SARS-CoV-2 fusion-inhibitory lipopeptides maintain high potency against divergent variants of concern including OmicronSARS-CoV-2 융합 억제 리포펩티드는 오미크론을 포함한 다양한 관심 변종에 대해 높은 효능을 유지합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity Alpha antiviral activity Beta broad-spectrum antiviral broad-spectrum antivirals Cell Cell fusion cell-cell fusion combating COVID-19 pandemic D614G Delta drugs effective vaccine Effective vaccines exhibited FIVE fusion inhibitor Gamma Impact Infection inhibiting inhibitor inhibitors Lambda lipopeptide maintain mutant omicron Omicron variant other variant other variants outbreak pseudovirus pseudovirus infection pseudoviruses reduced S protein S proteins SARS-CoV-2 significantly the S protein therapeutic variant variants variants of concern VoC VOCs wild-type WT virus [DOI] 10.1080/22221751.2022.2098060 PMC 바로가기 [Article Type] Article
Factors affecting SARS-CoV-2 variant distribution in military hospitals in JordanArticle Published on 2022-11-012022-11-16 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, [키워드] affecting age Analysis association Asymptomatic B.1.617.2 caused circulation COVID Delta Demographic variables distribution effort Factor Gender Genetic variant Genome greater Health help highlight hospital hospitals IMPROVE Jordan Mild moderate MONITOR Occurrence other variant outcome pandemic Prevalence SARS-CoV-2 SARS-CoV-2 variant sequence Sequencing service significantly Sublineages sustained symptom severity Symptoms vaccination variant variants viral sample viral spread [DOI] 10.1016/j.diagmicrobio.2022.115771 PMC 바로가기
Neutralizing SARS-CoV-2 Spike Antibodies against Omicron in Paired Samples after Two or Three Doses of mRNA VaccineArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] addition antibodies antibody Beta booster dose confounder COVID-19 death Delta demonstrated detect eliminated Hospitalization Immune escape mRNA mRNA vaccination mRNA vaccine neutralization neutralization activity Neutralizing neutralizing capacity Neutralizing titer omicron Omicron variant other variant protection provide reactive Sample SARS-CoV-2 SARS-CoV-2 antibody testing Seroprevalence Serum Neutralization significant increase significantly higher spike spike IgG tested the spike protein the vaccine unique utility Vaccine vaccine response variant variants of concern [DOI] 10.1128/spectrum.02046-22 PMC 바로가기
A Bivalent Omicron-Containing Booster Vaccine against Covid-19Article Published on 2022-10-062022-11-15 Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome addition Administered Alpha B.1.1.529 binding antibody Bivalent booster booster dose Booster vaccine booster vaccines coronavirus dose Effectiveness elicited Exploratory analysis geometric mean titer group Infection Interim median time mRNA-1273 mRNA-1273 booster neutralizing antibody Neutralizing antibody response occurred other variant participant Participants reactogenicity responses against RNAs Safety SARS-CoV-2 SARS-COV-2 infection Vaccine variant Wuhan-Hu-1 [DOI] 10.1056/NEJMoa2208343 PMC 바로가기
Real-life Evidence of Lower Lung Virulence in COVID-19 Inpatients Infected with SARS-CoV-2 Omicron Variant Compared to Wild-Type and Delta SARS-CoV-2 PneumoniaArticle Published on 2022-10-012022-11-16 Journal: Lung [Category] COVID19(2023년), SARS, 변종, [키워드] adult subject ambient animal model ARDS better respiratory function blood gas analysis Comorbidities consolidation COVID-19 Delta described evidence of explain hospital Hospitalization Immunity in vitro Infection Inpatient Italy less Lineage Lower lower mortality lower risk lung parenchyma observation omicron other variant Pneumonia preliminary finding replication capacity respiratory airway Respiratory failure SARS-CoV-2 severe respiratory failure Turin variants of concern virulence wild type [DOI] 10.1007/s00408-022-00566-7 PMC 바로가기
RBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challengeArticle Published on 2022-10-012022-11-15 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] amino acid change antibody B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.427 B.1.429 B.1.617.1 B.1.617.2 Beta Combination D614G mutation Delta disease severity domain E484K evaluated expressing Gamma greater highlight human-to-human transmission induce L452R Lineage lineages mice moderate mouse-adapted SARS-CoV-2 mRNA vaccine Multiple multiple mutations Mutation mutations N439K N501Y neutralization neutralized Neutralizing activity neutralizing antibody observation omicron other variant P.1 P681R pandemic PROTECT Protein pseudotyped pseudovirus reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants serum antibody T478K the S protein Transmissibility vaccination Vaccine variant variants virulent [DOI] 10.1016/j.trsl.2022.04.007 PMC 바로가기
Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?Review Published on 2022-10-012022-10-06 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE-2 analyzed Angiotensin converting enzyme-2 B.1.1.529 catastrophic circulating contagious COVID-19 COVID-19 cases COVID-19 pandemic detrimental dissemination dominant Efficacy effort Evolution explained feasible feature FIVE Genetic hazard host receptor immune evasion immunization implication include Lineage Measures mechanism Mutation omicron Omicron variant other variant pandemic pharmacological physical Population prevalent strain raise RBD reported S-protein SARS-CoV-2 South Africa spike mutation Spread Sublineages surpassed Surveillance susceptible the receptor-binding domain the spike protein United Kingdom Vaccine vaccine effectiveness variant variants variants of concern variants of SARS-CoV-2 viral entry VoC VOCs [DOI] 10.1016/j.biopha.2022.113522 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concernArticle Published on 2022-09-182022-10-06 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] absence ACE2 acute respiratory syndrome ADK antibody BA.2 BA.5 Beta BNT162b2 breadth Breakthrough infection cell line change circulating clade Clinical effect cohorts contributed convalescent convalescent sera coronavirus COVID-19 COVID-19 hospitalisation Delta development disease severity Donor donors dose foundation Future genetic difference greater humoral Humoral response IgG in vitro isolate Lineage lineages Live virus management monitoring monoclonal antibody mortality rates nafamostat nasopharyngeal sample nasopharyngeal swabs neutralisation neutralisation assay Neutralising Antibodies neutralising antibody New observation of BNT162b2 omicron Omicron BA.1 other variant pathway peak plasma potency recorded reduced reduction reduction in Research response responses SARS-CoV-2 sensitivity significantly Sotrovimab South Spread Support supported tested Testing therapeutic Therapies TMPRSS2 TMPRSS2 inhibitor Transmission utilised vaccination Vaccine variant viral lineage viral variant [DOI] 10.1016/j.ebiom.2022.104270 PMC 바로가기 [Article Type] Article
Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2Article Published on 2022-09-142022-10-06 Journal: Cell Host & Microbe [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Analysis antibodies BA.1 BA.2 BNT162b2 vaccine change COVID-19 COVID-19 pandemic D614G determinant domain driven by Evolution examined functional hinge region immune evasion Impact individual introduced MOST Mutation N-terminal neutralization omicron other variant pandemic Protein reduced SARS-CoV-2 SARS-CoV-2 variant sensitivity sera spike Spike protein susceptibility the Spike therapeutic thought Transmission variant variant evolution. [DOI] 10.1016/j.chom.2022.07.006 PMC 바로가기 [Article Type] Article
Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants감마 SARS-CoV-2에 대한 혈장 및 기억 항체 반응은 다른 변이체에 대해 제한된 교차 보호를 제공합니다Article Published on 2022-09-052022-09-11 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody Response Beta class Cohort coronavirus cross-protection Delta elicited Epitopes evade exposure to Gamma Hospitalized implication individuals infected individual infected individuals Infection infections memory memory B cell memory B cells memory response monoclonal antibodies neutralization neutralize neutralized Neutralizing activity Neutralizing antibodies neutralizing antibody omicron other variant other variants plasma provide pseudotyped pseudovirus pseudoviruses respiratory SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly lower Spike protein vaccination variant variant-specific vaccine variant-specific vaccines variants variants of concern virus viruses Wuhan Wuhan-Hu-1 [DOI] 10.1084/jem.20220367 PMC 바로가기 [Article Type] Article