BolA affects the biofilm formation ability, outer membrane permeability and virulence, thus is required for the adaptability of Salmonella enterica serotype Typhimurium to the harsh survival environmentarticle Published on 2023-09-302024-09-01 Journal: Microbiological Research [Category] 살모넬라증, [키워드] Adaptability biofilm BolA outer membrane Salmonella Typhimurium virulence [Article Type] article
Dimeric 2-Aminoimidazoles are Highly Active Adjuvants for Gram-positive Selective Antibiotics against Acinetobacter baumanniiArticle Published on 2023-04-272024-09-05 Journal: European journal of medicinal chemistry [Category] update2024, [키워드] Acinetobacter baumannii adjuvants Antibiotic resistance macrolides outer membrane [DOI] 10.1016/j.ejmech.2023.115329 PMC 바로가기 [Article Type] Article
Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2Article Published on 2022-10-162022-11-15 Journal: Communications Biology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activate antivirals Apoptosis blocked Ebola virus Extracellular glycoprotein herpes simplex virus inhibit inhibited kinase Kinase inhibitor outer membrane Phosphorylation plasma membrane promote Protein pseudotyped receptor engagement SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike protein signaling pathway subsequent target translocation triggered triggering unique vesicular stomatitis virus viral entry virus VSV [DOI] 10.1038/s42003-022-04067-4 PMC 바로가기
NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived VesiclesArticle Published on 2022-09-232022-11-16 Journal: Cells [Category] SARS, 유전자 메커니즘, [키워드] airway epithelial cells anti-apoptotic approach BCl2 BCL2 antagonist/killer caused cell death cell-free mitochondrial DNA changes co-culture co-cultured COVID-19 COVID-19 patient Effect Effects epithelial cells functional induce inhibit Inner Interaction intercellular intercellular mitochondrial transfer knockdown MCL1 mechanism membrane vesicle mitigate mitochondrial mitochondrial DNA Mortality MSC MSCs myeloid cell myeloid cell leukemia-1 nsp4 Orf9b outer membrane overexpression plasma pro-apoptotic pro-inflammatory Protein Release reversed SARS-CoV-2 SARS-CoV-2 protein screened significantly stem cell therapeutic Therapeutic approach these cell transfer Treatment tunneling nanotubes. [DOI] 10.3390/cells11192969 PMC 바로가기
Molecular mechanism of antibiotic resistance induced by mono- and twin-chained quaternary ammonium compounds단쇄 및 쌍쇄 4차 암모늄 화합물에 의한 항생제 내성의 분자 메커니즘Article Published on 2022-08-012022-09-11 Journal: The Science of the total environment [Category] 유전자 메커니즘, [키워드] accelerated Ammonium Antibiotic resistance Antibiotics BAC benzalkonium Benzalkonium chloride Cell chloride Compound Concentration contributed COVID-19 pandemic DDAC Didecyldimethylammonium Didecyldimethylammonium chloride E. coli Evolution exposure to faster FIVE inhibitory inhibitory concentration K-12 mechanism minimum molecular mechanism Multidrug resistance Mutagenesis Mutation outbreak outer membrane phenotypic Protein rifampicin risk RNA polymerase sensitivity Sequencing significantly Usage whole-genome sequencing [DOI] 10.1016/j.scitotenv.2022.155090 PMC 바로가기 [Article Type] Article
Multidrug-resistant OXA-48/CTX-M-15 Klebsiella pneumoniae cluster in a COVID-19 intensive care unit: salient lessons for infection prevention and control during the COVID-19 pandemicResearch article Published on 2022-08-012022-10-05 Journal: The Journal of hospital infection [Category] 변종, [키워드] Appropriate Carbapenemase-producing Enterobacterales Cluster Contact COVID-19 COVID-19 pandemic COVID-19 patients CPE Critical disease doffing donning Escalation finding healthcare healthcare worker hygiene ICU ICUs infection control Infection prevention Infection prevention and control intensive care intensive care patient intensive care unit Intervention isolate Klebsiella pneumoniae measure multidrug-resistant Multidrug-resistant organisms Mutation organism Organisms outbreak outer membrane pathogen Patient patients Personal protective equipment Phylogenetic polymorphism Precaution Prevent Prolonged protocol reduced SARS-CoV-2 screening swab Sequencing Sequencing analysis single nucleotide specimen Surveillance Transmission transmission of SARS-CoV-2 ward with COVID-19 [DOI] 10.1016/j.jhin.2022.05.001 [Article Type] Research article
