Immunological investigation of a multiepitope peptide vaccine candidate based on main proteins of SARS-CoV-2 pathogenSARS-CoV-2 병원체의 주요 단백질에 기반한 다중 에피토프 펩타이드 백신 후보의 면역학적 조사Article Published on 2022-06-092022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] antigenic Cell complex cytotoxic T lymphocyte develop DNA E. coli Epitopes eukaryotic evaluated expression expression vectors granzyme granzyme B groups helper T lymphocyte Heterologous homologous IFN-γ IgG IgG2a IL-15 IL-21 IL-6 immune response immune responses Immunity immunized in silico in vitro in vivo indicated induce linear B linear B lymphocyte lymphocyte mammalian cell membrane protein mice multiepitope peptide vaccine multiepitope vaccine Multiepitope vaccines nucleocapsid Nucleocapsid phosphoprotein pathogen Pathogens pcDNA3.1 Penetrating peptide produced Protein regimen regimens SARS-CoV-2 SARS-COV-2 infection secretion significantly spike glycoprotein stimulated subcloned T lymphocyte target targets TNF-α Vaccine vaccine candidate variants were used [DOI] 10.1371/journal.pone.0268251 PMC 바로가기 [Article Type] Article
Pediatric emergency care in New York City during the COVID-19 pandemic shutdown and reopening periodsCOVID-19 전염병 폐쇄 및 재개 기간 동안 뉴욕시의 소아 응급 치료Article Published on 2022-06-012022-09-11 Journal: The American journal of emergency medicine [Category] COVID19(2023년), SARS, 변종, [키워드] affected Asthma Care Characteristics children city Community coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 pandemic cross-sectional analysis Decline declined decrease demographics diagnose Diagnosis disposition Emergency emergency department evaluated events finding Health Healthcare system increase in infections information initial Injury lockdown medical illness New York New York City pandemic Patient peaked pediatric Penetrating presenting Public public health Public Hospital relative Relative risk reported resource risk significantly higher significantly increased state of emergency the United State this system understanding United States variant Volume [DOI] 10.1016/j.ajem.2022.03.049 PMC 바로가기 [Article Type] Article
Reactivation of Herpes Simplex Keratitis on a Corneal Graft Following SARS-CoV-2 mRNA VaccinationSARS-CoV-2 mRNA 백신 접종 후 각막 이식편에서 단순 포진 각막염의 재활성화Case Reports Published on 2022-04-012022-09-11 Journal: Medical archives (Sarajevo, Bosnia and Herzegovina [Category] COVID19(2023년), SARS, 치료제, [키워드] acyclovir Antiviral Antiviral treatment artificial tears blepharitis cause caused causes colonization conjunctivitis Cornea Corneal corneal opacity COVID-19 COVID-19 vaccine COVID-19 vaccines epithelial Graft Herpe herpes herpes simplex herpes simplex keratitis herpes simplex virus herpes simplex virus type 1 herpes viruses herpetic keratitis HSV-1 include keratitis less loss of vision manifestation morbidity moxifloxacin mRNA mRNA vaccine occurred ocular Patient patients Penetrating Penetrating keratoplasty Prophylactic Reactivation receiving reported SARS-CoV-2 simplex the vaccine these viruses treated Treatment Uveitis vaccination virus vision [DOI] 10.5455/medarh.2022.76.146-148 PMC 바로가기 [Article Type] Case Reports
An Epidemic Within the Pandemic: The Rising Tide of Trauma During COVID-19Article Published on 2022-04-012023-07-07 Journal: The Journal of surgical research [Category] COVID19(2023년), [키워드] COVID-19 Gun violence High acuity Penetrating trauma [DOI] 10.1016/j.jss.2021.11.016 PMC 바로가기
The impact of the COVID-19 pandemic on the number of presentations of penetrating injuries to a UK major trauma centreOriginal Article Published on 2022-03-252022-10-30 Journal: Journal of public health (Oxford, England) [Category] Coronavirus, MERS, SARS, [키워드] change college COVID-19 pandemic Effect Emergency Care Frequency identify increase in initial Injury lockdown lockdowns National pandemic Patient Penetrating penetrating injury Primary outcome public health reduction in required Research Result Retrospective study returned trauma Violence were excluded [DOI] 10.1093/pubmed/fdab333 PMC 바로가기 [Article Type] Original Article
