Circulating multimeric immune complexes contribute to immunopathology in COVID-19Article Published on 2022-09-262022-11-15 Journal: Nature Communications [Category] SARS, 진단, 치료기술, 치료제, [키워드] activating Activation Antiviral circulating comparable contribute COVID-19 COVID-19 progression Critical detrimental disease driven by dysregulated immune response Evidence extreme FcγRs humoral identify IgG IgG response immune complex immunopathology independent Intervention Ligand mitigate paradoxical Patient patients Protective reporter robust SARS-CoV-2 severe COVID-19 SLE specific IgG antibody systemic immune dysregulation systemic lupus erythematosus triggering with mild disease [DOI] 10.1038/s41467-022-32867-z PMC 바로가기
Interferon induction, evasion, and paradoxical roles during SARS-CoV-2 infectionSARS-CoV-2 감염 시 인터페론 유도, 회피 및 역설적 역할Review Published on 2022-08-012022-09-11 Journal: Immunological reviews [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus alleviate antiviral immunity causative agent caused cell type cell types coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death deficiency disease disease severity effort evade function IFN IFN response IFNs immune immune evasion interferon interferons interferons (IFNs location mechanism outcome paradoxical pathway Pathways Protective Research responses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly supported Therapeutics Treatment treatment of COVID-19 Type type I Type I and III IFN virus while [DOI] 10.1111/imr.13113 PMC 바로가기 [Article Type] Review
When underlying biology threatens the randomization principle — initial gout flares of urate-lowering therapy Reviews Published on 2022-07-252022-10-05 Journal: Nature reviews. Rheumatology [Category] 임상, [키워드] Analysis benefit Care Characteristics clinical trials dominant Evidence excluded expected flare generate Gout increase in Inflammatory response initial measure methodological occur paradoxical participant randomization Randomized risk robust scrutiny therapy Trial [DOI] 10.1038/s41584-022-00804-5 [Article Type] Reviews
Echocardiography findings in COVID-19 patients admitted to intensive care units: a multi-national observational study (the ECHO-COVID study)Observational Study Published on 2022-06-012022-10-05 Journal: Intensive care medicine [Category] Fulltext, MERS, 임상, [키워드] acute cor pulmonale Admission admitted to ICU affected age Analysis appear cardiac cardiac function Cardiomyopathy Care clinical clinical information Cohort collected coronavirus disease COVID-19 COVID-19 patient Critically ill database develop dysfunction echocardiographic echocardiography exhibited filling pressure hospital ICU ICU admission ill patient information intensive care intensive care unit left ventricle LV systolic dysfunction male mechanical ventilation median age Mortality Older age paradoxical Patient patients positive pressure ventilation pressure overload Quantitative RV dysfunction RV systolic function septal ventricular dysfunction was performed was related while [DOI] 10.1007/s00134-022-06685-2 PMC 바로가기 [Article Type] Observational Study
Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS)코로나19 이후 증후군 및 만성 피로 증후군(ME/CFS) 환자의 내피 기능 장애 및 변경된 내피 바이오마커Article Published on 2022-03-222022-09-11 Journal: Journal of Translational Medicine [Category] MERS, SARS, 바이오마커, [키워드] ACE ACE2 age analysed angiopoietin angiotensin Angiotensin-converting enzyme association Biomarker Biomarkers blood pressure BMI chronic fatigue syndrome clinical parameter Clinical parameters cohort of patient Concentration criteria defined Diagnostic Criteria dysfunction elevated Encephalomyelitis endocan endothelial endothelial cells Endothelial dysfunction endothelial function Endotheliitis Endothelin Endothelin-1 Endothelium ET-1 Evidence exhibited fatigue fatigue syndrome FIVE HCs healthy control hyperaemia IL-8 infect investigated malaise Myalgic encephalomyelitis/chronic fatigue syndrome paradoxical Pathomechanism Patient patients peripheral positive correlation post-COVID syndrome profile reactive Reactive hyperaemia index. SARS-CoV-2 seronegative serum Sex shown significantly subgroups subset Symptom syndrome [DOI] 10.1186/s12967-022-03346-2 PMC 바로가기 [Article Type] Article
