] ACE2 angiotensin Corticosteroid COVID-19 Dexamethasone Glucocorticoid receptor nuclear receptor SARS-CoV-2 [DOI] 10.1530/JOE-20-0260 [Article Type] Review
The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism핵 수용체 LXR은 세포 NAD 대사에 영향을 미치는 메커니즘을 통해 숙주 대식세포의 세균 감염을 제한합니다.Article Published on 2017-01-312024-08-21 Journal: Cell Reports [Category] 살모넬라증, [키워드] Bacterial infection CD38 cytoskeleton LXR Macrophage NAD nuclear receptor