An Overlooked and Underrated Endemic Mycosis—Talaromycosis and the Pathogenic Fungus Talaromyces marneffeiReview Published on 2023-01-172024-09-05 Journal: Clinical Microbiology Reviews [Category] update2024, [키워드] growth biology Host immune response Infectious disease pathogenic mechanism Talaromyces marneffei Talaromycosis [DOI] 10.1128/cmr.00051-22 PMC 바로가기 [Article Type] Review
Autoimmune and inflammatory thyroid diseases following vaccination with SARS-CoV-2 vaccines: from etiopathogenesis to clinical managementArticle Published on 2022-12-012022-11-16 Journal: Endocrine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] adjuvant adverse effects age Autoimmune autoimmune thyroiditis benefit Clinical management clinician described disease Diseases Doppler Factor Fever Follow-up Genetic genetic susceptibility grave Graves’ disease homology inactivated Inflammatory inflammatory markers men molecular mRNA-based Neck pain palpitation pandemic pathogenic mechanism Patient patients patients with SARS-CoV-2 predisposition Protein reported SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 vaccination SARS-CoV-2 vaccines silent Subacute Subacute thyroiditis symptoms onset syndrome Thyroid Thyroiditis Treatment vaccination Vaccine Vaccines women [DOI] 10.1007/s12020-022-03118-4 PMC 바로가기
Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2-encoded Nsp1Article Published on 2022-10-182022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ABCE1 abort acute respiratory syndrome affecting AKT Alzheimer’s disease autophagy biochemical analysis combating condition coronavirus COVID-19 pandemic Critical disease Diseases Drosophila effective exhibited Factors Genetic Host hosts mechanism modify neurodegenerative nonstructural protein 1 nsp1 overexpression pathogenic mechanism phenotype prevention Protein Quality control quality-control rescued Research ribosome collision ribosome-associated quality control. ribosomes SARS-CoV-2 Signaling specificity therapeutic strategy translation Treatment virus [DOI] 10.1073/pnas.2202322119 PMC 바로가기
Applications of human organoids in the personalized treatment for digestive diseasesArticle Published on 2022-09-272022-11-16 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 유전자 메커니즘, [키워드] application approach build Chemotherapy Clinical treatment CRISPR-Cas9 digestive digestive system disease Diseases dose Drug screening epithelial facilitated Genetic helping highlight human physiology in vitro include Infection Intervention mechanism model system organ Organoid over pathogenic pathogenic mechanism Patient Perspective physiological Research SARS-CoV-2 targets test model therapy tissue Traditional Treatment [DOI] 10.1038/s41392-022-01194-6 PMC 바로가기
Retinal microvascular morphology versus COVID-19: What to anticipate?Research article Published on 2022-09-012022-10-05 Journal: Photodiagnosis and photodynamic therapy [Category] COVID19(2023년), SARS, 바이오마커, 변종, [키워드] age angiotensin-converting enzyme 2 complete recovery COVID-19 COVID-19 infected patient COVID-19 infection cross-sectional Diagnosis eyes Foveal avascular zone group healthy subject healthy subjects Microvascular morphology morphological change morphology no significant difference Optical coherence tomography Optical coherence tomography angiography outer retina parameter parameters pathogenic mechanism patients positive recorded Region Result Retina Retinal SARS-COV-2 infection significant changes in significant difference significantly lower subjects swab sample thrombotic vessel Vessel density [DOI] 10.1016/j.pdpdt.2022.102920 [Article Type] Research article
Single cell gene expression profiling of nasal ciliated cells reveals distinctive biological processes related to epigenetic mechanisms in patients with severe COVID-19Research article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 임상, [키워드] Activation addition analyses biological processe Cell cellular chromatin ciliated cell Clinical course COVID-19 disease DNA downregulation Epigenetic epithelial cell expand explain Gene expression profiling gene expression signature healthy control histone methylation Histones Interaction mechanism mechanisms membrane permeability Methylation miRNA misfolded proteins Mitochondria Mitochondrial function molecular nasal nasopharyngeal objective pathogenic mechanism pathway enrichment Patient patients with COVID-19 Regulation Regulatory Result reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 miRNAs scRNAseq sequence severe COVID-19 Single-cell RNA sequencing Single-cell transcriptomics the patient upregulation were used [DOI] 10.1016/j.compbiomed.2022.105895 [Article Type] Research article
Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 infection and primary Sjogren’s syndromeCOVID-19 감염 및 원발성 쇼그렌 증후군에 대한 잠재적인 일반적인 병원성 메커니즘의 생물정보학 분석Article Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] Analysis CDCA2 cellular component cellular components CMPK2 COVID-19 COVID-19 infection cytoHubba database DEGs diagnostic Diagnostic markers differentially expressed differentially expressed gene Differentially expressed genes downloaded Evidence functional annotation Gene Expression Omnibus gene expression profile Gene expression profiles gene regulatory network General population Genes GEO HERC5 hub genes Ifi44 IFI44L IFIT1 IFIT2 IFIT3 marker mechanism metabolic pathway metabolic pathways molecular mechanism molecular mechanisms MX1 participated Pathogenesis pathogenic mechanism pathway Patient performed PPI Prevalence primary Sjogren’s syndrome. progression protein-protein interaction regulatory network reveal RRM2 selected significantly higher Sjögren’s syndrome subsequent analyses syndrome TOP2A transcription factor TYMS [DOI] 10.3389/fimmu.2022.938837 PMC 바로가기 [Article Type] Article
Proteomic and Metabolomic Characterization of SARS-CoV-2-Infected Cynomolgus Macaque at Early Stage초기 단계에서 SARS-CoV-2에 감염된 Cynomolgus Macaque의 단백질체 및 대사체 특성 분석Article Published on 2022-07-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] analyzed characterization COVID-19 COVID-19 infection cynomolgus macaque cynomolgus macaques Cytokines demonstrated dysregulated early infection early stage Efficacy effort feature Features immune immune response innate immune response lung tissue lung tissues lymphopenia macaque mechanism metabolomic profiling metabolomics moderate Moderate COVID-19 neutrophilia Pathogenesis pathogenic mechanism patients platelet activation proteomic proteomics SARS-CoV-2 SARS-COV-2 infection sera severe COVID-19 severe COVID-19 patients Stage Symptom the early stage. Therapeutics tissues Vaccine weakened [DOI] 10.3389/fimmu.2022.954121 PMC 바로가기 [Article Type] Article
Does SARS-CoV-2 affect neurodegenerative disorders? TLR2, a potential receptor for SARS-CoV-2 in the CNS Reviews Published on 2022-04-082022-10-05 Journal: Experimental & Molecular Medicine [Category] COVID19(2023년), SARS, 바이오마커, [키워드] accumulating ACE2 ACE2 expression addition Affect Alzheimer’s disease binding caused Central nervous system CNS component components coronavirus COVID-19 Critical disease highlight identify infected patients Infection infiltration innate immune Interaction Lungs microbial neurodegenerative Neurological symptom pandemic Parkinson’s disease Pathogenesis pathogenic mechanism pathology patients Protein receptor recognize Respiratory system resulting SARS-CoV-2 SARS-COV-2 infection seeking shown therapy TLR2 unlikely viral entry virus [DOI] 10.1038/s12276-022-00755-7 [Article Type] Reviews
Cytokine cascade in Kawasaki disease versus Kawasaki-like syndrome가와사키병 대 가와사키 유사 증후군의 사이토카인 캐스케이드Review Published on 2022-03-252022-09-11 Journal: Physiological research [Category] SARS, 유전자 메커니즘, [키워드] acquired heart disease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Aneurysm autoantibody Autoimmunity cardiovascular complications cascade caspase caspase 3 cause caused Cell Characteristics characterized children Coronary artery coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine cytokine level Cytokine release syndrome Cytokine storm Cytokines defined Diagnosis Factor febrile FIVE Genetic heart disease hypercytokinemia Hyperinflammatory Hypothesis IFN-gamma IL-10 IL-2 IL-4 IL-6 immunothrombosis induce Infection Inflammatory Kawasaki disease Kawasaki-like syndrome medium MIS-C myocarditis occur Pathogenesis pathogenic mechanism pathophysiology pediatric PIMS protocol respiratory virus respiratory viruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus Shock susceptibility syndrome systemic inflammatory response systemic vasculitis the disease TNF-alpha Treatment triggered Vasculitis vessel [DOI] 10.33549/physiolres.934672 PMC 바로가기 [Article Type] Review