A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccineArticle Published on 2022-11-012022-11-15 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] activated airway epithelial cells Antigen B cell Beta Cell cross-reactive delta variant dendritic cell development domain effective elicited facilitated humoral IgA response immune response Immunity induce Inflammation intranasal long-lasting lung mice Microparticle mucosal nasal Parenteral porous prime and boost Protective RBD SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 vaccine subunit type 1 helper vaccination Vaccinations Vaccine variant Viral load [DOI] 10.1016/j.trsl.2022.06.004 PMC 바로가기
Protection against SARS-CoV-2 transmission by a parenteral prime-Intranasal boost vaccine strategyArticle Published on 2022-10-012022-11-15 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Administered airway boost Booster vaccine CAF®01 cationic clearance effective elicit elicited European evaluated HexaPro highlight Horizon IgA response immune response intranasal intranasal vaccine lower airway Lung pathology mucosal mucosal immune Neutralizing antibodies onward transmission Parenteral PROTECT protection regimen Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission Serum neutralizing antibody severe disease spike supported Transmission trimer union upper airway upper airways upper respiratory tract Vaccine virus virus transmission [DOI] 10.1016/j.ebiom.2022.104248 PMC 바로가기
Activity of ertapenem/zidebactam (WCK 6777) against problem EnterobacteralesArticle Published on 2022-09-302022-11-16 Journal: Journal of Antimicrobial Chemotherapy [Category] SARS, 비임상, [키워드] 1:1 active against activity administration breakpoint Dilution E. coli Escherichia coli evaluated experiments group healthcare increasingly indicated Infection inhibited isolate Klebsiella KPC Laboratory material MDR National nosocomial Outpatient over Parenteral pathogen Patient proportion regimen SARS-CoV-2 secondary submitted Support susceptibility Trial will drive [DOI] 10.1093/jac/dkac280 PMC 바로가기
Effect of early nutrition support on length of stay, mortality, and extubation in patients with COVID-19Observational Study Published on 2022-08-012022-10-04 Journal: Nutrition in clinical practice : official publicat [Category] 임상, [키워드] assessment banner coronavirus disease COVID-19 decrease Effect Enteral enteral nutrition extubation failure group hospital ICU Inpatient intensive care intensive care unit Intubated intubation Length of stay median Medicine Mortality Multicenter trial nutrition observé outcome outlined Parenteral Patient patients with COVID-19 Prospective released retrospective significant difference Society statistically significant statistically significant difference Support the timing with COVID-19 [DOI] 10.1002/ncp.10868 PMC 바로가기 [Article Type] Observational Study
Systemic Neutralizing Antibodies and Local Immune Responses Are Critical for the Control of SARS-CoV-2전신 중화 항체와 국소 면역 반응은 SARS-CoV-2의 통제에 중요합니다Article Published on 2022-06-102022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] administration approved Brain cell-mediated immune response complex Control Correlate of protection COVID-19 COVID-19 vaccines Critical dissemination DNA Efficacy elicited heterologous vaccine humoral humoral responses immune response immunization immunogenic intramuscular intranasal Local lung mucosal mucosal immunity nanovaccine Neutralizing Parenteral Plasmid prevented Protective reduced response SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S serum systemic T-cell immune response transgenic mice used to evaluate Vaccine viral burden viral replication [DOI] 10.3390/v14061262 PMC 바로가기 [Article Type] Article
Intravenous veterinary ivermectin in a COVID-19 patient causing neurotoxicityCase report Published on 2022-02-072022-10-05 Journal: IDCases [Category] 신약개발, [키워드] administration Concentration Confirmed COVID-19 infection Coronavirus disease 2019 COVID-19 COVID-19 patient dose Hospitalization ICU Infection intensive care intravenous Ivermectin neurotoxicity occur Parenteral Patient required safety profile Serious Adverse Event serum subcutaneous injection was determined [DOI] 10.1016/j.idcr.2022.e01446 [Article Type] Case report
Adherence to dosing schedule of denosumab therapy for osteoporosis during COVID-19 lockdown: an electronic medical record and pharmacy claims database study from AsiaCOVID-19 잠금 기간 동안 골다공증에 대한 데노수맙 요법의 투여 일정 준수: 아시아의 전자 의료 기록 및 약국 청구 데이터베이스 연구Article Published on 2022-01-012022-09-12 Journal: Osteoporosis international : a journal established [Category] MERS, SARS, 진단, [키워드] 95% CI adherence adherent analyzed Asia chronic disease Compliance conducted country COVID-19 database defined Denosumab dose electronic medical records Factor first-wave Healthcare provider hospital impacted initiated lockdown management medication men and women Osteoporosis Parenteral Parenteral. Patient performed platform quantified receive reduced retrospective second dose sensitivity analysis significantly significantly lower Singapore Singapore General Hospital therapy [DOI] 10.1007/s00198-021-06085-0 PMC 바로가기 [Article Type] Article
Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?Article Published on 2021-12-232022-10-28 Journal: Reviews in Endocrine & Metabolic Disorders [Category] COVID-19, SARS, [키워드] administration affecting appear approach bone clinical conditions condition Conference COVID-19 deficiency Diabetes Mellitus different disease Dosing Extraskeletal effects General population Glucocorticoids greater healthy indicated International International Conference kidney liver management mechanism metabolism obesity Osteoporosis outcomes parathyroid hormone Parenteral Patient populations SARS-COV-2 infection skeletal Specific syndrome therapeutic to define treated Vitamin Vitamin D vitamin D administration vitamin D level Vitamin D supplementation [DOI] 10.1007/s11154-021-09693-7 PMC 바로가기 [Article Type] Article
Effect of parenteral nutrition in oxygen escalation/de-escalation in SARS-CoV-2 infected patients who are pre-intubation: A multicenter, observational studyObservational Study Published on 2021-12-012022-10-05 Journal: Clinical nutrition ESPEN [Category] SARS, 임상, [키워드] 95% CI affected age analyzed baseline Biomarker body mass index case-control study Comorbidity control group dependent on determine Effect Escalation exacerbate Gender hospital include Initiating intravenous intubation Local malaise manifestation multicenter myalgias non-invasive ventilation outcome oxygen Oxygen requirement Oxygen requirements Parenteral parenteral nutrition Patient patients Pre-intubation risk SARS-CoV-2 SARS-CoV-2 infected patient SARS-COV-2 infection SARS-CoV-2 patient significantly significantly lower Symptom variety [DOI] 10.1016/j.clnesp.2021.10.007 PMC 바로가기 [Article Type] Observational Study
The effect of high-dose parenteral vitamin D 3 on COVID-19-related inhospital mortality in critical COVID-19 patients during intensive care unit admission: an observational cohort studyObservational Study Published on 2021-09-012022-10-05 Journal: European journal of clinical nutrition [Category] SARS, 임상, 진단, 치료기술, 치료법, [키워드] Administered administration Admission Analysis C-reactive protein Clinical course control group COVID-19 COVID-19 patient COVID-19 patients critical COVID-19 patient deficiency did not reduce High-dose Hospital stay Hospitalized ICU intensive care intramuscularly Intubated intubation Kaplan-Meier survival analysis log-rank test Mortality multivariate logistic regression Observational cohort study Parenteral parenteral administration Patient single dose survival the median the patient Vitamin D was performed [DOI] 10.1038/s41430-021-00984-5 PMC 바로가기 [Article Type] Observational Study