Constrictive pericarditis after SARS-CoV-2 vaccination: A case reportSARS-CoV-2 예방접종 후 협착성 심낭염: 증례 보고Case Reports Published on 2022-03-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Analysis antibody body weight cardiac catheterization cardiovascular complications Case report catheterization caused Computed tomography Constrictive pericarditis coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection CT scan Diagnosis Dyspnea echocardiography edema effort heart failure IgM and IgG indicated inspiration Interventricular septum jugular venous pressure mRNA mRNA vaccine nucleocapsid protein Nucleocapsid proteins paradoxical performed peripheral edema Ribonucleic acid SARS-CoV-2 SARS-CoV-2 spike second dose second dose of vaccine septal severe acute respiratory syndrome Coronavirus tomography vaccination Vaccine venous Venous pressure weight gain [DOI] 10.1016/j.ijid.2022.01.027 PMC 바로가기 [Article Type] Case Reports
Increased B Cell Selection Stringency In Germinal Centers Can Explain Improved COVID-19 Vaccine Efficacies With Low Dose Prime or Delayed BoostImmunology Published on 2021-11-302022-10-31 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Affinity maturation amplifying Antigen appear B cell boost Can center clinical trials complex COVID-19 COVID-19 vaccine Delayed dosage doses dosing interval Effect Effects Efficacy elicited Germinal germinal center (GC) help higher affinity IMPROVE Improved Increased lower dose memory B cell offer paradoxical predicted prime and boost prime-boost immunization prime-boost interval protocols reduced remained resulting SARS-CoV-2 selected Selection the antibody response the vaccine tuning vaccination Vaccine vaccine efficacy [DOI] 10.3389/fimmu.2021.776933 PMC 바로가기 [Article Type] Immunology
The Paradox of Conspiracy Theory: The Positive Impact of Beliefs in Conspiracy Theories on Preventive Actions and Vaccination Intentions during the COVID-19 PandemicArticle Published on 2021-11-112022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] Action addition Analysis belief belief in conspiracy theories Consequences Conspiracy theories COVID-19 COVID-19 pandemic dominant engage ENhance Government Impact indicated Intention paradox paradoxical perceived benefit positive preventive action previous study promote response theory Trust vaccination vaccination intentions [DOI] 10.3390/ijerph182211825 PMC 바로가기 [Article Type] Article
Burnout syndrome and its determinants among healthcare workers during the first wave of the Covid-19 outbreak in Italy: a cross-sectional study to identify sex-related differences이탈리아에서 코로나19 발병의 첫 번째 물결 동안 의료 종사자들 사이에서 발생한 번아웃 증후군과 그 결정 요인: 성 관련 차이를 식별하기 위한 횡단면 연구Article Published on 2021-08-262022-09-11 Journal: La Medicina del lavoro [Category] SARS, 치료기술, [키워드] association both sexes Burnout COVID-19 COVID-19 pandemic cross-sectional cross-sectional study Demand Depersonalization described determinant determinants Effect Emotional exhaustion Factors female First wave framework Future greater HCW HCWs healthcare worker Healthcare workers highlighting identify individual investigated Italy job Longitudinal analyses longitudinal analysis male males Nurse outbreak pandemic paradoxical Protective protective factor reported Resilience reveal risk risk factor Sex-related differences Stressor stressors syndrome was performed was used [DOI] 10.23749/mdl.v112i4.11316 PMC 바로가기 [Article Type] Article
Multiple simultaneous embolic cerebral infarctions 11 months after COVID-19Case Report Published on 2021-08-182022-10-29 Journal: Thrombosis Journal [Category] COVID-19, [키워드] anticoagulation Case report Coagulopathy consequence coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 illness D-dimer disease elevated emboli embolic etiology General population highlight implication Infarction initial Mild Multiple pandemic paradoxical Patient prevalent Pulmonary emboli Pulmonary embolus serious complication Shortness of breath stroke the patient Thromboembolic event Thrombolysis treated Venous Thromboembolism VTE was determined [DOI] 10.1186/s12959-021-00304-8 PMC 바로가기 [Article Type] Case Report