COVID-19, obesity, and immune response 2 years after the pandemic: A timeline of scientific advancesArticle Published on 2022-10-012022-11-16 Journal: Obesity Reviews [Category] COVID19(2023년), SARS, 변종, [키워드] Adiposity body mass index C-reactive protein COVID-19 COVID-19 pandemic described explain expressed immune immune dysregulation immune response individual Inflammatory inflammatory markers inquiry mechanism obesity pathophysiology patients patients with obesity pharmacological treatments poor prognosis progressed researcher SARS-CoV-2 Science scientific advances. the disease vaccination variants [DOI] 10.1111/obr.13496 PMC 바로가기
Therapeutic strategies to fight COVID-19: Which is the status artis?COVID-19와 싸우기 위한 치료 전략: 어떤 상태가 예술입니까?Review Published on 2022-05-012022-09-11 Journal: British Journal of Pharmacology [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Analysis anniversary anti-inflammatory drug Anticoagulants antiviral agent Antiviral agents approach approval article Clinical research clinical trials complex convalescent plasma Corticosteroids COVID COVID-19 Critically ill Critically ill patient disease drug Efficacy and safety European country Evidence Health Organization heparin heparins Hospitalized immunomodulatory investigated patients with COVID-19 pharmacological treatments phase Phase III clinical trials repurposing drugs review robust second wave supported The United States Treatment United States use of corticosteroid Vaccine Vaccines Vitamin D WHO World Health Organization [DOI] 10.1111/bph.15452 PMC 바로가기 [Article Type] Review
Diagnostics and Treatments of COVID-19: A Living Systematic Review of Economic EvaluationsResearch article Published on 2022-05-012022-10-05 Journal: Value in health : the journal of the International [Category] 신약개발, 진단, 치료법, [키워드] Accuracy analyses Analysis approach approaches benefit cost-effectiveness COVID-19 COVID-19 pandemic COVID-19 test database Dexamethasone diagnostic test diagnostics disease severity Economic evaluation effective English estimate estimates evaluated Evidence Gray Health technology assessment Healthcare system Hospitalization hypothetical identify IMPROVE inclusion criteria limitations methodological objective offer pharmacological treatments Remdesivir Repository resolved respond Result review SARS-CoV-2 searched subject survival systematic review Treatment treatments for COVID-19 were excluded [DOI] 10.1016/j.jval.2022.01.001 [Article Type] Research article
Prevalence of COVID-19 Infection among Patients with Diabetes and Their Vaccination Coverage Status in Saudi Arabia: A Cross-Sectional Analysis from a Hospital-Based Diabetes RegistryArticle Published on 2022-02-162022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 95% CI 95% confidence interval accelerate adjusted odds ratio age Analysis city Confirmed COVID-19 infection Coverage COVID-19 COVID-19 infection COVID-19 vaccination determine diabete diabetes dose effective effort Elderly patient Factor female gender female patient groups higher risk hospital Infection infections likelihood male Mortality network pandemic Patient patients with diabete pharmacological treatments platform prevalence of COVID-19 Prince proportion registry representing retrieved Saudi Arabia Severe infection statistically significant difference status subgroup Sultan type 2 diabete vaccination vaccination rate Vaccine hesitancy Vaccines [DOI] 10.3390/vaccines10020310 PMC 바로가기 [Article Type] Article
Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry PerspectiveCOVID-19의 잠재적 치료에 대한 접근: 의약 화학 관점의 일반 개요Review Published on 2022-01-202022-09-10 Journal: Molecules [Category] SARS, 변종, 치료제, [키워드] 3CLpro inhibitors active against affected Anti-inflammatory antibody Antiviral arising Cell characteristic charge Chemistry corticoids Corticosteroids COVID-19 pandemic cytokine Cytokine storm drug drugs targeting elongation factor Genome host cell host protein host proteins hyperinflammatory phase IL6 antibodies Inflammatory interleukin interleukin 6 involved Jak JAK-STAT inhibitors kinases less Mutation pharmacological treatment pharmacological treatments polyprotein Potential protease Protein RdRp inhibitors S antibodies SARS-CoV-2 SARS-CoV2 serine protease inhibitors sphingosine SphK2 inhibitors stages target the cell the disease therapeutic intervention triggered vaccination variants Viral viral entry viral genome viral infection Viral proteins virus [DOI] 10.3390/molecules27030658 PMC 바로가기 [Article Type] Review
