Mechanistic insights into the C-type lectin receptor CLEC12A-mediated immune recognition of monosodium urate crystalResearch Article Published on 2024-02-162024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] C-type lectin receptor CLEC12A crystal structure damage-associated molecular pattern monosodium urate crystal oligomerization phagocytic vesicle single-molecule force spectroscopy [DOI] 10.1016/j.jbc.2024.105765 PMC 바로가기 [Article Type] Research Article
Differences in Oligomerization of the SARS-CoV-2 Envelope Protein, Poliovirus VP4, and HIV VpuArticle Published on 2023-08-202024-09-05 Journal: bioRxiv [Category] update2024, [키워드] HIV Vpu native mass spectrometry oligomerization polio VP4 SARS-CoV-2 Envelope protein viroporins [DOI] 10.1101/2023.08.18.553902 PMC 바로가기 [Article Type] Article
The Cytoplasmic Domain of the SARS-CoV-2 Envelope Protein Assembles into a β-Sheet Bundle in Lipid BilayersResearch Article Published on 2023-01-202024-09-05 Journal: Journal of Molecular Biology [Category] update2024, [키워드] membrane curvature oligomerization solid-state NMR Structure determination viroporin [DOI] 10.1016/j.jmb.2023.167966 PMC 바로가기 [Article Type] Research Article
Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease VariantsArticle Published on 2022-10-302022-11-16 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, [키워드] Affect Analysis analyzed biochemically bioinformatics catalytic caused changed characterization characterized cleavage Combination conserved coronavirus Coronaviruses Course COVID-19 pandemic domain drug design effort endoribonuclease endoribonuclease. EndoU evade Evolution facilitate Genome help Host immune response in vivo inactive increase in innate immune response middle monomeric Mutation N-terminal nonstructural proteins novel coronavirus SARS-CoV-2 Nsp15 oligomerization pandemic Patient prevalent Protein residue RNA SARS-CoV-2 SARS-CoV-2 sequence Sequencing Transcription triggering understanding variant viral genome Viral protein viral replication virus wild type [DOI] 10.1016/j.jmb.2022.167796 PMC 바로가기
Biophysical Modeling of SARS-CoV-2 Assembly: Genome Condensation and BuddingArticle Published on 2022-09-202022-11-16 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] assembly budding caused cellular condensation coronavirus 2 COVID-19 pandemic curtail de novo develop drug target envelope Genome genome condensation genomic RNA host cell identify Infectious virus Interaction intrinsic M protein mechanism membranes modeling molecular Mutation N protein oligomerization pathogen Protein protein intrinsic curvature. Research respiratory responsible resulting RNA SARS-CoV-2 spike structural protein structural proteins the S protein therapeutic target therapy Vaccines viral entry viral life cycle viral particle virus while [DOI] 10.3390/v14102089 PMC 바로가기
Targeting SARS-CoV-2 nucleocapsid oligomerization: Insights from molecular docking and molecular dynamics simulationsSARS-CoV-2 뉴클레오캡시드 올리고머화 표적화: 분자 도킹 및 분자 역학 시뮬레이션의 통찰력Article Published on 2022-04-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] Analysis anti-N drugs antiviral drug antiviral drugs binding binding affinity C-terminal C-terminal domain caused complex complexes Compound computational approach COVID-19 CTD distribution drug drugs effective examined filament FIVE followed by free energy free energy landscape highest binding affinity hydrogen Hydrogen bond increase indicated infect inhibitor insight MD simulation molecular molecular docking molecular dynamics Molecular dynamics simulation N protein nucleocapsid oligomerization outbreak packaged parameter PCA PDB population distribution potential mechanism potential mechanisms Protein Rapamycin Replication RMSD RMSF Sapanisertib SARS-CoV-2 nucleocapsid SARS-CoV-2 virus self-assembly Silmitasertib stability targeting the SARS-CoV-2 virus Transcription Viral protein Viral RNA virions [DOI] 10.1080/07391102.2020.1839563 PMC 바로가기 [Article Type] Article
