The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
The interplay between the airway epithelium and tissue macrophages during the SARS-CoV-2 infectionArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] 3D cultures activate added Air-liquid interface air-liquid interface (ALI) airway airway epithelium Antigen presentation antiviral immune response basolateral side cell type co-culture Contact Course Culture cytokine production cytokine release demonstrated driven by epithelial epithelial cells evaluate HAE hMDM hMDMs Human airway epithelium human airway epithelium (HAE) human monocyte-derived macrophage immune response in viral infected cell Infection Innate immunity lung Macrophage macrophages phagocyte primary human airway recruitment Replication SARS-CoV-2 SARS-COV-2 infection Spread the SARS-CoV-2 tissue macrophage transfer virus virus replication [DOI] 10.3389/fimmu.2022.991991 PMC 바로가기
mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cellsArticle Published on 2022-09-072022-11-16 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] antibody antigen-presenting cells appear B cell biodistribution Cancer Cancer vaccine CD8 T cell changes in Clinical studies design-of-experiments methodology effective extrahepatic delivery histopathological Immune cell immune cell populations Immunity immunization Immunotherapy induce interferon liver LNP mechanism methodology mRNA mRNA expression non-human primate phagocyte provide response responses SARS-CoV-2 spleen stimulatory systemic T cell T cell response the vaccine Type vaccination Vaccine [DOI] 10.1016/j.ymthe.2022.07.007 PMC 바로가기
Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA VaccineArticle Published on 2022-08-232022-11-16 Journal: ACS Nano [Category] COVID19(2023년), SARS, 치료기술, [키워드] antibodies antibody association biomolecular coronas Blood BNT162b2 cell interaction cell interactions clinical impact clinically correlated COVID-19 dose elevated environmental exposure Ex vivo glycol Human human blood assay identify IgG IgM immunoglobulins increase in Lipid LNP Moderna mRNA mRNA vaccination mRNA vaccine mRNA-1273 nanoparticle Neutralizing antibody response overcome particle−immune cell interactions. PEGylated lipid nanoparticle Pfizer-BioNTech phagocyte plasma receiving SARS-CoV-2 SARS-CoV-2 vaccine significant increase significantly systemic reactogenicity the SARS-CoV-2 vaccination Vaccine [DOI] 10.1021/acsnano.2c04543 PMC 바로가기
Immunogenicity of the mRNA-1273 COVID-19 vaccine in adult patients with inborn errors of immunity선천성 면역이상이 있는 성인 환자에서 mRNA-1273 코로나19 백신의 면역원성Controlled Clinical Trial Published on 2022-06-012022-09-12 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome All participant antibodies antibody Antibody Response Antibody titer baseline binding Cellular immune response CID clinically cohorts comparable Complication complications Control coronavirus correlated COVID-19 COVID-19 vaccination COVID-19 vaccine CVID deficiencies deficiency dose first vaccination healthy controls humoral immune response Immunity immunodeficiency immunogenic immunogenicity immunosuppressive drug Inborn error inborn errors of immunity increased risk Level Mild mRNA-1273 mRNA-1273 COVID-19 vaccine multicenter Neutralizing antibodies Patient patient group patients patients with CVID phagocyte Primary immunodeficiency disorders SARS-CoV-2 second vaccination seroconversion rate T-cell T-cell Response the antibody response vaccination against COVID-19 Vaccinations were assessed X-linked agammaglobulinemia XLA [DOI] 10.1016/j.jaci.2022.04.002 PMC 바로가기 [Article Type] Controlled Clinical Trial
Drugging the efferocytosis process: concepts and opportunities Reviews Published on 2022-06-012022-10-05 Journal: Nature Reviews Drug Discovery [Category] 신약개발, 임상, [키워드] Aberration addition Anti-inflammatory apoptotic apoptotic cell Atherosclerosis Cancer cell turnover change clinical trials Efferocytosis homeostasis infections Inflammatory involved molecular occur Pathologies phagocyte phenotypic promote therapeutic intervention Volume [DOI] 10.1038/s41573-022-00470-y [Article Type] Reviews
