Microbial Natural Products with Antiviral Activities, Including Anti-SARS-CoV-2: A ReviewAnti-SARS-CoV-2를 포함한 항바이러스 활성이 있는 미생물 천연 제품: 검토Review Published on 2022-07-052022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity antiviral activity antiviral drug antiviral drugs aspulvinone aurasperone Bacterial caused Compound COVID-19 COVID-19 infection death described develop disease drug Drug discovery Evidence fungal global pandemic in vitro in vivo Including increase in Infection M pro mechanism mechanism of action microbe microbes microorganism microorganisms natural natural products penicillin produced product protease recent Research resulting review SARS-CoV-2 SARS-CoV-2 virus shown simplex Spread these compound these compounds treat Vaccine viral infections virus [DOI] 10.3390/molecules27134305 PMC 바로가기 [Article Type] Review
Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine페니실린 유도체는 친핵성 시스테인과 반응하여 SARS-CoV-2 주요 프로테아제를 억제합니다Article Published on 2022-06-092022-09-11 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] analyses Analysis Bacterial Clinical efficacy complex COVID-19 COVID-19 treatment crystallographic analyses cysteine cysteine proteases derivative Enzymes highlight inhibitor inhibitors M pro mass spectrometric mechanism nucleophilic penicillin protease reaction SARS-CoV-2 main protease Serine shown synthesis the SARS-CoV-2 Treatment [DOI] 10.1021/acs.jmedchem.1c02214 PMC 바로가기 [Article Type] Article
Impact of novel microbial secondary metabolites on the pharma industry제약 산업에 대한 새로운 미생물 2차 대사 산물의 영향Review Published on 2022-03-012022-09-11 Journal: Applied Microbiology and Biotechnology [Category] COVID19(2023년), SARS, 변종, [키워드] Alexander Fleming Antibiotic resistance Antibiotics anticancer anticancer drugs Bacteria caused Clinical practice develop Diseases drug drugs effort function fungi generate Genome Health Hypocholesterolemics immunosuppressants immunosuppressive Impact IMPROVE Infection Infectious disease Infectious diseases introduced Laboratory market metagenomics microbial Microbial natural products. microorganism microorganisms New novel offer overcome pandemic penicillin problems SARS-CoV-2 SARS-CoV-2 pandemic second second wave Secondary Metabolite significantly Smaller the SARS-CoV-2 therapeutic therapy treat Treatment variants viruses Well-being [DOI] 10.1007/s00253-022-11821-5 PMC 바로가기 [Article Type] Review
Ambient NO2 is associated with Streptococcus pneumoniae-induced pneumonia in children and increases the minimum inhibitory concentration of penicillinarticle Published on 2022-01-312024-09-01 Journal: IET nanobiotechnology [Category] 폐렴구균 감염증, [키워드] Air pollution Microbial sensitivity tests nitrogen dioxide penicillin Pneumococcal pneumonia [Article Type] article
Decoding the Penicillin Resistance of Streptococcus pneumoniae for Invasive and Noninvasive Infectionsarticle Published on 2021-07-312024-09-01 Journal: Microbial Drug Resistance [Category] 폐렴구균 감염증, [키워드] meningeal and nonmeningeal break points PBP penicillin pneumococcal resistance [Article Type] article
On Column Binding a Real-Time Biosensor for β -lactam Antibiotics Quantificationβ-락탐 항생제 정량화를 위한 실시간 바이오센서의 열결합Article Published on 2020-03-102024-07-31 Journal: Molecules [Category] 폐렴구균 감염증, [키워드] Antibiotics biosensor Bocillin FL molecular quantification penicillin penicillin-binding protein [DOI] 10.3390/molecules25051248 PMC 바로가기 [Article Type] Article
Genomic epidemiology of penicillin-non-susceptible Streptococcus pneumoniae페니실린 비감수성 폐렴구균의 유전체 역학Article Published on 2019-10-142024-07-31 Journal: Microbial Genomics [Category] 폐렴구균 감염증, [키워드] Antibiotic resistance Genomic epidemiology penicillin pneumococcus [DOI] 10.1099/mgen.0.000305 PMC 바로가기
Tetanus outbreak in a sheep flock due to ear tagging귀 태그로 인해 양 무리에서 파상풍 발생Article Published on 2018-12-132024-07-30 Journal: Veterinary Medicine and Science [Category] 파상풍, [키워드] ear tagging penicillin sheep Tetanus [DOI] 10.1002/vms3.139 PMC 바로가기
A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery박테리아 세포 신장 기계에 의한 펩티도글리칸 중합의 활성화에서 PBP2의 중심 역할Research Article Published on 2018-10-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin activate activated Activation activation pathway activities activity Analysis antibiotic Author Bacteria bacterial cell biogenesis Cell Cell elongation cell wall cell wall synthesis changes in complex complexes component conserved Control control cell crosslinking cytokinesis cytoskeletal filament cytoskeletal filaments determine disrupt enzymatic activity enzyme Enzymes Escherichia coli Evidence exhibited Genetic genetic evidence glycan glycan polymerase glycan polymerases hyperactivate identify in vitro in vivo inactivated morphogenic MreB Mutation osmotic lysis pathway PBP PBP2 PBPs penicillin penicillin-binding protein penicillin-binding proteins polymerase Prevent promote PROTECT provide remained required Rod system RodA stimulate the cell uncrosslinked variant [DOI] 10.1371/journal.pgen.1007726 PMC 바로가기 [Article Type] Research Article
The mecillinam resistome reveals a role for peptidoglycan endopeptidases in stimulating cell wall synthesis in Escherichia coli메실리남 저항체는 대장균에서 세포벽 합성을 자극하는 펩티도글리칸 엔도펩티다제의 역할을 밝힙니다Research Article Published on 2017-07-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activating Activation addition allele Analysis Antibiotics approach Bacterial bacterial cell bacterial cells Beta Beta-lactam beta-lactam antibiotics beta-lactam mecillinam biogenesis build Cell cell wall cell wall synthesis cells characterization cleave cleaving complexes comprehensive resource contrary crosslink crosslinking crosslinks dataset downstream analysis drug drug resistance E . coli effective enzyme Enzymes Escherichia coli expand generate Genetic genetic background genetic loci Genome identify implicated induction inhibit involved killing loci locus mechanism mecillinam modulating mutant mutants organism overproduction PBP2 PBPs penicillin penicillin-binding protein penicillin-binding proteins performed PG synthase PG synthesis probe promote Reasoning required resource response reveal Stress stress response subset Synthase target the cell Tn-seq Tn-Seq analysis transpeptidase utility wild-type cells [DOI] 10.1371/journal.pgen.1006934 PMC 바로가기 [Article Type] Research Article