Effect of intra-nasal nitrilotriacetic acid trisodium salt in lowering elevated calcium cations and improving olfactory dysfunction in COVID-19 patientsRandomized Controlled Trial Published on 2022-09-012022-10-05 Journal: European archives of oto-rhino-laryngology : offic [Category] 임상, [키워드] Analysis Anosmia association Concentration COVID-19 COVID-19 adult patient COVID-19 patient Effect elevated enrolled functional healthy increase in intracellular calcium intranasal nasal olfactory olfactory disorders olfactory dysfunction patients worldwide Randomized controlled trial Research SARS-CoV-2 secretion selective significant decrease Smell Sodium chloride Symptom Treatment was performed [DOI] 10.1007/s00405-022-07424-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Integrative multiomics and in silico analysis revealed the role of ARHGEF1 and its screened antagonist in mild and severe COVID-19 patients통합 멀티오믹스 및 in silico 분석은 경증 및 중증 COVID-19 환자에서 ARHGEF1 및 선별된 길항제의 역할을 밝혔습니다.Article Published on 2022-03-012022-09-11 Journal: Journal of cellular biochemistry [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anticancer Antiviral ARHGEF1 association Biotechnology caused center co-expression co-expression network Compound computational tool computational tools coronavirus COVID-19 database DEGs determine differentially expressed gene Differentially expressed genes disease effective therapy ENhance enrichment expressed expression profile gene co-expression network Gene ontology group guanine identify in silico analysis In silico methods in vitro in vivo infected patients inherent Medicines messenger Messenger RNA Mild molecular molecular docking molecular dynamics MSI-DEGs nucleotide number of infected Ontology overlapping pathogenic pathway patients worldwide protein-protein interaction rapid increase required Research SARS-CoV-2 SARS-CoV-2 patients screened severe acute respiratory syndrome Coronavirus severe COVID-19 patient Severity of infection stratified target therapeutic drug therapeutic efficacy therapeutic target therapy virus [DOI] 10.1002/jcb.30213 PMC 바로가기 [Article Type] Article
Clinical Characteristics of Multisystem Inflammatory Syndrome in Adults A Systematic ReviewResearch Published on 2021-09-222022-10-29 Journal: JAMA Network Open [Category] COVID-19, SARS, [키워드] acute COVID-19 Adults age black CDC center children CINAHL clinical Clinical characteristics Coagulopathy Comorbidity Control COVID-19 described Diagnosis diarrhea died dysfunction dysregulated immune response elevated Epidemiology Fever finding global health Google had no heterogeneous Hospital stay hyperinflammation Hyperinflammatory Importance Improved index individuals Inflammation Inflammatory intensive care interquartile range involved IQR Kawasaki disease literature literature review marker median men MIS mitigate morbidity and mortality Most patient Multiorgan Multiorgan dysfunction Nursing objective occur organ system Patient patients worldwide Point positive prevention provide PsycINFO Relevance reported required Respiratory Support review SARS-CoV-2 SARS-COV-2 infection Shortness of breath Surveillance symptomatic syndrome systematic review the median Treatment World Health Organization [DOI] 10.1001/jamanetworkopen.2021.26456 PMC 바로가기 [Article Type] Research
The common risk factors for progression and mortality in COVID-19 patients: a meta-analysisCOVID-19 환자의 진행 및 사망률에 대한 일반적인 위험 요소: 메타 분석Meta-Analysis Published on 2021-08-012022-09-11 Journal: Archives of Virology [Category] MERS, SARS, 바이오마커, [키워드] affected Alanine alanine aminotransferase ALT Bacteria bilateral pneumonia Bilirubin C-reactive protein caused Cerebrovascular disease CHD Chronic kidney disease CKD clinical manifestations Cochrane Library Coinfection Comorbidities Coronary heart disease coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity creatine creatine kinase CRP CVD database death in COVID-19 Deceased defined fungi global public health global public health emergency Health Organization heart disease hemoptysis identify increased risk investigated Kidney disease Laboratory laboratory examinations lymphocyte Lymphocyte count malignancy Meta-analysis Mortality N-terminal neutrophil neutrophil count non-severe group NT-proBNP participant Patient patients patients worldwide peptide Platelet Platelet count Pneumonia progression proportion risk factor Risk factors severe group significantly higher significantly more sputum production survival group total bilirubin was performed WHO World Health Organization [DOI] 10.1007/s00705-021-05012-2 PMC 바로가기 [Article Type] Meta-Analysis
The most important biomarker associated with coagulation and inflammation among COVID-19 patientsCOVID-19 환자에서 응고 및 염증과 관련된 가장 중요한 바이오마커Review Published on 2021-07-012022-09-11 Journal: Molecular and cellular biochemistry [Category] 바이오마커, 치료제, [키워드] Abnormalities abnormality acute lung injury Biomarker caused Coagulation coagulation test Coagulopathy Complication conditions coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient COVID-19 patients Critical CRP D-dimer Disseminated intravascular coagulopathy early stage early stages elevated ferritin fibrinogen fibrinogen degradation products fibrinogen level Fibrinogen levels IL-6 Immunity Infection Inflammation inflammatory biomarkers inflammatory change inflammatory changes initial lack LDH leads Lung injury Lungs management multiorgan failure occur organ partial thromboplastin time Patient patients patients worldwide Platelet Platelet count Prophylaxis prothrombin Prothrombin time Respiratory failure severe patients significantly suggested supportive care target organ Test screening the disease thromboembolic THROMBOPLASTIN Viral virus [DOI] 10.1007/s11010-021-04122-4 PMC 바로가기 [Article Type] Review