Flavonoids as Promising Antiviral Agents against SARS-CoV-2 Infection: A Mechanistic ReviewSARS-CoV-2 감염에 대한 유망한 항바이러스제로서의 플라보노이드: 기계론적 검토Review Published on 2021-06-252022-09-10 Journal: Molecules [Category] SARS, 치료제, [키워드] activity acute respiratory syndrome affected agent Antiviral antiviral activity antiviral properties antiviral property baicalin benefit biological activities clinical manifestation clinical manifestations complications Compound coronavirus COVID-19 COVID-19 disease COVID-19 infection Cytokines derivatives diagnosed disease Ebola Effect effective FIVE flavonoid flavonoids hesperidin HIV host response host responses Human immunodeficiency virus immunodeficiency virus indirect effect indirect effects infective Inflammation inflammatory pathway Influenza inhibit interferons kinases lung MERS Middle East Middle East respiratory syndrome modulate mRNA N-terminal nuclear oxidative damage pharmacological treatments polyphenol pro-inflammatory cytokines protease provide quercetin Regulation respiratory review RNA polymerase RNA virus SARS-CoV-2 Severe acute respiratory syndrome shown Stage subsequent syndrome these compound these compounds Treatment Viral viral infection virus virus replication viruses [DOI] 10.3390/molecules26133900 PMC 바로가기 [Article Type] Review
Ultramicronized Palmitoylethanolamide (um-PEA): A New Possible Adjuvant Treatment in COVID-19 patientsReview Published on 2021-04-062022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] acute respiratory distress adjuvant adjuvant therapy adjuvant treatment Affect Anti-inflammatory ARDS caused characterized clinical picture clinical trial Combination compounds Coronavirus infection COVID-19 COVID-19 patient deaths drug Effect Effects FDA food highlight Hypothesis immunomodulatory in vitro in vivo Infection International Neuroinflammation New organ damage other organ palmitoylethanolamide pandemic pharmacological treatments pulmonary involvement respiratory SARS-CoV-2 SARS-COV-2 infection severe cases Support supported syndrome therapy Treatment ultramicronized palmitoylethanolamide [DOI] 10.3390/ph14040336 PMC 바로가기 [Article Type] Review
SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, ItalySARS-COV-2 동반이환 네트워크 및 이탈리아 크레마 입원 환자의 결과Research Article Published on 2021-03-252022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] Accuracy ACE ACE inhibitor ACE inhibitors Admission angiotensin angiotensin converting enzyme antagonist C-reactive protein caused Chain Reaction Charlson Comorbidity Index Chest CT chest X-ray Comorbidities Comorbidity Computed tomography correlated correlation Course death Deceased diagnostic Diagnostic accuracy disease distribution drug enzyme Fatality rate Follow-up gold gold standard high mortality homogenous hospital hospitalized patient ICU admission impairment individual inhibitor interstitial pneumonia Italy Laboratory males median age Multiorgan Nasopharyngeal swab negative patients network analysis Non-invasive respiratory support occurred outcome outcomes Patient patients patients older pharmacological treatments polymerase chain reaction positive respiratory Respiratory Support reverse transcriptase SARS-CoV-2 significantly study population survived Swab was performed were recorded [DOI] 10.1371/journal.pone.0248498 PMC 바로가기 [Article Type] Research Article
In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19COVID-19에 대한 멕시코 약초에서 분리된 천연 제품의 실리코 스크리닝Communication Published on 2021-02-042022-08-31 Journal: Biomolecules [Category] MERS, 신약개발, [키워드] (quercetin ADME aesculin Analysis Antiviral compounds appear aucubin chemoinformatics cichoriin Compound coumarin COVID-19 COVID-19 pandemic criteria develop distribution docking docking analysis Drug development emodin Herbal identify in silico Isolated kaempferol life lung Luteolin matricin Medicine metabolism natural natural products novel molecule novel molecules pharmacokinetic pharmacological treatments plants product Protein quercetin Research Safe SARS-CoV-2 SARS-CoV-2 virus Screening tartaric acid the SARS-CoV-2 virus therapeutic Treatment Vaccine [DOI] 10.3390/biom11020216 PMC 바로가기 [Article Type] Communication
Review of Trials Currently Testing Stem Cells for Treatment of Respiratory Diseases: Facts Known to Date and Possible Applications to COVID-19호흡기 질환 치료를 위해 현재 줄기 세포를 테스트하는 시험 검토: 현재까지 알려진 사실 및 COVID-19에 대한 가능한 적용Review Published on 2021-02-012022-09-11 Journal: Stem cell reviews and reports [Category] 임상, [키워드] acute respiratory distress syndrome acute respiratory syndrome application ARDS Bone marrow carried clinical clinical study clinical trial clinical trials Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cultured cell cultured cells cytokine Cytokine storm Date Fact feasibility health emergency Health Organization help immunomodulatory Inflammation inhibit International MERS Mesenchymal stem cells Microvesicles Middle East Middle East respiratory syndrome mitigate MSC MSCs outcome pharmacological treatment pharmacological treatments Phase 1 Phase 2 preclinical studies preclinical study Prevent public health emergency respiratory respiratory distress Respiratory distress syndrome review Severe acute respiratory syndrome STEM stem cell stem cells Testing the cytokine storm the disease therapeutic therapy Tolerability Treatment umbilical Umbilical cord WHO World Health Organization [DOI] 10.1007/s12015-020-10033-6 PMC 바로가기 [Article Type] Review