Targeting the Interaction Between Spike Protein and Nucleocapsid Protein for Suppression and Detection of Human Coronavirus OC43인간 코로나바이러스 OC43의 억제 및 검출을 위한 스파이크 단백질과 뉴클레오캡시드 단백질 간의 상호작용 표적화Article Published on 2022-03-102022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 치료기술, 치료법, 치료제, [키워드] anti-HCoV-OC43 anti-HCoV-OC43 N antibody bait and prey C-terminal domain Cell colds conserved coronavirus detect detection ELISA fusion protein HCoV HCoV-OC43 Human human coronavirus human coronavirus OC43 in vitro Infection inhibit interact Interaction investigated MERS MERS-CoV monoclonal antibody N protein N proteins Novel coronavirus nucleocapsid nucleocapsid protein OC43 Penetrating peptide prey producing Protein protein expression Replication replication of SARS-CoV-2 reported S protein SARS-CoV-2 spike Spike protein suppression target targeting the S protein Therapeutics upper respiratory tract variants virus virus detection [DOI] 10.3389/fimmu.2022.835333 PMC 바로가기 [Article Type] Article
Trends in Violent Penetrating Injuries During the First Year of the COVID-19 PandemicResearch Published on 2022-02-082022-10-29 Journal: JAMA Network Open [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] age analyzed Black patient Boston center Characteristics Community contributed COVID-19 COVID-19 pandemic cross-sectional decrease defend demographics effort England evaluated finding Health Hispanic Hispanic patient hospital Importance incidence increase in Injury Intervention male Massachusett measure median men mitigate New objective pandemic participant Patient Penetrating per day Point presenting Prevalence Primary outcome Public Racial reduce Relevance Result Retrospective cross-sectional study setting significant increase spread of COVID-19 the epidemic trauma treated trend was performed White patient women Year [DOI] 10.1001/jamanetworkopen.2021.45708 PMC 바로가기 [Article Type] Research
Levistolide A Inhibits PEDV Replication via Inducing ROS GenerationArticle Published on 2022-01-272022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] addition Affect Antiviral antiviral activity antiviral strategy cells cellular membrane Course dose-dependent manner epidemic diarrhea ER stress Generation indicated induce Inducing inhibit inhibiting inhibitor inhibitory effect less Levistolide A NAC PEDV Penetrating Porcine epidemic diarrhea virus Protein reactive oxygen species reactive oxygen specy Replication ROS ROS production sequence stimulate strain Strains suppress variant Viral RNA virus [DOI] 10.3390/v14020258 PMC 바로가기 [Article Type] Article
Effects of the COVID-19 pandemic on pediatric trauma in Southern CaliforniaOriginal Article Published on 2021-12-012022-10-28 Journal: Pediatric surgery international [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] analyses Characteristics collected COVID-19 COVID-19 pandemic demographic demonstrated Effect examined ICU identify Injury intensive care LOS Mortality multicenter no difference not significantly different outcome pandemic Patient pediatric Pediatric patient Penetrating presenting resource Result Retrospective analysis Retrospective study single-center three group trauma trauma patients ventilator was performed [DOI] 10.1007/s00383-021-05050-6 PMC 바로가기 [Article Type] Original Article
Herpetic Keratitis Preceded by COVID-19 VaccinationCase Report Published on 2021-11-252022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] accelerated Antiviral caused clinician Corneal COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines Endotheliitis herpes simplex keratitis herpetic keratitis inactivated Inactivated vaccine keratitis latency occurred ocular pandemic Patient Penetrating receiving reported risk scarring Sinovac suggested the vaccine treated triggering Vaccine development virus [DOI] 10.3390/vaccines9121394 PMC 바로가기 [Article Type] Case Report