Surgical Treatment and Outcomes of Colorectal Cancer Patients During the COVID-19 Pandemic: A National Population-based Study in EnglandOriginal Study Published on 2021-06-102022-10-28 Journal: Annals of Surgery Open [Category] COVID-19, [키워드] affected average Characteristics Colorectal Colorectal cancer COVID-19 COVID-19 pandemic creating Diagnosis dropped effective Elective England Evidence hospital hospitals increase in initial Laparoscopic surgery management Mortality National outcome pandemic Patient patients worldwide reduction in surgical surgical mortality Treatment [DOI] 10.1097/AS9.0000000000000071 PMC 바로가기 [Article Type] Original Study
Safety measures for COVID-19 do not compromise the outcomes of patients undergoing primary percutaneous coronary intervention: a single center retrospective studyCOVID-19에 대한 안전 조치는 1차 경피적 관상동맥 중재술을 받는 환자의 결과를 손상시키지 않습니다: 단일 센터 후향적 연구Article Published on 2021-05-112022-09-01 Journal: Scientific Reports [Category] SARS, 진단, [키워드] 95% CI Acute myocardial infarction advanced age age Analysis analyzed arrhythmia balloon BMI cardiac catheterization cardiac event cardiac events Cardiogenic shock Cardiology cardiovascular event Clinical data Comorbidity Complication Computed tomography conditions conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 group COVID-19 infection death demographic Demographic and clinical data Diseases equipment Follow-up Gender global pandemic group hospital Hospitalization ICU incidence Interventional cardiology Laboratory measure Measures Mortality Negative pressure no significant difference outcome Patient patients patients worldwide Percutaneous coronary intervention performed physician pulmonary computed tomography retrieved Retrospective study risk Safety measure Safety measures Shock significantly significantly shorter Signs and symptoms single center slight increase statistically surgical therapeutic treated two group two groups [DOI] 10.1038/s41598-021-89419-6 PMC 바로가기 [Article Type] Article
Long Covid-19: Proposed Primary Care Clinical Guidelines for Diagnosis and Disease ManagementReview Published on 2021-04-202022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] affected causes clinical clinical experience Clinical practice COVID-19 defined Diagnosis diagnosis of SARS-CoV-2 diagnostic differential diagnosis disease etiology Evidence Frequency guideline health systems identify Infection Long Long COVID-19 management manifestation Middle East Musculoskeletal Neuropsychiatric other coronavirus Patient patient groups patients worldwide press primary care rehabilitation releases respiratory SARS-CoV-2 Symptom syndrome [DOI] 10.3390/ijerph18084350 PMC 바로가기 [Article Type] Review
Prevalence of COVID-19 Positive Cases Diagnosed by Real time Polymerase Chain Reaction in a Tertiary Care Hospital of Nepal네팔 3차 병원에서 실시간 중합효소 연쇄반응으로 진단한 코로나19 양성 사례의 유병률Original Article Published on 2021-03-312022-09-10 Journal: JNMA: Journal of the Nepal Medical Association [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus-2 age Asymptomatic asymptomatic patient asymptomatic patients Care cause chain Chain Reaction chain reactions China collected conducted confirmation contagious Corona Corona virus cough COVID-19 cross-sectional cross-sectional study Cycle threshold value diagnosed females Fever focus health system hospital include individual Infection introduced majority male management MOST Nepal nucleic acid nucleic acid amplification nucleic acid amplification tests ORF patients worldwide polymerase chain polymerase chain reaction polymerase chain reactions positive presenting symptom presenting symptoms prevalence of COVID-19 processed reaction Reactions real-time polymerase chain reaction reported resource respiratory reverse transcriptase Reverse transcriptase polymerase chain reaction Ribonucleic acid severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sick Swab Symptom symptomatic cases Tertiary variant Viral viral gene viral genes viral ribonucleic acid virus was done [DOI] 10.31729/jnma.5992 PMC 바로가기 [Article Type] Original Article
The Impact of the COVID-19 Pandemic on Psychological Health and Insomnia among People with Chronic DiseasesArticle Published on 2021-03-142022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory syndrome age Anxiety chronic chronic disease Chronic diseases chronic obstructive concomitant disease Coronary heart disease coronavirus correlation COVID-19 demographic data Depression Diabetes Mellitus diagnosed Diagnosis disease elevated GAD-7 Gender Generalized Hashimoto’s disease Hashimoto’s disease Health Health care system heart failure higher risk hypertension Impact increased risk information Insomnia Insomnia Severity Index involved ISI Mental Odds ratio outbreak pandemic Patient patients worldwide PHQ-9 physical Poland problem provided psychological health pulmonary disease SARS-CoV-2 smoking Stress Symptom the SARS-CoV-2 [DOI] 10.3390/jcm10061206 PMC 바로가기 [Article Type] Article