Immune profiling of SARS-CoV-2 epitopes in asymptomatic and symptomatic pediatric and adult patientsarticle Published on 2023-02-142024-09-05 Journal: Journal of Translational Medicine [Category] update2024, [키워드] Children SARS-CoV-2 infection COVID-19 Neutralizing antibodies Peptide biomarkers peptide microarray Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) [DOI] 10.1186/s12967-023-03963-5 PMC 바로가기 [Article Type] article
High-resolution analysis of long-term serum antibodies in humans following convalescence of SARS-CoV-2 infectionSARS-CoV-2 감염 회복 후 인간의 장기 혈청 항체에 대한 고해상도 분석Article Published on 2022-05-312022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, 치료법, [키워드] Accuracy aligned Analysis antibody Antibody Response antibody tests Antibody titer Antibody titers binding site Biomarker Blood Complete contribute convalescent serum COVID-19 diagnostic Diagnostic accuracy domain dominant epitope epitope Epitopes evaluated full-length full-length spike protein high-density Human identify Immunity Infection maintenance membrane protein neutralize nucleoprotein peptide peptide microarray polyclonal antibodies polyclonal antibody Previous studies previous study proteome provide reactivity Region representing resolved response SARS-CoV-2 SARS-COV-2 infection serological serum antibodies serum antibody spike epitope spike epitopes Spike protein Viral [DOI] 10.1038/s41598-022-12032-8 PMC 바로가기 [Article Type] Article
Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals세로 방향 면역 프로파일링은 COVID-19 회복기 개인의 장기 체액성 면역을 매개하는 지배적인 에피토프를 나타냅니다Article Published on 2022-04-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antibody Antibody Response caused circulating variants concerning contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19-convalescent individual COVID-19-convalescent individuals cytokine cytokine production diagnostic disease onset dissect dominant dominant epitope early stage early stages endemic human coronavirus endemic human coronaviruses epitope Epitopes fatality feature global pandemic highly pathogenic humoral humoral immune responses Humoral immunity immune immune profiling immune response immune responses Immunity individual induce Kinetics long-term immune response long-term immune responses Longevity longitudinal longitudinal analysis mapped moderate moderate symptoms N-terminal domain Neutralizing antibodies neutralizing antibody ORF1ab path patients peptide peptide microarray performed Protein Proteins proteome proteome-wide peptide microarray. reactive respiratory responsible reveal S1 subunit S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein sequence homology sequence identity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown specific antibodies Spike protein sustained symptoms of COVID-19 the early SARS-CoV-2 the S1 subunit the SARS-CoV-2 Vaccine design Wuhan-Hu-1 [DOI] 10.1016/j.jaci.2022.01.005 PMC 바로가기 [Article Type] Article
Evaluation of Spike Protein Epitopes by Assessing the Dynamics of Humoral Immune Responses in Moderate COVID-19중간 정도의 COVID-19에서 체액 면역 반응의 역학을 평가하여 스파이크 단백질 에피토프 평가Article Published on 2022-03-182022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] AbMap acute respiratory syndrome analyses Analysis antibody binding epitope Antigen Assessing caused change Characteristics Cohort comparable Comprehensive conserved coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated Diagnosis distribution domains Dynamics ELISA enzyme-linked immunosorbent epitope genomic region homotrimer Hospitalization Hospitalized host immunity humoral humoral immune response IgG IgG antibody IgM immune immune system Immunotherapy in viral Infection information Microarray Moderate COVID-19 Novel coronavirus pandemic Patient peptide peptide microarray peptides provided random reactivity recombinant response S protein S protein epitope S proteins S1 protein SARS-CoV-2 serum sample Seven spike spike gene sequence Spike protein suggested symptom onset the S protein Vaccine development were used [DOI] 10.3389/fimmu.2022.770982 PMC 바로가기 [Article Type] Article