Fermented Carica papaya and Morinda citrifolia as Perspective Food Supplements for the Treatment of Post-COVID Symptoms: Randomized Placebo-Controlled Clinical Laboratory Study코로나 이후 증상 치료를 위한 관점 식품 보충제로서의 발효 카리카 파파야 및 모린다 시트리폴리아: 무작위 위약 대조 임상 실험실 연구Randomized Controlled Trial Published on 2022-05-252022-09-11 Journal: Nutrients [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] added addition alleviate Anti-inflammatory effects antioxidant antioxidant activity ATP Carica papaya clinical clinical laboratory clinical symptom Clinical symptoms computer tomography COVID-19 disease cytokine Cytokines delta variant disease Electrocardiography expression fermented food supplements food IL-17A IL-6 IL-8 immune Laboratory leukocyte long-lasting mechanisms metabolite microbiota Moderate COVID-19 modulating Morinda citrifolia Nitrate nitrates nitrates/nitrites nitric oxide nitrite nitrites omicron oral-nasal-pharyngeal microbiota participant Patient per day performed phagocyte phagocytosis physical physical endurance placebo group placebo-controlled polymorphonuclear leukocyte post-COVID symptoms pro-inflammatory cytokines questionnaire Randomized significantly single-center Symptoms the placebo group Treatment protocol tropical variant virus were assessed [DOI] 10.3390/nu14112203 PMC 바로가기 [Article Type] Randomized Controlled Trial
E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing SPMs for long COVID-19, human clinical trials, and targeted precision nutritionReview article Published on 2022-02-012022-10-05 Journal: Seminars in Immunology [Category] 임상, [키워드] absorbance activate activating Acute inflammation acute inflammatory response adaptive apoptotic cells approach B-cells biosynthesized blood clot caused cellular response clinical study clinical trials Complete COVID-19 COVID-19 infection COVID-19 pandemic Critical defined disease Disease model docosahexaenoic acid (DHA) Eicosapentaenoic acid (EPA) EPA essential fatty acid Evidence excessive inflammation Fatty acid function functional Health homeostasis human clinical trials Human phagocytes human tissue Immune cell Inflammation Inflammatory innate immune cell Interaction International Ligand local inflammation loci lymphocyte M2 macrophages Macrophage Maresin mechanism mechanisms metabolome MS2 Neutrophils omega-3 Omega-3 polyunsaturated fatty acids organ Pathogens phagocyte physical Precision precursor Preparing Protective raised required Resolvin Specific stem cell stimulate Structure structures subset surface receptor T-cell Tandem mass spectrometry tissue regeneration unique [DOI] 10.1016/j.smim.2022.101597 [Article Type] Review article
Effects of Different Drug Therapies and COVID-19 mRNA Vaccination on Semen Quality in a Man with Ankylosing Spondylitis: A Case ReportCase Report Published on 2022-01-242022-10-30 Journal: Medicina [Category] COVID-19, SARS, [키워드] Abnormalities adverse effect Affect analysed Analysis ankylosing spondylitis Case report Celecoxib Cell Characteristics Concentration COVID-19 DNA fragmentation dose drug Effect evaluated examined flow cytometry Golimumab had no healthy incidence Inflammation light microscopy limit Man material morphology mRNA mRNA COVID-19 vaccine mRNA vaccination mRNA vaccine parameter phagocyte Pregnancy Quality reduced remained report Semen Sperm sulphasalazine TEM the patient therapy transmission electron microscopy transmission electron microscopy (TEM) Treatment vaccination white cell [DOI] 10.3390/medicina58020173 PMC 바로가기 [Article Type] Case Report
Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2스파이크 의존적 옵소닌화는 용량 의존적 식균 작용 억제와 비중화 항체가 SARS-CoV-2를 보호할 수 있음을 나타냅니다Immunology Published on 2022-01-142022-09-12 Journal: Frontiers in Immunology [Category] 진단, [키워드] in vivo model antibodies antibody Antibody binding antibody function Antibody neutralization Can Concentration convalescent patient COVID19 dependent on effective effort ENhance immune function immune mechanism Immunity Increases inhibition Interaction modulation monoclonal antibody monocyte neutralize Non-neutralizing antibodies non-neutralizing antibody opsonization outcome phagocyte phagocytosis plasma protection Protein reduce reduced SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection spike spike (S) protein spike-specific antibodies Spike-specific antibody [DOI] 10.3389/fimmu.2021.808932 PMC 바로가기 [Article Type] Immunology