Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein–Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model SystemArticle Published on 2023-12-212024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] circular dichroism (CD) nuclear magnetic resonance (NMR) peptidomimetics protein–protein interaction (PPI) SARS-CoV-2 [DOI] 10.3390/ijms25010166 PMC 바로가기 [Article Type] Article
Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CL pro inhibitors against SARS-CoV-2Research Paper Published on 2023-05-232024-09-05 Journal: European journal of medicinal chemistry [Category] update2024, [키워드] Benzothiazolyl ketone peptidomimetics pharmacokinetic properties SARS-CoV-2 [DOI] 10.1016/j.ejmech.2023.115512 PMC 바로가기 [Article Type] Research Paper
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determinationResearch Paper Published on 2023-03-312024-09-05 Journal: European journal of medicinal chemistry [Category] update2024, [키워드] 3C-like protease inhibitors COVID-19 crystal structure peptidomimetics Reversible covalent inhibitors SARS-CoV-2 [DOI] 10.1016/j.ejmech.2023.115311 PMC 바로가기 [Article Type] Research Paper
Peptides and peptidomimetics as a therapeutic candidate for the treatment of COVID-19: A brief reviewShort Communication Published on 2023-03-202024-09-05 Journal: Indian journal of pharmacology [Category] update2024, [키워드] COVID-19 peptides peptidomimetics [DOI] 10.4103/ijp.ijp_700_22 PMC 바로가기 [Article Type] Short Communication
Identification of a short ACE2-derived stapled peptide targeting the SARS-CoV-2 spike proteinResearch Paper Published on 2023-01-172024-09-05 Journal: European journal of medicinal chemistry [Category] update2024, [키워드] COVID-19 Infectious diseases Molecular modeling peptidomimetics protein-protein interaction Ring-closing metathesis [DOI] 10.1016/j.ejmech.2023.115118 PMC 바로가기 [Article Type] Research Paper
Harnessing the Therapeutic Potential and Biological Activity of Antiviral PeptidesArticle Published on 2022-10-192023-07-10 Journal: Chembiochem [Category] COVID19(2023년), [키워드] Antiviral agents drug design peptides peptidomimetics viruses [DOI] 10.1002/cbic.202200415
Neuropilin (NRPs) Related Pathological Conditions and Their Modulators뉴로필린(NRP) 관련 병리학적 상태 및 조절인자Review Published on 2022-07-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 addition Analysis antagonists Cancer clinical disease Community computer-aided drug design condition COVID-19 COVID-19 research Diversity foci form homologous human body in silico in silico drug design joint Last Ligand ligands modulator neuropathic neuropathic pain neuropilin neuropilins NRP1 Pain pathological pathological conditions pathological role peptidomimetics physiological receptor receptor modulator design small molecule small-molecule antagonists. splice the SARS-CoV-2 therapeutic tissue transmembrane glycoprotein variant variety vertebrates viral entry [DOI] 10.3390/ijms23158402 PMC 바로가기 [Article Type] Review
Development and Evaluation of Peptidomimetic Compounds against SARS-CoV-2 Spike Protein: An in silico and in vitro StudyArticle Published on 2022-07-012023-07-07 Journal: Molecular informatics [Category] COVID19(2023년), [키워드] COVID-19 peptidomimetics SARS-CoV-2 spike Virtual screening [DOI] 10.1002/minf.202100231 PMC 바로가기
Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory CompoundsSARS-CoV-2 3CLpro 억제제에 대한 진행 상황: SARS-CoV 3CLpro 펩티드 모방체 및 소분자 항염 화합물에서 영감Review Published on 2022-04-082022-09-11 Journal: Drug design, development and therapy [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] 3CLpro accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-inflammatory anti-inflammatory agents anti-inflammatory effect Anti-inflammatory effects Antiviral antiviral target caused Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Health inhibitor inhibitors inspiration life cycle pathophysiological peptidomimetics Progress protease protease inhibitors Protein proteinase SARS-CoV SARS-CoV-2 sequence homology Sequencing severe acute respiratory syndrome Coronavirus similarity small-molecule inhibitors. viral life cycle whole-genome sequencing [DOI] 10.2147/DDDT.S359009 PMC 바로가기 [Article Type] Review
Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-LSARS-CoV-2 주요 프로테아제(Mpro/3CLpro) 및 인간 카텝신-L에 대한 MG-132의 이중 억제 구조 및 생화학적 분석Article Published on 2021-10-292022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료제, [키워드] active site Antiviral strategies binding biochemical catalytic cathepsin Cathepsin-L conditions covalent binding covalent bond COVID-19 pandemic Cys145 cysteine docking drug design dual target inhibitor effective drugs Evidence feature group highlighting Human in silico inhibit inhibited inhibition MG-132 MPro Mpro/3CLPro multi peptidomimetics Perspective protease reducing Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease similarity Structure therapy X-ray diffraction [DOI] 10.3390/ijms222111779 PMC 바로가기 [Article Type] Article