Inhibitor screening using microarray identifies the high capacity of neutralizing antibodies to Spike variants in SARS-CoV-2 infection and vaccination마이크로어레이를 사용한 억제제 스크리닝은 SARS-CoV-2 감염 및 백신 접종에서 스파이크 변이체에 대한 항체를 중화하는 높은 능력을 식별합니다Article Published on 2022-02-282022-09-11 Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition anti-S antibody antibody antibody diversity B.1.1.7 B.1.351 B.1.617.2 Cohort convalescent COVID-19 patient convalescent COVID-19 patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccines D614G Drug development Efficacy FIVE glass slides group help heterogeneous identify Microarray Mutation NAb titers NAbs neutralization Neutralization assay neutralize Neutralizing antibodies neutralizing antibody neutralizing effect P.1 peptide peptide microarray platform Population prevalent protective effect Protein purified reduce responsible S variant SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 spike Screening serum spike spike-ACE2 These data utility vaccination vaccinee vaccinees variant variants were assessed wild-type [DOI] 10.7150/thno.67038 PMC 바로가기 [Article Type] Article
Development of an Inactivated H7N9 Subtype Avian Influenza Serological DIVA Vaccine Using the Chimeric HA Epitope ApproachResearch Article Published on 2021-09-292023-05-31 Journal: Microbiology Spectrum [Category] Fulltext, 조류인플루엔자, [키워드] Avian influenza virus DIVA vaccine epitope H7N9 subtype peptide microarray [DOI] 10.1128/Spectrum.00687-21 PMC 바로가기 [Article Type] Research Article
Peptide microarray-based analysis of antibody responses to SARS-CoV-2 identifies unique epitopes with potential for diagnostic test developmentSARS-CoV-2에 대한 항체 반응의 펩티드 마이크로어레이 기반 분석은 진단 테스트 개발 가능성이 있는 고유한 에피토프를 식별합니다.Article Published on 2021-07-012022-09-11 Journal: European Journal of Immunology [Category] SARS, 진단, 치료법, [키워드] 229E Analysis antibody antibody cross-reactivity Antibody Response antibody tests antigens binding capture capture antigen control sample controls coronavirus COVID-19 COVID-19 patient COVID-19 patients cross-reactivity diagnostic diagnostic antibody diagnostics ELISA epitope HCoV HCoVs human coronavirus identify IgG immune protection Immunity immunodominant implication MERS Microarrays nucleocapsid OC43 Patient peptide peptide microarray peptide microarray. peptides provided Region respiratory SARS-CoV-2 SARS-CoV-2 proteome screened statistically significant strain the Spike unique while widespread [DOI] 10.1002/eji.202049101 PMC 바로가기 [Article Type] Article
Epitope-Specific Antibody Responses to a Plasmodium falciparum Subunit Vaccine Target in a Malaria-Endemic Population말라리아 유행 지역에서 플라스모디움 팔시파룸 서브유닛 백신 타겟에 대한 에피토프 특이적 항체 반응Article Published on 2021-06-012024-08-08 Journal: Nanoscale [Category] 말라리아, [키워드] circumsporozoite protein malaria peptide microarray Plasmodium falciparum [DOI] 10.1093/infdis/jiaa611 PMC 바로가기
Longitudinal Development of Antibody Responses in COVID-19 Patients of Different Severity with ELISA, Peptide, and Glycan Arrays: An Immunological Case SeriesArticle Published on 2021-04-062022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome analyzed antibody caused Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 patient development diagnostics disease ELISA enzyme epitope full proteome glycan glycan microarrays help high-mannose IgA IgG IgG and IgM IgG response IgM IgM antibody immunoglobulin A immunosorbent individual intensity Interaction longitudinal longitudinal analysis Microarray Microarrays Mild mild case moderate MONITOR monoclonal antibody Patient peptide peptide microarray peptide microarrays positive Protein proteome response SARS-CoV-2 serum Sery spike glycoprotein Spread vaccination Vaccines [DOI] 10.3390/pathogens10040438 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Proteome-Wide Analysis Revealed Significant Epitope Signatures in COVID-19 PatientsSARS-CoV-2 Proteome-Wide Analysis, COVID-19 환자에서 중요한 에피토프 서명 밝혀Clinical Trial Published on 2021-03-232022-08-13 Journal: Frontiers in Immunology [Category] SARS, 임상, 진단, [키워드] acute respiratory disease acute respiratory distress Antibody Response approach asymptomatic infection B cells causative agent China clinically coronavirus COVID-19 COVID-19 outbreak COVID-19 patient COVID-19 patients death diagnostic disease epitope epitope identification exposure to high-density Host immune response humoral immune response Humoral response humoral responses IgG immune responses International Intervention leads Longevity marker Mild outcome peptide peptide microarray Predictive prognostic proteome public health emergency respiratory distress respiratory tract infection Revealed SARS-CoV-2 screened sera severe disease severe pneumonia signature Significant understanding Viral viral infection viral infections WHO [DOI] 10.3389/fimmu.2021.629185 PMC 바로가기 [Article Type] Clinical Trial