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics녹농균(Pseudomonas aeruginosa): 병인, 독성 인자, 항생제 내성, 숙주와의 상호 작용, 기술 발전 및 새로운 치료법Review Published on 2022-06-252022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 유전자 메커니즘, [키워드] addition Antibiotic resistance Antibiotics antimicrobial autophagy Bacterial Bacterial pathogenesis bioinformatics burn wounds Cancer caused Cell signaling cGAS chronic obstructive clinically COPD COVID-19 CRISPR CRISPR-Ca cystic fibrosis Defense develop disorder drug drug resistance Drug screening effective effort Factor Factors fibrosis gram Host host defense host immune responses host-pathogen interaction immune immune responses immunodeficiency IMPROVE infect Infection infections Inflammasome Interaction intractable invasive LPS mammalian cell mechanism metabolomics molecular Non-coding RNAs opportunistic pathogen outer membrane P. aeruginosa pathogen Pathogenesis Pathways Patient platform Pseudomona Pseudomonas aeruginosa rapid progress Regulation Research scRNA-seq secretion Severe infection signaling pathways Strains therapy traits treat use of antibiotics Ventilation Vesicle virulence widespread [DOI] 10.1038/s41392-022-01056-1 PMC 바로가기 [Article Type] Review
Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells스쿠텔라레인은 RAW264.7 세포에서 NF-κB/MAPK 신호 전달 경로를 통해 LPS 유도 염증을 억제합니다Article Published on 2022-06-122022-09-11 Journal: Molecules [Category] 유전자 메커니즘, [키워드] addition Anti-inflammatory can be used Cell cells Chinese composed Compound COVID-19 Cyclooxygenase cytokine Cytokines determine diploid endotoxin ERK expression Extracellular family Gram-negative bacteria Helicase IL-1β Immune cell immune cells immune system Inflammation Inflammatory inflammatory disorder inflammatory disorders inhibit interleukin interleukin-1β involved IκBα JNK kinases lipopolysaccharide LPS LPS-induced inflammation MAPK mechanism mitogen NF-kB NF-кB nitric oxide nitric oxide synthase no effect nuclear outer membrane p65 pathway Pathways pro-inflammatory mediators proinflammatory mediators protein kinase required SARS Coronavirus SCU scutellarein scutellarein (SCU). secretion shown stimulate stimulated TNF-α Topic treat Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α was reduced western blot [DOI] 10.3390/molecules27123782 PMC 바로가기 [Article Type] Article
A randomized, double-blind phase I clinical trial of two recombinant dimeric RBD COVID-19 vaccine candidates: Safety, reactogenicity and immunogenicity2개의 재조합 이량체 RBD COVID-19 백신 후보에 대한 무작위 이중 맹검 1상 임상 시험: 안전성, 반응성 및 면역원성Clinical Trial Published on 2022-03-182022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] adjuvants adverse event anti-RBD Anti-RBD IgG association baseline candidate clinical trial Coronavirus infection COVID-19 COVID-19 vaccine COVID-19 vaccines dimeric dose doses double-blind ELISA evaluated geometric Heterologous highest homologous or heterologous homologous schedule Humoral response immunization schedule immunogenic Immunopotentiator In-vitro intensity Interaction Local Mild MOST neutralization Neutralizing Neutralizing antibodies neutralizing antibody outer membrane Panel performed Phase I Primary outcome Randomized randomly divided RBD reactogenicity receive reported Safe Safety SARS-CoV-2 second dose secondary outcome Seroconversion significantly Spike protein subject the SARS-CoV-2 three group titre toxicology two groups vaccination vaccine candidate vaccine immunogenicity Vaccines Vesicle Volunteer were used [DOI] 10.1016/j.vaccine.2022.02.029 PMC 바로가기 [Article Type] Clinical Trial
Erythro-VLPs: Anchoring SARS-CoV-2 spike proteins in erythrocyte liposomesErythro-VLPS : 적혈구 리포좀에서 SARS-COV-2 스파이크 단백질을 고정시킨다Research Article Published on 2022-03-112022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, [키워드] ACE-2 acute respiratory syndrome acute respiratory syndrome coronavirus 2 Administered anchoring angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 assays average binding BLI Blood blood cell Cell coronavirus coronavirus disease COVID-19 cytoplasmic membrane defined dose-dependent Dynamics ELISA enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays facilitate fluorescent functional insertion intravenously Liposome membranes molecular dynamics novel open outer membrane pandemic Particles platform Protein protocol red blood cell respiratory S-protein SARS-CoV-2 spike SARS-CoV-2 spike protein scattering Seroconversion severe acute respiratory syndrome Coronavirus surfactant the SARS-CoV-2 therapeutic strategy Therapeutics Trial variants virus viruses was used [DOI] 10.1371/journal.pone.0263671 PMC 바로가기 [Article Type] Research Article