Insights into Binding of Single-Stranded Viral RNA Template to the Replication-Transcription Complex of SARS-CoV-2 for the Priming Reaction from Molecular Dynamics Simulations분자 역학 시뮬레이션의 프라이밍 반응을 위한 SARS-CoV-2의 복제-전사 복합체에 대한 단일 가닥 바이러스 RNA 템플릿 결합에 대한 통찰력Article Published on 2022-03-152022-09-11 Journal: Biochemistry [Category] COVID19(2023년), SARS, 치료법, [키워드] bind carried complex cryo-EM structure de novo distribution Dynamics electrostatic electrostatic interactions Evidence include insight molecular molecular dynamics Nsp12 Nsp7 NSP8 nucleotide nucleotides oligomerization primer priming reaction Replication replication-transcription complex responsible RNA RNA polymerase RNA-dependent RNA polymerase RTC SARS-CoV SARS-CoV-2 secondary structure significantly Simulation single-stranded ssRNA stem-loop subunit synthesis tail Template viral genome Viral RNA viral RNAs viral transcription [DOI] 10.1021/acs.biochem.1c00755 PMC 바로가기 [Article Type] Article
SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathwayORF3a에 의해 암호화된 SARS-CoV-2 비로포린은 NLRP3 염증 경로를 유발합니다Article Published on 2022-03-012022-09-11 Journal: Virology [Category] SARS, 변종, 치료제, [키워드] activate Amino acid amino acid residue Antiviral conserved COVID-19 COVID-19 disease cytokine drug efflux epithelial cell epithelial cells expressed expression IL-1β Infection Inflammasome inflammasome activation inflammasomes Inflammatory Inflammatory response inhibitor Intervention isolate kinase maturation NEK7 NFκB NLRC4 NLRP1 NLRP3 NLRP3 inflammasome oligomerization ORF3 ORF3a pathway Potassium potassium ion priming resulting SARS-CoV-2 SARS-CoV-2 isolates severe COVID-19 disease target the SARS-CoV-2 Trigger variants of SARS-CoV-2 Viroporin. virus [DOI] 10.1016/j.virol.2022.01.003 PMC 바로가기 [Article Type] Article
Domain-specific biochemical and serological characterization of SARS-CoV-2 nucleocapsid proteinSARS-CoV-2 뉴클레오캡시드 단백질의 도메인 특이적 생화학적 및 혈청학적 특성화Article Published on 2021-12-172022-09-11 Journal: STAR protocols [Category] MERS, SARS, 진단, 치료법, 치료제, [키워드] binding biochemical Biology Biophysics clinical clinical protocol Complete deuterium electron microscopy evaluate expression Health Sciences hydrogen immunology include interferon interferon signaling life cycle mass mass spectrometry Microbiology Microscopy modulation Molecular biology negative-stain electron microscopy Nucleocapsid proteins nucleocapsids oligomerization Protein Protein Biochemistry protein expression Protein expression and purification protocol protocols purification regions reporter RNA SARS-CoV-2 life cycle SARS-CoV-2 nucleocapsid scattering Sensitivity and specificity serological serology structural biology [DOI] 10.1016/j.xpro.2021.100906 PMC 바로가기 [Article Type] Article
New insights into genetic characteristics between multiple myeloma and COVID-19: An integrative bioinformatics analysis of gene expression omnibus microarray and the cancer genome atlas data다발성 골수종과 COVID-19 사이의 유전적 특성에 대한 새로운 통찰력: 유전자 발현 옴니버스 마이크로어레이와 암 게놈 아틀라스 데이터의 통합 생물정보학 분석Comparative Study Published on 2021-12-012022-09-11 Journal: International journal of laboratory hematology [Category] SARS, 유전자 메커니즘, [키워드] 95% CI association bioinformatics Bioinformatics analysis Cancer Characteristics Cohort Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Cox regression analysis COX6C Cytochrome C cytochrome c oxidase data set DEGs differentially expressed gene Differentially expressed genes domain downregulated expression Factor Features FIVE Functional enrichment analysis Gene Expression Genetic Genome Hematological malignancy identify independent Infection Microarray Mild mild illness Multiple Multiple myeloma New NOD2 nucleotide oligomerization overall survival Patient performed Prognosis prognostic biomarker Prognostic biomarkers protein-protein interaction screened severe COVID-19 subunit survival upregulated with COVID-19 [DOI] 10.1111/ijlh.13717 PMC 바로가기 [Article Type] Comparative Study